Optical coherence tomography findings in multiple sclerosis and comparison with Primary Sjögren’s syndrome

Optical coherence tomography findings in multiple sclerosis and comparison with Primary Sjögren’s syndrome | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Optical coherence tomography findings in multiple sclerosis and comparison with Primary Sjögren’s syndrome Meral Seferoğlu, Koray Ayar, Neslihan Parmak Yener This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8139231/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Primary Sjögren’s syndrome (PSS) with central nervous system (CNS) involvement can mimic multiple sclerosis (MS). Optical coherence tomography (OCT) quantifies retinal neuroaxonal damage and may assist differential diagnosis. Methods In this case–control study, 170 eyes (60 from participants with MS, 56 from PSS, and 54 from healthy controls [HCs]) were examined with OCT. Peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and foveal, parafoveal and perifoveal retinal thicknesses and foveal volume were measured. Group comparisons, including subgroup analyses of MS with and without previous optic neuritis (ON) and PSS with CNS involvement, used parametric or non-parametric tests (significance p < 0.05). Results Whole RNFL and GCC thickness were significantly lower in MS than in PSS and HCs, with RNFL thinning in all quadrants except nasal. MS showed lower parafoveal and perifoveal retinal thickness and reduced foveal volume compared to PSS and HCs. When MS was compared with PSS with CNS involvement, parafoveal thickness remained significantly lower in MS, whereas other OCT parameters were similar. In three-group analyses, MS with prior ON showed the most pronounced parafoveal and perifoveal thinning versus MS without ON and PSS with CNS involvement, while MS without ON did not differ from PSS with CNS involvement. Conclusions OCT demonstrates more extensive retinal neuroaxonal damage in MS than in PSS and HCs, especially in peripapillary RNFL and parafoveal/perifoveal macula. These findings support the potential role of OCT in differentiating MS from PSS with CNS involvement and in identifying MS patients with more severe neuroaxonal injury. Neurology multiple sclerosis primary Sjögren’s syndrome optical coherence tomography retinal nerve fiber layer optic neuritis Figures Figure 1 INTRODUCTION Multiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system characterized by demyelination, axonal loss, and neurodegeneration. The disease course is heterogeneous, and both clinical attacks and subclinical activity contribute to irreversible disability. Optic neuritis (ON) is one of the most frequent manifestations of MS, and visual pathway involvement is considered a model to study neurodegeneration in this disease ( 1 – 4 ). Optical coherence tomography (OCT) studies have shown that retinal neuroaxonal loss can be detected even in eyes without a history of ON in most patients ( 5 ). Magnetic resonance imaging (MRI) is widely used in the diagnosis and follow-up of MS and is an integral part of the current diagnostic criteria. However, MRI findings can be nonspecific and may be difficult to interpret in patients with comorbidities or in conditions that mimic MS, such as autoimmune connective tissue diseases with central nervous system (CNS) involvement. In such situations, MRI alone may be insufficient for accurate differential diagnosis, which underlines the need for additional, easily applicable biomarkers to support clinical decision making. Optical coherence tomography (OCT) is a non-invasive imaging method that provides high-resolution cross-sectional images of the retina and peripapillary retinal nerve fiber layer (RNFL). Because the retina is an anatomically accessible part of the CNS, OCT has emerged as a useful tool to quantify neuroaxonal damage in MS and other inflammatory or degenerative disorders ( 6 ). In addition, primary Sjögren’s syndrome (PSS) may also present with CNS involvement and MS-like symptoms, which can lead to diagnostic uncertainty. In this context, retinal structural measurements obtained by OCT may potentially contribute to differentiating MS from PSS and from healthy individuals. Therefore, in the present study we evaluated peripapillary RNFL and macular thickness parameters in patients with MS, patients with PSS, and healthy controls to investigate the potential role of OCT in the differential diagnosis of MS. METHODS Study design and participants The present study was designed as a case-control study. A total of 170 eyes were evaluated, 60 from MS participants, 56 from PSS participants, and 54 from healthy controls (HCs), by evaluating both eyes of each participant in the study. MS patients followed up in the Neurology Multiple Sclerosis unit and met the revised criteria of McDonald 2017 ( 7 ). PSS patients were those who were under rheumatology outpatient follow-up and met the 2016 ACR/EULAR criteria ( 8 ). Healthy controls (HCs) were hospital staff. Approval was obtained from the local ethics committee (2011-KAEK-25 2018/07–30) and written consent was obtained from all participants. The procedures of the study were designed and implemented in accordance with the Helsinki Declaration. Inclusion and exclusion criteria Volunteers over the age of 18 and under the age of 65 were included. Participants with pregnancy or cancer were excluded. All MS participants included in the study have relapsing-remitting form and MS patients who had flare in last 3 months were not included in the study. Those with a history of ocular trauma or surgery, media opacity due to cataract or corneal disorder, and those with uveitis, diabetic retinopathy or macular degeneration were excluded from the study. In addition, those with cylindrical refractor error greater than 2.00 diopters, spherical refractor error greater than 4.00 diopters, intraocular blood pressure greater than 21 mmHg and those with poor signal quality (signal strength < 60) were excluded from the study. Study procedures Initial evaluation Demographic data of all participants were recorded. Disease onset age, symptoms, medications, autoantibody tests (anti-nuclear antibody (ANA), anti-Sjögren’s syndrome A (SSA), anti-Sjögren’s syndrome B (SSB), rheumatoid factor) and pathology results of participants were obtained from the records. Cranial magnetic resonance images (MRI) taken previously of PSS and MS participants were evaluated by accessing the records in the PACS system. Neurological examinations of all participants were performed, and cranial MR images of PSS participants and MR images of MS participants were evaluated by a multiple sclerosis specialist neurologist (MS). PSS participants with focal/multifocal or diffuse hyperintense lesions in paraventricular or subcortical white matter on T2 sequences on brain MRI were considered PSS participants with CNS involvement. Ophthalmological examinations were performed by a specialist neuro-ophthalmologist (NPY). Patients with MS who were previously diagnosed with ON according to neuro-ophthalmologic examination and electrophysiologic findings and whose current anamnesis and ophthalmologic assessment were compatible with a previous ON attack were included in the subgroup of MS participants with ON. The level of disability of MS participants was evaluated with the Expanded Disability Status Scale (EDSS) ( 9 ). Optical coherence tomography Fourier-Domain Optical Coherence Tomography (OCT) device (RTVue-XR Avanti; Optovue Inc, Fremont, CA), an ultrahigh resolution OCT device, was used for measurements. This system operates with a wavelength of 840 nm and has an axial scanning speed of 70,000 per second and a resolution of 5 µm. OCT measurements were made by a single ophthalmologist (NPY) in both eyes after pupil dilation was provided with 1% tropicamide, and measurements with a signal strength indicator (SSI) of 60 and above were considered reliable and used for analysis. OCT measurements were made with 3 protocols: peripapillary, ganglion cell complex (GCC) and macula protocols. In the peripapillary protocol, the thickness of retinal nerve fiber layer (RNFL) was measured in a 3.45 mm diameter circular section with the optic disc in the center as a standard protocol. The thickness of the RNFL was measured in the whole area and in the superior, inferior, nasal and temporal regions. In the GCC protocol, GCC thickness in the macula was measured in the whole area and in the superior and inferior regions. In the macula protocol, retinal thickness was measured in the areas of the fovea, parafovea and perifovea, which are the regions defined by the Early Treatment of Diabetic Retinopathy Study. Retinal thickness was measured in the superior, inferior, nasal and temporal regions of the parafovea and perifovea areas. In the fovea area, retinal thickness and volume was measured only in the whole area. Statistical analysis Statistical analyzes were performed using SPSS version 21.0 (SPSS Inc., Chicago, IL, USA). The normality of all data was evaluated using the Kolmogorov Smirnov or Shapiro-Wilk test. T-test was used to compare the quantitative data with normal distribution between 2 groups, and Mann-Whitney U test was used in cases where there was no normal distribution. In the comparison of quantitative data between 3 groups, ANOVA test was used when there was normal distribution, and Kruskal-Wallis test was used when there was no normal distribution. Tukey test was used in post hoc analysis. Chi-square (χ 2 ) test was used to compare qualitative data. As statistical significance p < 0.05 was accepted. RESULTS Characteristics of the participants Demographic data, clinical and laboratory characteristics of MS participants, and the drugs they use is shown in Table-1. The mean age of MS participants was 42.5 ± 6.4 years, and most of them were female (86.7%). Demographic data and clinical, laboratory and salivary gland pathological results of PSS participants, and the drugs they use is shown in Table-2. The mean age of PSS participants was 47.2 ± 6.6 years, and all of them were female. Minor salivary gland biopsy results of 21 PSS patients were evaluable, and grade 3–4 sialadenitis was detected in 17 of them. The mean age of HCs was 46.5 ± 10.5 years, and 24 of them were female (88.9%). Gender distributions of MS participants were not different from PSS participants and HCs (p = 0.113, p = 0.799, respectively). However, the mean age of MS participants was different from PSS participants (p = 0.008), but not from HCs (p = 0.096). Optical coherence tomography parameters Comparison of MS participants with PSS participants and healthy individuals Comparison of OCT measurements of MS participants with PSS participants and HCs is shown in Table-3 and with a summary in Fig. 1 . Whole RNFL thickness was 88.8 ± 12.5, 101.3 ± 10.0 and 98.1 ± 8.8 µm in MS participants, PSS participants and HCs, respectively, and was significantly lower in MS participants than in PSS participants and HCs (p < 0.001, p < 0.001, respectively). RNFL thickness was found to be significantly lower in MS participants than in PSS participants and HCs in all RNFL regions (superior, inferior, temporal) except the nasal region. Whole GCC thickness was 85.8 ± 14.4, 95.7 ± 6.9 and 95.6 ± 7.1 µm in MS participants, PSS participants and HCs, respectively, and was significantly lower in MS participants than in PSS participants and HCs (p < 0.001, p < 0.001, respectively). Foveal thickness was 244.7 ± 19.1, 249.7 ± 22.2 and 256.2 ± 18.6 µm in MS participants, PSS participants and HCs, respectively, and was not different from PSS participants in MS participants (p = 0.378) but was lower than in HCs (p = 0.002). Retinal thickness in the parafoveal area was significantly lower in MS participants than in PSS participants and HCs in all regions (inferior, superior, nasal, temporal). Retinal thickness in the perifoveal area was significantly lower in MS participants in the inferior, superior and nasal regions than in PSS participants and HCs. However, although retinal thickness in the temporal region of the perifoveal area was significantly lower in MS participants than in PSS participants (p = 0.008), it was not different from that in HCs (p = 0.067). Foveal volume was 6.95 ± 0.51, 7.33 ± 0.75, and 7.19 ± 0.34 mm³ in MS participants, PSS participants, and HCs, respectively, and was lower in MS participants than in PSS participants and HCs (p = 0.001, p = 0.003, respectively). Figure 1 : Schematic representation of RNFL and macular thickness in HC, PSS and MS Comparison of MS participants and PSS participants with CNS involvement Comparison of OCT measurements of MS participants and PSS participants with CNS involvement is shown in Table-4. Whole RNFL thickness was 88.8 ± 12.5 and 93.1 ± 11.9 µm in MS participants and PSS participants with CNS involvement, respectively. Whole GCC thickness was 85.8 ± 14.4 and 90.9 ± 6.2 µm in MS participants and PSS participants with CNS involvement, respectively. Foveal thickness was 244.7 ± 19.1 and 255.4 ± 35.9 µm in MS participants and PSS participants with CNS involvement, respectively. Retinal thickness in the RNFL, GCC, fovea and perifovea areas was not different in MS participants than in PSS participants with CNS involvement in any region. However, retinal thickness in the superior, inferior, and temporal regions of the parafovea area was significantly lower in MS participants than in PSS participants with CNS involvement (p = 0.031, p = 0.017, and p = 0.012, respectively). Foveal volume was 6.95 ± 0.51 and 7.27 ± 0.63 mm³ in MS participants and PSS participants with CNS involvement, respectively, and the difference was not significant (p = 0.097). Comparison of OCT measurements between MS participants with and without ON and participants with PSS with CNS involvement is shown in Table-5. RNFL and GCC thickness was not different between PSS participants with CNS involvement and MS participants with or without ON in any region. Retinal thickness in parafovea and perifovea areas was different between 3 groups in all regions. In post hoc analysis, retinal thickness was found to be lower in the nasal and temporal regions of both parafovea (p = 0.024 and p = 0.040, respectively) and perifovea (p = 0.018 and p = 0.016, respectively) areas in MS patients with ON than in MS patients without ON. Compared with PSS participants with CNS involvement, MS participants with ON exhibited significantly reduced retinal thickness in the superior (p = 0.026), inferior (p = 0.017), and nasal (p = 0.039) parafoveal regions, as well as in the inferior (p = 0.019), nasal (p = 0.001), and temporal (p = 0.001) perifoveal regions. In the comparison between MS participants without ON and PSS participants with CNS involvement, retinal thickness was not different in any region of any area. While retinal thickness in the foveal area was not different between groups, foveal volume was found to be lower in MS participants with ON than in PSS participants with CNS involvement (p = 0.017). DISCUSSION In clinical practice, several disorders with CNS involvement can mimic MS both clinically and radiologically. Among them, autoimmune connective tissue diseases such as primary Sjögren’s syndrome may present with white matter lesions, episodes suggestive of demyelination, or even optic neuritis, which can lead to misdiagnosis. In such scenarios, additional biomarkers that reflect neuroaxonal damage and can be obtained in a quick and non-invasive manner are highly desirable. OCT has been proposed as one such tool, because it allows direct visualization and quantification of retinal layers that correspond to unmyelinated axons and neurons of the CNS. On this basis, we aimed to investigate whether OCT parameters could help distinguish MS from PSS and from healthy individuals. Our study showed RNFL thickness was found to be significantly lower in MS participants than in PSS participants and HCs in all RNFL regions (superior, inferior, temporal) except the nasal region. Whole GCC thickness was significantly lower in MS participants than in PSS participants and HC. Foveal volume was lower in MS participants than in PSS participants and HCs. When MS patients were compared with PSS with CNS involvement; retinal thickness were found to be lower only in the parafoveal region in MS patients. Also foveal volume was found to be lower in MS participants with ON than in PSS participants with CNS involvement (p = 0.017). OCT findings were similar when MS patients without ON and PSS patients with CNS lesions were compared. In MS patients with ON, retinal thicknesses were found to be lower in the parafoveal and perifoveal area in MS patients compared to PSS patients with CNS lesions. When the retinal thicknesses of all MS patients and PSS patients with CNS lesions were compared, retinal thickness was found to be lower in the parafoveal region in MS patients. It can be interpreted that the parafoveal region is prominent in the differential diagnosis of MS patients from PSS patients with CNS involvement. Parafoveal region seems to be important in differential diagnosis of MS. Our findings are in line with previous work that evaluated OCT for the differential diagnosis of MS and autoimmune connective tissue diseases with CNS involvement. In the study by Wildner et al., OCT measurements were compared among MS patients, patients with CNS involvement in connective tissue diseases, and healthy controls, and significant group effects were demonstrated for peripapillary RNFL and macular parameters, supporting the concept that retinal structural changes may reflect disease-specific patterns of CNS injury [10]. Similar to that study, we observed that MS patients showed more pronounced RNFL thinning than PSS participants and healthy controls, particularly in the superior, inferior, and temporal quadrants, whereas the nasal quadrant was relatively preserved. OCT has substantially improved our understanding of the pathophysiological mechanisms in MS. Several studies have shown that thinning of the RNFL and ganglion cell–inner plexiform layer (GCIPL) occurs not only after ON but also in eyes without a history of optic nerve inflammation, indicating that retinal neuroaxonal loss is a diffuse manifestation of CNS pathology rather than a purely local phenomenon. These structural changes correlate with visual dysfunction and, in many reports, with global measures of disability, supporting the use of OCT as a biomarker of neurodegeneration in MS ( 11 ). The observation of RNFL and macular thinning in our MS cohort, including eyes without ON, is consistent with this concept. Recent revisions of the McDonald diagnostic criteria (2024) have now formally incorporated the visual system into the diagnostic framework ( 12 ). The optic nerve is recognized as a fifth topographic site for dissemination in space, and abnormal findings on orbital MRI, visual evoked potentials or OCT can all provide paraclinical evidence of optic nerve involvement when no better explanation exists. Within these revisions, OCT-derived inter-eye differences in peripapillary RNFL and macular ganglion cell–inner plexiform layer thickness are specifically recommended as supportive measures to document unilateral optic nerve damage. In this updated context, our results suggest that quantitative retinal structural measurements obtained by OCT not only reflect neuroaxonal damage in MS but may also help to document optic nerve involvement and to distinguish MS from PSS with CNS involvement in diagnostically challenging cases, especially when conventional MRI findings are equivocal ( 12 , 13 ). Beyond structural OCT, optical coherence tomography angiography (OCTA) has emerged as a promising technique to assess retinal microvasculature in systemic autoimmune diseases. Several studies have reported reduced vessel density in the superficial and deep capillary plexus in MS and in PSS, even in the absence of overt ocular disease. Recently, Wolf et al. used OCTA to directly compare patients with relapsing–remitting MS and patients with PSS and demonstrated distinct patterns of retinal vascular alteration in the two diseases, suggesting that MS and PSS are associated with different retinal pathologies at the microvascular level ( 10 , 11 ). Although our study did not include OCTA measurements, the structural thinning of RNFL and macular layers that we observed in MS compared with PSS and healthy controls may represent the neuroaxonal counterpart of these microvascular abnormalities. This study has some limitations that should be acknowledged. The study population was of moderate size and the subgroup of PSS patients with CNS involvement was relatively small, which may have limited our ability to detect more subtle differences in OCT parameters between the groups. In addition, the single-center, cross-sectional design does not capture longitudinal change and may restrict the generalizability of the results. We also focused exclusively on structural OCT measures and did not include OCT angiography, so possible microvascular alterations could not be directly evaluated in this cohort. Finally, although key demographic and clinical factors were considered, the influence of unmeasured confounders cannot be completely excluded. These considerations may help to guide future research, including larger multicenter cohorts and longitudinal studies that combine structural OCT with OCT angiography to further clarify the diagnostic and prognostic value of retinal imaging in MS and PSS. Our findings, in concordance with previous reports, indicate that OCT-derived retinal biomarkers may assist in differentiating MS, PSS with CNS involvement, and healthy individuals. Structural OCT yields quantitative measures of neuroaxonal damage, whereas OCTA provides complementary information on retinal microvascular alterations. Future studies that integrate both modalities in larger cohorts with longitudinal follow-up are warranted to clarify the interplay between structural and vascular retinal changes and to determine whether their combined use can enhance the early and accurate diagnosis of MS in patients with overlapping clinical or radiological features. Declarations On behalf of all authors, the corresponding author states that there is no conflict of interest. References Balcer LJ (2006) Clinical practice. Optic neuritis. N Engl J Med 354(12):1273–1280 Arnold AC (2005) Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 139(6):1101–1108 Foroozan R, Buono LM, Savino PJ, Sergott RC (2002) Acute demyelinating optic neuritis. Curr Opin Ophthalmol 13(6):375–380 Frohman EM, Frohman TC, Zee DS, McColl R, Galetta S (2005) The neuro-ophthalmology of multiple sclerosis. Lancet Neurol 4(2):111–121 Britze J, Frederiksen JL (2018) Optical coherence tomography in multiple sclerosis. 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PMID: 40975103 Tables Table-1: Demographic data, clinical and laboratory characteristics of MS participants, and the drugs they use. mean ± SD Median min-max Age at disease onset 31.7 ± 7.5 31.5 18.0–48.0 Age 42.5 ± 6.4 41.5 33.0–64.0 Disease duration, years 10.8 ± 5.7 10.0 1.0–22.0 Flairs/year 0.5 ± 0.9 0.0 0.0–3.0 Treatment duration, years 9.0 ± 6.0 9.5 0.0–20.0 EDSS 2.3 ± 1.5 2.0 0.0-5.5 Frequencies, n (%) Female 26 (86.7) Clinic at disease onset mono-symptomatic 8 (26.7) poly-symptomatic 22 (73.3) Optic neuritis not present 11 (36.7) right 3 (10.0) left 5 (16.7) bilateral 11 (36.7) Drugs interferon-β 9 (30.0) fingolimod 8 (26.7) glatiramer acetate 5 (16.7) teriflunomide 3 (10.0) rituximab 1 (3.3) no medication 4 (13.3) MS: Multiple sclerosis, SD: standard deviation, min: minimum, max: maximum, EDSS: Expanded Disability Status Scale. Table-2: Demographic data and clinical, laboratory and salivary gland pathological results of PSS participants, and the drugs they use. mean ± SD median min-max Age at disease onset, years 40.5 ± 9.7 40.5 17.0–55.0 Age, years 47.2 ± 6.6 45.5 33.0–58.0 Disease duration, years 6.7 ± 5.5 5.0 2.0–23.0 Female, n (%) 28 (100) Sicca symptoms, n (%) oral 22 (78.6) ocular 24 (85.7) Raynaud, n (%) 7 (25.0) CNS involvement, n (%) 7 (25.0) Minor salivary gland biopsy ‡ , n = 21 grade 0 2 grade 1 1 grade 2 1 grade 3 5 grade 4 12 Antibodies, positive, n (%) ANA 27 (96.4) Anti-SSA 22 (78.6) Anti-SSB 10 (35.7) RF 12 (42.9) Drugs, n (%) hydroxychloroquine 26 (92.9) pilocarpine 2 (7.1) methotrexate 3 (10.7) corticosteroids 16 (57.1) azathioprine 5 (17.9) pregabalin 7 (25.0) duloxetine 4 (14.3) PSS: Primary Sjögren's syndrome, SD: standard deviation, CNS: central nerves system, ‡ according to Chisholm score, ANA: antinuclear antibody, SSA: Sjögren’s syndrome A, SSB: Sjögren’s syndrome B, RF: Rheumatoid factor. Table-3: Comparison of OCT measurements of MS participants patients with PSS participants and HCs. MS (n = 60) PSS (n = 56) HCs (n = 54) p1 p2 Thickness, mean ± SD RNFL, µm 88.8 ± 12.5 101.3 ± 10.0 98.1 ± 8.8 0.000 0.000 inferior 100.5 ± 19.0 116.2 ± 19.6 118.4 ± 11.1 0.000 0.000 superior 101.9 ± 17.7 116.6 ± 18.1 118.6 ± 14.2 0.000 0.000 nasal 76.6 ± 20.4 79.2 ± 10.5 81.0 ± 17.4 0.400 0.238 temporal 63.7 ± 14.6 76.1 ± 11.3 74.8 ± 10.2 0.000 0.000 GCC, µm 85.8 ± 14.4 95.7 ± 6.9 95.6 ± 7.1 0.000 0.000 superior 85.1 ± 13.5 95.4 ± 7.3 95.2 ± 7.6 0.000 0.000 inferior 86.5 ± 15.7 95.9 ± 7.0 96.4 ± 6.8 0.000 0.000 Fovea, µm 244.7 ± 19.1 249.7 ± 22.2 256.2 ± 18.6 0.378 0.002 Parafovea, µm inferior 305.3 ± 39.0 320.7 ± 45.6 314.6 ± 16.2 0.001 0.000 superior 300.1 ± 37.5 323.2 ± 45.3 317.1 ± 16.2 0.000 0.000 nasal 299.2 ± 23.1 320.9 ± 46.3 315.2 ± 16.5 0.000 0.000 temporal 291.2 ± 23.5 311.8 ± 41.3 305.7 ± 16.6 0.000 0.001 Perifovea, µm inferior 270.5 ± 21.9 284.8 ± 32.6 277.4 ± 14.9 0.003 0.021 superior 278.4 ± 19.4 293.3 ± 26.9 286.9 ± 14.3 0.001 0.009 nasal 287.1 ± 26.2 303.2 ± 34.3 300.5 ± 16.3 0.000 0.000 temporal 271.0 ± 25.8 281.6 ± 25.3 275.5 ± 15.3 0.008 0.067 FV, mm³, mean ± SD 6.95 ± 0.51 7.33 ± 0.75 7.19 ± 0.34 0.001 0.003 OCT: optical coherence tomography, MS: multiple sclerosis, PSS: Primary Sjögren's syndrome, HCs: healthy controls, SD: standard deviation, RNFL: retinal nerve fiber layer, GCC: ganglion cell complex, FV: fovea volume. p1: MS vs SS p2: MS vs controls Table-4: Comparison of OCT measurements of MS participants and PSS participants with CNS involvement. MS (n = 60) PSS with CNSL (n = 14) p Thickness, mean ± SD RNFL, µm 88.8 ± 12.5 93.1 ± 11.9 0.265 inferior 100.5 ± 19.0 105.9 ± 22.9 0.233 superior 101.9 ± 17.7 109.1 ± 18.1 0.155 nasal 76.6 ± 20.4 72.1 ± 9.2 0.628 temporal 63.7 ± 14.6 70.3 ± 9.5 0.106 GCC, µm 85.8 ± 14.4 90.9 ± 6.2 0.106 superior 85.1 ± 13.5 89.7 ± 5.6 0.165 inferior 86.5 ± 15.7 92.0 ± 7.0 0.077 Fovea, µm 244.7 ± 19.1 255.4 ± 35.9 0.537 Parafovea, µm inferior 305.3 ± 39.0 318.9 ± 41.6 0.077 superior 300.1 ± 37.5 322.9 ± 40.6 0.031 * nasal 299.2 ± 23.1 318.2 ± 25.7 0.017 * temporal 291.2 ± 23.5 311.6 ± 22.9 0.012 * Perifovea, µm inferior 270.5 ± 21.9 286.5 ± 38.5 0.098 superior 278.4 ± 19.4 297.7 ± 47.1 0.253 nasal 287.1 ± 26.2 298.7 ± 27.9 0.075 temporal 271.0 ± 25.8 278.2 ± 15.7 0.101 FV, mm³, mean ± SD 6.95 ± 0.51 7.27 ± 0.63 0.097 OCT: optical coherence tomography, pr: parameters, MS: multiple sclerosis, PSS: Primary Sjögren's syndrome, CNSL: central nervous system lesion, SD: standard deviation, RNFL: retinal nerve fiber layer, GCC: ganglion cell complex, FV: fovea volume, * p < 0.05. Table-5: Comparison of OCT measurements between MS participants with and without optic neuritis and participants with Primary Sjögren's syndrome with central nervous system lesion. MS PSS with CNSI (n = 14) p1 ‡ p2 ‡ p3 ‡ p4 ON- (n = 30) ON+ (n = 30) Thickness, mean ± SD RNFL, µm 90.7 ± 13.6 86.8 ± 11.1 93.1 ± 11.9 0.239 0.440 0.258 0.818 inferior 102.8 ± 21.9 98.2 ± 15.4 105.9 ± 22.9 0.441 0.639 0.454 0.879 superior 103.6 ± 20.0 100.1 ± 15.2 109.1 ± 18.1 0.304 0.724 0.274 0.616 nasal 80.0 ± 20.0 73.2 ± 20.7 72.1 ± 9.2 0.289 0.360 0.982 0.406 temporal 65.8 ± 16.1 61.6 ± 12.9 70.3 ± 9.5 0.144 0.468 0.133 0.583 GCC, µm 88.4 ± 16.4 83.2 ± 11.7 90.9 ± 6.2 0.144 0.287 0.176 0.827 superior 87.6 ± 14.9 82.6 ± 11.6 89.7 ± 5.6 0.142 0.263 0.185 0.863 inferior 89.1 ± 18.2 83.8 ± 12.3 92.0 ± 7.0 0.165 0.333 0.192 0.811 Fovea, µm 250.3 ± 17.9 238.9 ± 18.7 255.4 ± 35.9 0.051 0.139 0.073 0.768 Parafovea, µm inferior 277.3 ± 23.8 263.4 ± 17.6 286.5 ± 38.5 0.014 0.093 0.017 0.499 superior 282.0 ± 20.1 274.6 ± 18.2 297.7 ± 47.1 0.034 0.538 0.026 0.172 nasal 295.9 ± 28.5 278.0 ± 20.4 298.7 ± 27.9 0.011 0.024 0.039 0.936 temporal 278.5 ± 25.9 263.3 ± 23.7 278.2 ± 15.7 0.032 0.040 0.132 0.999 Perifovea, µm inferior 317.0 ± 47.4 293.2 ± 22.9 318.9 ± 41.6 0.033 0.051 0.104 0.986 superior 310.5 ± 25.9 289.3 ± 44.5 322.9 ± 40.6 0.014 0.080 0.019 0.561 nasal 307.3 ± 22.8 290.9 ± 20.6 318.2 ± 25.7 0.001 0.018 0.001 0.296 temporal 299.4 ± 19.6 282.8 ± 24.6 311.6 ± 22.9 0.000 0.016 0.001 0.216 FV, mm³, mean ± SD 7.1 ± 0.4 6.8 ± 0.5 7.3 ± 0.6 0.011 0.061 0.017 0.590 OCT: optical coherence tomography, MS: multiple sclerosis, ON: optic neuritis, PSS: Primary Sjögren's syndrome, CNSI: central nervous system involvement ‡ post hoc analysis, SD: standard deviation, RNFL: retinal nerve fiber layer, GCC: ganglion cell complex, FV: foveal volume P1: MS/ON- vs MS/ON + vs PSS p2: MS/ON- vs MS/ON+ P3: MS/ON + vs PSS P4: MS/ON- vs PSS Additional Declarations The authors declare no competing interests. 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Seferoğlu","email":"data:image/png;base64,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","orcid":"https://orcid.org/0000-0003-3858-0306","institution":"Bursa Yüksek İhtisas Training and Research Hospital, Neurology","correspondingAuthor":true,"prefix":"","firstName":"Meral","middleName":"","lastName":"Seferoğlu","suffix":""},{"id":546563294,"identity":"7e5c2003-4d83-4cbc-b3ef-2c7cb0accd28","order_by":1,"name":"Koray Ayar","email":"","orcid":"","institution":"Bursa Yüksek İhtisas Training and Research Hospital, Rheumatology","correspondingAuthor":false,"prefix":"","firstName":"Koray","middleName":"","lastName":"Ayar","suffix":""},{"id":546563295,"identity":"1779976e-dcb7-426e-b6b7-7bfff2abef45","order_by":2,"name":"Neslihan Parmak Yener","email":"","orcid":"","institution":"Bursa Yüksek İhtisas Training and Research Hospital, Opthalmology","correspondingAuthor":false,"prefix":"","firstName":"Neslihan","middleName":"Parmak","lastName":"Yener","suffix":""}],"badges":[],"createdAt":"2025-11-17 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12:14:00","extension":"xml","order_by":5,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":130843,"visible":true,"origin":"","legend":"","description":"","filename":"rs81392310structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-8139231/v1/0623bf65d4c1a362fecaa108.xml"},{"id":96288905,"identity":"accc1285-4916-472f-9bad-ad1c64a821b9","added_by":"auto","created_at":"2025-11-19 12:14:00","extension":"html","order_by":6,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":139563,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-8139231/v1/dd7bee7f51f55ac2f073eaa8.html"},{"id":96288902,"identity":"121fe2aa-1397-44dc-840e-5645e6190103","added_by":"auto","created_at":"2025-11-19 12:14:00","extension":"jpeg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":259220,"visible":true,"origin":"","legend":"\u003cp\u003eSchematic representation of peripapillary retinal nerve fiber layer (RNFL) and macular thickness in healthy controls (HC), patients with primary Sjögren’s syndrome (PSS), and patients with multiple sclerosis (MS). Upper row: peripapillary RNFL quadrants (temporal [T], superior [S], nasal [N], inferior [I]). Lower row: macular thickness in foveal, parafoveal, and perifoveal regions, with parafoveal and perifoveal rings subdivided into four quadrants. Colors indicate the relative degree of thinning (green: within normal limits; yellow: mild thinning; orange: marked thinning). In line with the quantitative OCT measurements (Table 3), MS shows pronounced thinning in the inferior, superior, and temporal RNFL quadrants with relative nasal sparing, as well as marked parafoveal and perifoveal thinning compared with PSS and healthy controls.\u003c/p\u003e","description":"","filename":"floatimage1.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-8139231/v1/7117fda4c4a860badd032fa0.jpeg"},{"id":96369264,"identity":"65b5d5fd-049a-4368-8aca-3dd84cac0df5","added_by":"auto","created_at":"2025-11-20 10:20:15","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1607875,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8139231/v1/2874612e-43fd-401e-bc67-34b840dffe45.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003e\u003cstrong\u003eOptical coherence tomography findings in multiple sclerosis and comparison with Primary Sjögren’s syndrome\u003c/strong\u003e\u003c/p\u003e","fulltext":[{"header":"INTRODUCTION","content":"\u003cp\u003eMultiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system characterized by demyelination, axonal loss, and neurodegeneration. The disease course is heterogeneous, and both clinical attacks and subclinical activity contribute to irreversible disability. Optic neuritis (ON) is one of the most frequent manifestations of MS, and visual pathway involvement is considered a model to study neurodegeneration in this disease (\u003cspan additionalcitationids=\"CR2 CR3\" citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e). Optical coherence tomography (OCT) studies have shown that retinal neuroaxonal loss can be detected even in eyes without a history of ON in most patients (\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eMagnetic resonance imaging (MRI) is widely used in the diagnosis and follow-up of MS and is an integral part of the current diagnostic criteria. However, MRI findings can be nonspecific and may be difficult to interpret in patients with comorbidities or in conditions that mimic MS, such as autoimmune connective tissue diseases with central nervous system (CNS) involvement. In such situations, MRI alone may be insufficient for accurate differential diagnosis, which underlines the need for additional, easily applicable biomarkers to support clinical decision making.\u003c/p\u003e\u003cp\u003eOptical coherence tomography (OCT) is a non-invasive imaging method that provides high-resolution cross-sectional images of the retina and peripapillary retinal nerve fiber layer (RNFL). Because the retina is an anatomically accessible part of the CNS, OCT has emerged as a useful tool to quantify neuroaxonal damage in MS and other inflammatory or degenerative disorders (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e). In addition, primary Sj\u0026ouml;gren\u0026rsquo;s syndrome (PSS) may also present with CNS involvement and MS-like symptoms, which can lead to diagnostic uncertainty. In this context, retinal structural measurements obtained by OCT may potentially contribute to differentiating MS from PSS and from healthy individuals. Therefore, in the present study we evaluated peripapillary RNFL and macular thickness parameters in patients with MS, patients with PSS, and healthy controls to investigate the potential role of OCT in the differential diagnosis of MS.\u003c/p\u003e"},{"header":"METHODS","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\u003ch2\u003eStudy design and participants\u003c/h2\u003e\u003cp\u003eThe present study was designed as a case-control study. A total of 170 eyes were evaluated, 60 from MS participants, 56 from PSS participants, and 54 from healthy controls (HCs), by evaluating both eyes of each participant in the study. MS patients followed up in the Neurology Multiple Sclerosis unit and met the revised criteria of McDonald 2017 (\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e). PSS patients were those who were under rheumatology outpatient follow-up and met the 2016 ACR/EULAR criteria (\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e). Healthy controls (HCs) were hospital staff. Approval was obtained from the local ethics committee (2011-KAEK-25 2018/07\u0026ndash;30) and written consent was obtained from all participants. The procedures of the study were designed and implemented in accordance with the Helsinki Declaration.\u003c/p\u003e\u003c/div\u003e\n\u003ch3\u003eInclusion and exclusion criteria\u003c/h3\u003e\n\u003cp\u003eVolunteers over the age of 18 and under the age of 65 were included. Participants with pregnancy or cancer were excluded. All MS participants included in the study have relapsing-remitting form and MS patients who had flare in last 3 months were not included in the study. Those with a history of ocular trauma or surgery, media opacity due to cataract or corneal disorder, and those with uveitis, diabetic retinopathy or macular degeneration were excluded from the study. In addition, those with cylindrical refractor error greater than 2.00 diopters, spherical refractor error greater than 4.00 diopters, intraocular blood pressure greater than 21 mmHg and those with poor signal quality (signal strength\u0026thinsp;\u0026lt;\u0026thinsp;60) were excluded from the study.\u003c/p\u003e\n\u003ch3\u003eStudy procedures\u003c/h3\u003e\n\u003cdiv id=\"Sec6\" class=\"Section2\"\u003e\u003ch2\u003eInitial evaluation\u003c/h2\u003e\u003cp\u003eDemographic data of all participants were recorded. Disease onset age, symptoms, medications, autoantibody tests (anti-nuclear antibody (ANA), anti-Sj\u0026ouml;gren\u0026rsquo;s syndrome A (SSA), anti-Sj\u0026ouml;gren\u0026rsquo;s syndrome B (SSB), rheumatoid factor) and pathology results of participants were obtained from the records. Cranial magnetic resonance images (MRI) taken previously of PSS and MS participants were evaluated by accessing the records in the PACS system. Neurological examinations of all participants were performed, and cranial MR images of PSS participants and MR images of MS participants were evaluated by a multiple sclerosis specialist neurologist (MS). PSS participants with focal/multifocal or diffuse hyperintense lesions in paraventricular or subcortical white matter on T2 sequences on brain MRI were considered PSS participants with CNS involvement. Ophthalmological examinations were performed by a specialist neuro-ophthalmologist (NPY). Patients with MS who were previously diagnosed with ON according to neuro-ophthalmologic examination and electrophysiologic findings and whose current anamnesis and ophthalmologic assessment were compatible with a previous ON attack were included in the subgroup of MS participants with ON. The level of disability of MS participants was evaluated with the Expanded Disability Status Scale (EDSS) (\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e).\u003c/p\u003e\u003c/div\u003e\n\u003ch3\u003eOptical coherence tomography\u003c/h3\u003e\n\u003cp\u003eFourier-Domain Optical Coherence Tomography (OCT) device (RTVue-XR Avanti; Optovue Inc, Fremont, CA), an ultrahigh resolution OCT device, was used for measurements. This system operates with a wavelength of 840 nm and has an axial scanning speed of 70,000 per second and a resolution of 5 \u0026micro;m. OCT measurements were made by a single ophthalmologist (NPY) in both eyes after pupil dilation was provided with 1% tropicamide, and measurements with a signal strength indicator (SSI) of 60 and above were considered reliable and used for analysis. OCT measurements were made with 3 protocols: peripapillary, ganglion cell complex (GCC) and macula protocols. In the peripapillary protocol, the thickness of retinal nerve fiber layer (RNFL) was measured in a 3.45 mm diameter circular section with the optic disc in the center as a standard protocol. The thickness of the RNFL was measured in the whole area and in the superior, inferior, nasal and temporal regions. In the GCC protocol, GCC thickness in the macula was measured in the whole area and in the superior and inferior regions. In the macula protocol, retinal thickness was measured in the areas of the fovea, parafovea and perifovea, which are the regions defined by the Early Treatment of Diabetic Retinopathy Study. Retinal thickness was measured in the superior, inferior, nasal and temporal regions of the parafovea and perifovea areas. In the fovea area, retinal thickness and volume was measured only in the whole area.\u003c/p\u003e\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e\u003ch2\u003eStatistical analysis\u003c/h2\u003e\u003cp\u003eStatistical analyzes were performed using SPSS version 21.0 (SPSS Inc., Chicago, IL, USA). The normality of all data was evaluated using the Kolmogorov Smirnov or Shapiro-Wilk test. T-test was used to compare the quantitative data with normal distribution between 2 groups, and Mann-Whitney U test was used in cases where there was no normal distribution. In the comparison of quantitative data between 3 groups, ANOVA test was used when there was normal distribution, and Kruskal-Wallis test was used when there was no normal distribution. Tukey test was used in post hoc analysis. Chi-square (χ\u003csup\u003e2\u003c/sup\u003e) test was used to compare qualitative data. As statistical significance p\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was accepted.\u003c/p\u003e\u003c/div\u003e"},{"header":"RESULTS","content":"\u003cdiv id=\"Sec10\" class=\"Section2\"\u003e\u003ch2\u003eCharacteristics of the participants\u003c/h2\u003e\u003cp\u003eDemographic data, clinical and laboratory characteristics of MS participants, and the drugs they use is shown in Table-1. The mean age of MS participants was 42.5\u0026thinsp;\u0026plusmn;\u0026thinsp;6.4 years, and most of them were female (86.7%). Demographic data and clinical, laboratory and salivary gland pathological results of PSS participants, and the drugs they use is shown in Table-2. The mean age of PSS participants was 47.2\u0026thinsp;\u0026plusmn;\u0026thinsp;6.6 years, and all of them were female. Minor salivary gland biopsy results of 21 PSS patients were evaluable, and grade 3\u0026ndash;4 sialadenitis was detected in 17 of them. The mean age of HCs was 46.5\u0026thinsp;\u0026plusmn;\u0026thinsp;10.5 years, and 24 of them were female (88.9%). Gender distributions of MS participants were not different from PSS participants and HCs (p\u0026thinsp;=\u0026thinsp;0.113, p\u0026thinsp;=\u0026thinsp;0.799, respectively). However, the mean age of MS participants was different from PSS participants (p\u0026thinsp;=\u0026thinsp;0.008), but not from HCs (p\u0026thinsp;=\u0026thinsp;0.096).\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e\u003ch2\u003eOptical coherence tomography parameters\u003c/h2\u003e\u003cdiv id=\"Sec12\" class=\"Section3\"\u003e\u003ch2\u003eComparison of MS participants with PSS participants and healthy individuals\u003c/h2\u003e\u003cp\u003eComparison of OCT measurements of MS participants with PSS participants and HCs is shown in Table-3 and with a summary in Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e1\u003c/span\u003e. Whole RNFL thickness was 88.8\u0026thinsp;\u0026plusmn;\u0026thinsp;12.5, 101.3\u0026thinsp;\u0026plusmn;\u0026thinsp;10.0 and 98.1\u0026thinsp;\u0026plusmn;\u0026thinsp;8.8 \u0026micro;m in MS participants, PSS participants and HCs, respectively, and was significantly lower in MS participants than in PSS participants and HCs (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001, respectively). RNFL thickness was found to be significantly lower in MS participants than in PSS participants and HCs in all RNFL regions (superior, inferior, temporal) except the nasal region. Whole GCC thickness was 85.8\u0026thinsp;\u0026plusmn;\u0026thinsp;14.4, 95.7\u0026thinsp;\u0026plusmn;\u0026thinsp;6.9 and 95.6\u0026thinsp;\u0026plusmn;\u0026thinsp;7.1 \u0026micro;m in MS participants, PSS participants and HCs, respectively, and was significantly lower in MS participants than in PSS participants and HCs (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001, respectively). Foveal thickness was 244.7\u0026thinsp;\u0026plusmn;\u0026thinsp;19.1, 249.7\u0026thinsp;\u0026plusmn;\u0026thinsp;22.2 and 256.2\u0026thinsp;\u0026plusmn;\u0026thinsp;18.6 \u0026micro;m in MS participants, PSS participants and HCs, respectively, and was not different from PSS participants in MS participants (p\u0026thinsp;=\u0026thinsp;0.378) but was lower than in HCs (p\u0026thinsp;=\u0026thinsp;0.002). Retinal thickness in the parafoveal area was significantly lower in MS participants than in PSS participants and HCs in all regions (inferior, superior, nasal, temporal). Retinal thickness in the perifoveal area was significantly lower in MS participants in the inferior, superior and nasal regions than in PSS participants and HCs. However, although retinal thickness in the temporal region of the perifoveal area was significantly lower in MS participants than in PSS participants (p\u0026thinsp;=\u0026thinsp;0.008), it was not different from that in HCs (p\u0026thinsp;=\u0026thinsp;0.067). Foveal volume was 6.95\u0026thinsp;\u0026plusmn;\u0026thinsp;0.51, 7.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.75, and 7.19\u0026thinsp;\u0026plusmn;\u0026thinsp;0.34 mm\u0026sup3; in MS participants, PSS participants, and HCs, respectively, and was lower in MS participants than in PSS participants and HCs (p\u0026thinsp;=\u0026thinsp;0.001, p\u0026thinsp;=\u0026thinsp;0.003, respectively).\u003c/p\u003e\u003cp\u003eFigure \u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e1\u003c/span\u003e: Schematic representation of RNFL and macular thickness in HC, PSS and MS\u003c/p\u003e\u003c/div\u003e\u003c/div\u003e\u003cdiv id=\"Sec13\" class=\"Section2\"\u003e\u003ch2\u003eComparison of MS participants and PSS participants with CNS involvement\u003c/h2\u003e\u003cp\u003eComparison of OCT measurements of MS participants and PSS participants with CNS involvement is shown in Table-4. Whole RNFL thickness was 88.8\u0026thinsp;\u0026plusmn;\u0026thinsp;12.5 and 93.1\u0026thinsp;\u0026plusmn;\u0026thinsp;11.9 \u0026micro;m in MS participants and PSS participants with CNS involvement, respectively. Whole GCC thickness was 85.8\u0026thinsp;\u0026plusmn;\u0026thinsp;14.4 and 90.9\u0026thinsp;\u0026plusmn;\u0026thinsp;6.2 \u0026micro;m in MS participants and PSS participants with CNS involvement, respectively. Foveal thickness was 244.7\u0026thinsp;\u0026plusmn;\u0026thinsp;19.1 and 255.4\u0026thinsp;\u0026plusmn;\u0026thinsp;35.9 \u0026micro;m in MS participants and PSS participants with CNS involvement, respectively. Retinal thickness in the RNFL, GCC, fovea and perifovea areas was not different in MS participants than in PSS participants with CNS involvement in any region. However, retinal thickness in the superior, inferior, and temporal regions of the parafovea area was significantly lower in MS participants than in PSS participants with CNS involvement (p\u0026thinsp;=\u0026thinsp;0.031, p\u0026thinsp;=\u0026thinsp;0.017, and p\u0026thinsp;=\u0026thinsp;0.012, respectively). Foveal volume was 6.95\u0026thinsp;\u0026plusmn;\u0026thinsp;0.51 and 7.27\u0026thinsp;\u0026plusmn;\u0026thinsp;0.63 mm\u0026sup3; in MS participants and PSS participants with CNS involvement, respectively, and the difference was not significant (p\u0026thinsp;=\u0026thinsp;0.097). Comparison of OCT measurements between MS participants with and without ON and participants with PSS with CNS involvement is shown in Table-5. RNFL and GCC thickness was not different between PSS participants with CNS involvement and MS participants with or without ON in any region. Retinal thickness in parafovea and perifovea areas was different between 3 groups in all regions. In post hoc analysis, retinal thickness was found to be lower in the nasal and temporal regions of both parafovea (p\u0026thinsp;=\u0026thinsp;0.024 and p\u0026thinsp;=\u0026thinsp;0.040, respectively) and perifovea (p\u0026thinsp;=\u0026thinsp;0.018 and p\u0026thinsp;=\u0026thinsp;0.016, respectively) areas in MS patients with ON than in MS patients without ON. Compared with PSS participants with CNS involvement, MS participants with ON exhibited significantly reduced retinal thickness in the superior (p\u0026thinsp;=\u0026thinsp;0.026), inferior (p\u0026thinsp;=\u0026thinsp;0.017), and nasal (p\u0026thinsp;=\u0026thinsp;0.039) parafoveal regions, as well as in the inferior (p\u0026thinsp;=\u0026thinsp;0.019), nasal (p\u0026thinsp;=\u0026thinsp;0.001), and temporal (p\u0026thinsp;=\u0026thinsp;0.001) perifoveal regions. In the comparison between MS participants without ON and PSS participants with CNS involvement, retinal thickness was not different in any region of any area. While retinal thickness in the foveal area was not different between groups, foveal volume was found to be lower in MS participants with ON than in PSS participants with CNS involvement (p\u0026thinsp;=\u0026thinsp;0.017).\u003c/p\u003e\u003c/div\u003e"},{"header":"DISCUSSION","content":"\u003cp\u003eIn clinical practice, several disorders with CNS involvement can mimic MS both clinically and radiologically. Among them, autoimmune connective tissue diseases such as primary Sj\u0026ouml;gren\u0026rsquo;s syndrome may present with white matter lesions, episodes suggestive of demyelination, or even optic neuritis, which can lead to misdiagnosis. In such scenarios, additional biomarkers that reflect neuroaxonal damage and can be obtained in a quick and non-invasive manner are highly desirable. OCT has been proposed as one such tool, because it allows direct visualization and quantification of retinal layers that correspond to unmyelinated axons and neurons of the CNS. On this basis, we aimed to investigate whether OCT parameters could help distinguish MS from PSS and from healthy individuals.\u003c/p\u003e\u003cp\u003e Our study showed RNFL thickness was found to be significantly lower in MS participants than in PSS participants and HCs in all RNFL regions (superior, inferior, temporal) except the nasal region. Whole GCC thickness was significantly lower in MS participants than in PSS participants and HC. Foveal volume was lower in MS participants than in PSS participants and HCs. When MS patients were compared with PSS with CNS involvement; retinal thickness were found to be lower only in the parafoveal region in MS patients. Also foveal volume was found to be lower in MS participants with ON than in PSS participants with CNS involvement (p\u0026thinsp;=\u0026thinsp;0.017).\u003c/p\u003e\u003cp\u003eOCT findings were similar when MS patients without ON and PSS patients with CNS lesions were compared. In MS patients with ON, retinal thicknesses were found to be lower in the parafoveal and perifoveal area in MS patients compared to PSS patients with CNS lesions. When the retinal thicknesses of all MS patients and PSS patients with CNS lesions were compared, retinal thickness was found to be lower in the parafoveal region in MS patients. It can be interpreted that the parafoveal region is prominent in the differential diagnosis of MS patients from PSS patients with CNS involvement. Parafoveal region seems to be important in differential diagnosis of MS.\u003c/p\u003e\u003cp\u003eOur findings are in line with previous work that evaluated OCT for the differential diagnosis of MS and autoimmune connective tissue diseases with CNS involvement. In the study by Wildner et al., OCT measurements were compared among MS patients, patients with CNS involvement in connective tissue diseases, and healthy controls, and significant group effects were demonstrated for peripapillary RNFL and macular parameters, supporting the concept that retinal structural changes may reflect disease-specific patterns of CNS injury [10]. Similar to that study, we observed that MS patients showed more pronounced RNFL thinning than PSS participants and healthy controls, particularly in the superior, inferior, and temporal quadrants, whereas the nasal quadrant was relatively preserved.\u003c/p\u003e\u003cp\u003e OCT has substantially improved our understanding of the pathophysiological mechanisms in MS. Several studies have shown that thinning of the RNFL and ganglion cell\u0026ndash;inner plexiform layer (GCIPL) occurs not only after ON but also in eyes without a history of optic nerve inflammation, indicating that retinal neuroaxonal loss is a diffuse manifestation of CNS pathology rather than a purely local phenomenon. These structural changes correlate with visual dysfunction and, in many reports, with global measures of disability, supporting the use of OCT as a biomarker of neurodegeneration in MS (\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e). The observation of RNFL and macular thinning in our MS cohort, including eyes without ON, is consistent with this concept.\u003c/p\u003e\u003cp\u003eRecent revisions of the McDonald diagnostic criteria (2024) have now formally incorporated the visual system into the diagnostic framework (\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e). The optic nerve is recognized as a fifth topographic site for dissemination in space, and abnormal findings on orbital MRI, visual evoked potentials or OCT can all provide paraclinical evidence of optic nerve involvement when no better explanation exists. Within these revisions, OCT-derived inter-eye differences in peripapillary RNFL and macular ganglion cell\u0026ndash;inner plexiform layer thickness are specifically recommended as supportive measures to document unilateral optic nerve damage. In this updated context, our results suggest that quantitative retinal structural measurements obtained by OCT not only reflect neuroaxonal damage in MS but may also help to document optic nerve involvement and to distinguish MS from PSS with CNS involvement in diagnostically challenging cases, especially when conventional MRI findings are equivocal (\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eBeyond structural OCT, optical coherence tomography angiography (OCTA) has emerged as a promising technique to assess retinal microvasculature in systemic autoimmune diseases. Several studies have reported reduced vessel density in the superficial and deep capillary plexus in MS and in PSS, even in the absence of overt ocular disease. Recently, Wolf et al. used OCTA to directly compare patients with relapsing\u0026ndash;remitting MS and patients with PSS and demonstrated distinct patterns of retinal vascular alteration in the two diseases, suggesting that MS and PSS are associated with different retinal pathologies at the microvascular level (\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e). Although our study did not include OCTA measurements, the structural thinning of RNFL and macular layers that we observed in MS compared with PSS and healthy controls may represent the neuroaxonal counterpart of these microvascular abnormalities.\u003c/p\u003e\u003cp\u003eThis study has some limitations that should be acknowledged. The study population was of moderate size and the subgroup of PSS patients with CNS involvement was relatively small, which may have limited our ability to detect more subtle differences in OCT parameters between the groups. In addition, the single-center, cross-sectional design does not capture longitudinal change and may restrict the generalizability of the results. We also focused exclusively on structural OCT measures and did not include OCT angiography, so possible microvascular alterations could not be directly evaluated in this cohort. Finally, although key demographic and clinical factors were considered, the influence of unmeasured confounders cannot be completely excluded. These considerations may help to guide future research, including larger multicenter cohorts and longitudinal studies that combine structural OCT with OCT angiography to further clarify the diagnostic and prognostic value of retinal imaging in MS and PSS.\u003c/p\u003e\u003cp\u003eOur findings, in concordance with previous reports, indicate that OCT-derived retinal biomarkers may assist in differentiating MS, PSS with CNS involvement, and healthy individuals. Structural OCT yields quantitative measures of neuroaxonal damage, whereas OCTA provides complementary information on retinal microvascular alterations. Future studies that integrate both modalities in larger cohorts with longitudinal follow-up are warranted to clarify the interplay between structural and vascular retinal changes and to determine whether their combined use can enhance the early and accurate diagnosis of MS in patients with overlapping clinical or radiological features.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eOn behalf of all authors, the corresponding author states that there is no conflict of interest.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eBalcer LJ (2006) Clinical practice. Optic neuritis. N Engl J Med 354(12):1273\u0026ndash;1280\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eArnold AC (2005) Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 139(6):1101\u0026ndash;1108\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eForoozan R, Buono LM, Savino PJ, Sergott RC (2002) Acute demyelinating optic neuritis. Curr Opin Ophthalmol 13(6):375\u0026ndash;380\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eFrohman EM, Frohman TC, Zee DS, McColl R, Galetta S (2005) The neuro-ophthalmology of multiple sclerosis. Lancet Neurol 4(2):111\u0026ndash;121\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBritze J, Frederiksen JL (2018) Optical coherence tomography in multiple sclerosis. Eye (Lond) 32(5):884\u0026ndash;888. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41433-017-0010-2\u003c/span\u003e\u003cspan address=\"10.1038/s41433-017-0010-2\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003eEpub 2018 Feb 2. PMID: 29391574; PMCID: PMC5944645\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eAumann S, Donner S, Fischer J, Muller F Optical Coherence Tomography (OCT): Principle and Technical Realization. In: Bille JF, editor. High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics. Cham (CH)2019. pp. 59\u0026ndash;85\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eThompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G et al (2018) Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 17(2):162\u0026ndash;173\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eShiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM et al (2017) 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjogren's syndrome: A consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis 76(1):9\u0026ndash;16\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eKurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444\u0026ndash;1452\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eWildner P, Zydorczak E, Oset M, Siger M, Wilczyński M, Stasiołek M, Matysiak M (2020) The role of optical coherence tomography in differential diagnosis of multiple sclerosis and autoimmune connective tissue diseases with CNS involvement. J Clin Med 9(5):1565. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3390/jcm9051565\u003c/span\u003e\u003cspan address=\"10.3390/jcm9051565\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eWolf E, Wicklein R, Aly L, Schmaderer C, Afzali AM, Mardin C, Korn T, Hemmer B, Hofauer B, Knier B (2024) Optical coherence tomography angiography suggests different retinal pathologies in multiple sclerosis and Sj\u0026ouml;gren\u0026rsquo;s syndrome. J Neurol 271(7):4610\u0026ndash;4619. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1007/s00415-024-12414-0\u003c/span\u003e\u003cspan address=\"10.1007/s00415-024-12414-0\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMontalban X, Lebrun-Fr\u0026eacute;nay C, Oh J, Arrambide G, Moccia M, Pia Amato M, Amezcua L, Banwell B, Bar-Or A, Barkhof F, Butzkueven H, Ciccarelli O, Chataway J, Cohen JA, Comi G, Correale J, Deisenhammer F, Filippi M, Fiol J, Freedman MS, Fujihara K, Granziera C, Green AJ, Hartung HP, Hellwig K, Kappos L, Kimbrough D, Killestein J, Lublin F, Marignier R, Ann Marrie R, Miller A, Otero-Romero S, Ontaneda D, Ramanathan S, Reich D, Rocca MA, Rovira \u0026Agrave;, Saidha S, Salter A, Sastre-Garriga J, Saylor D, Solomon AJ, Sormani MP, Stankoff B, Tintore M, Tremlett H, Van der Walt A, Viswanathan S, Wiendl H, Wildemann B, Yamout B, Zaratin P, Calabresi PA, Coetzee T, Thompson AJ (2025) Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. ;24(10):850\u0026ndash;865. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/S1474-4422(25)00270-4\u003c/span\u003e\u003cspan address=\"10.1016/S1474-4422(25)00270-4\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e. Erratum in: Lancet Neurol. 2025;24(11):e13. doi: 10.1016/S1474-4422(25)00355-2. PMID: 40975101\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSaidha S, Green AJ, Leocani L, Vidal-Jordana A, Kenney RC, Bsteh G, Outteryck O, Thompson A, Montalban X, Coetzee T, Petzold A, Paul F, Balcer LJ, Calabresi PA (2025) The use of optical coherence tomography and visual evoked potentials in the 2024 McDonald diagnostic criteria for multiple sclerosis. Lancet Neurol. ;24(10):880\u0026ndash;892. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/S1474-4422(25)00275-3\u003c/span\u003e\u003cspan address=\"10.1016/S1474-4422(25)00275-3\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e. Erratum in: Lancet Neurol. 2025;24(11):e13. doi: 10.1016/S1474-4422(25)00349-7. PMID: 40975103\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"},{"header":"Tables","content":"\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"No\" id=\"Taba\" border=\"1\"\u003e\u003ccolgroup cols=\"4\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"4\" nameend=\"c4\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTable-1: Demographic data, clinical and laboratory characteristics of MS participants, and the drugs they use.\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003emean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMedian\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003emin-max\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAge at disease onset\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e31.7\u0026thinsp;\u0026plusmn;\u0026thinsp;7.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e31.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.0\u0026ndash;48.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAge\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e42.5\u0026thinsp;\u0026plusmn;\u0026thinsp;6.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e41.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e33.0\u0026ndash;64.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eDisease duration, years\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e10.8\u0026thinsp;\u0026plusmn;\u0026thinsp;5.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e10.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e1.0\u0026ndash;22.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFlairs/year\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.5\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.0\u0026ndash;3.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTreatment duration, years\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e9.0\u0026thinsp;\u0026plusmn;\u0026thinsp;6.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e9.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.0\u0026ndash;20.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eEDSS\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e2.3\u0026thinsp;\u0026plusmn;\u0026thinsp;1.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e2.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.0-5.5\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eFrequencies, n (%)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFemale\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e26 (86.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eClinic at disease onset\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003emono-symptomatic\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e8 (26.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003epoly-symptomatic\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e22 (73.3)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eOptic neuritis\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003enot present\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e11 (36.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eright\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3 (10.0)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eleft\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5 (16.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ebilateral\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e11 (36.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eDrugs\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003einterferon-β\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e9 (30.0)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003efingolimod\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e8 (26.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eglatiramer acetate\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5 (16.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eteriflunomide\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3 (10.0)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003erituximab\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e1 (3.3)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eno medication\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e4 (13.3)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"4\"\u003eMS: Multiple sclerosis, SD: standard deviation, min: minimum, max: maximum, EDSS: Expanded Disability Status Scale.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"No\" id=\"Tabb\" border=\"1\"\u003e\u003ccolgroup cols=\"4\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"4\" nameend=\"c4\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTable-2: Demographic data and clinical, laboratory and salivary gland pathological results of PSS participants, and the drugs they use.\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003emean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003emedian\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003emin-max\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAge at disease onset, years\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e40.5\u0026thinsp;\u0026plusmn;\u0026thinsp;9.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e40.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e17.0\u0026ndash;55.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAge, years\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e47.2\u0026thinsp;\u0026plusmn;\u0026thinsp;6.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e45.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e33.0\u0026ndash;58.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eDisease duration, years\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.7\u0026thinsp;\u0026plusmn;\u0026thinsp;5.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e5.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e2.0\u0026ndash;23.0\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFemale, n (%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e28 (100)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eSicca symptoms, n (%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eoral\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e22 (78.6)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eocular\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e24 (85.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eRaynaud, n (%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e7 (25.0)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eCNS involvement, n (%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e7 (25.0)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eMinor salivary gland biopsy\u003csup\u003e\u0026Dagger;\u003c/sup\u003e, n\u0026thinsp;=\u0026thinsp;21\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003egrade 0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003egrade 1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003egrade 2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003egrade 3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003egrade 4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e12\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAntibodies, positive, n (%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eANA\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e27 (96.4)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAnti-SSA\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e22 (78.6)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAnti-SSB\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e10 (35.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eRF\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e12 (42.9)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eDrugs, n (%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ehydroxychloroquine\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e26 (92.9)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003epilocarpine\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e2 (7.1)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003emethotrexate\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3 (10.7)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ecorticosteroids\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e16 (57.1)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eazathioprine\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5 (17.9)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003epregabalin\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e7 (25.0)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eduloxetine\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e4 (14.3)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"4\"\u003ePSS: Primary Sj\u0026ouml;gren's syndrome, SD: standard deviation, CNS: central nerves system, \u003csup\u003e\u0026Dagger;\u003c/sup\u003eaccording to Chisholm score, ANA: antinuclear antibody, SSA: Sj\u0026ouml;gren\u0026rsquo;s syndrome A, SSB: Sj\u0026ouml;gren\u0026rsquo;s syndrome B, RF: Rheumatoid factor.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"No\" id=\"Tabc\" border=\"1\"\u003e\u003ccolgroup cols=\"12\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c10\" colnum=\"10\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c11\" colnum=\"11\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c12\" colnum=\"12\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"12\" nameend=\"c12\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTable-3: Comparison of OCT measurements of MS participants patients with PSS participants and HCs.\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c4\" namest=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003eMS (n\u0026thinsp;=\u0026thinsp;60)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c7\" namest=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ePSS (n\u0026thinsp;=\u0026thinsp;56)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c10\" namest=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003eHCs (n\u0026thinsp;=\u0026thinsp;54)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ep1\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ep2\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eThickness, mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c4\" namest=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c7\" namest=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c10\" namest=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eRNFL, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e88.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e12.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e101.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e10.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e98.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e8.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e100.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e116.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e118.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e11.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e101.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e17.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e116.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e118.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e76.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e79.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e10.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e81.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e17.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.400\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.238\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e63.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e76.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e11.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e74.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e10.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eGCC, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e85.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e95.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e95.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e85.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e13.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e95.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e95.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e86.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e95.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e96.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e244.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e249.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e22.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e256.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.378\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.002\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eParafovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e305.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e39.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e320.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e45.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e314.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e16.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e300.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e37.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e323.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e45.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e317.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e16.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e299.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e23.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e320.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e46.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e315.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e16.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e291.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e23.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e311.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e41.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e305.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e16.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.001\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ePerifovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e270.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e21.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e284.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e32.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e277.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.003\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.021\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e278.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e293.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e26.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e286.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.009\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e287.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e26.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e303.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e34.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e300.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e16.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.000\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e271.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e25.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e281.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e25.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e275.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.008\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.067\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFV, mm\u0026sup3;, mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.95\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.51\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.33\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.75\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.19\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.34\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.003\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"12\" nameend=\"c12\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eOCT: optical coherence tomography, MS: multiple sclerosis, PSS: Primary Sj\u0026ouml;gren's syndrome, HCs: healthy controls, SD: standard deviation, RNFL: retinal nerve fiber layer, GCC: ganglion cell complex, FV: fovea volume.\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003ep1: MS vs SS\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003ep2: MS vs controls\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"No\" id=\"Tabd\" border=\"1\"\u003e\u003ccolgroup cols=\"9\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"9\" nameend=\"c9\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTable-4: Comparison of OCT measurements of MS participants and PSS participants with CNS involvement.\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c4\" namest=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003eMS\u003c/span\u003e\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003e(n\u0026thinsp;=\u0026thinsp;60)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c8\" namest=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ePSS with CNSL\u003c/span\u003e\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003e(n\u0026thinsp;=\u0026thinsp;14)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ep\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eThickness, mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c4\" namest=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c8\" namest=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eRNFL, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e88.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e12.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e93.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e11.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.265\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e100.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e105.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e22.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.233\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e101.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e17.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e109.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.155\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e76.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e72.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e9.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.628\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e63.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e70.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e9.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.106\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eGCC, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e85.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e90.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.106\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e85.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e13.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e89.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e5.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.165\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e86.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e92.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.077\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e244.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e255.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e35.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.537\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eParafovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e305.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e39.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e318.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e41.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.077\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e300.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e37.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e322.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e40.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.031\u003csup\u003e*\u003c/sup\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e299.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e23.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e318.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e25.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.017\u003csup\u003e*\u003c/sup\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e291.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e23.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e311.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e22.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.012\u003csup\u003e*\u003c/sup\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ePerifovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e270.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e21.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e286.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e38.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.098\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e278.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e297.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e47.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.253\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e287.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e26.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e298.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e27.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.075\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e271.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e25.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e278.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.101\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFV, mm\u0026sup3;, mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.95\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.51\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.27\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.63\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.097\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"9\"\u003eOCT: optical coherence tomography, pr: parameters, MS: multiple sclerosis, PSS: Primary Sj\u0026ouml;gren's syndrome, CNSL: central nervous system lesion, SD: standard deviation, RNFL: retinal nerve fiber layer, GCC: ganglion cell complex, FV: fovea volume, \u003csup\u003e*\u003c/sup\u003ep\u0026thinsp;\u0026lt;\u0026thinsp;0.05.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"No\" id=\"Tabe\" border=\"1\"\u003e\u003ccolgroup cols=\"14\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c10\" colnum=\"10\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c11\" colnum=\"11\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c12\" colnum=\"12\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c13\" colnum=\"13\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c14\" colnum=\"14\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"14\" nameend=\"c14\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTable-5: Comparison of OCT measurements between MS participants with and without optic neuritis and participants with Primary Sj\u0026ouml;gren's syndrome with central nervous system lesion.\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colspan=\"6\" nameend=\"c7\" namest=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003eMS\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" morerows=\"1\" nameend=\"c10\" namest=\"c8\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ePSS with CNSI\u003c/span\u003e\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003e(n\u0026thinsp;=\u0026thinsp;14)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ep1\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003csup\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003e\u0026Dagger;\u003c/span\u003e\u003c/sup\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ep2\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003csup\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003e\u0026Dagger;\u003c/span\u003e\u003c/sup\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ep3\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003csup\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003e\u0026Dagger;\u003c/span\u003e\u003c/sup\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003ep4\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c4\" namest=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003eON- (n\u0026thinsp;=\u0026thinsp;30)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c7\" namest=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Bold\" class=\"Bold\" name=\"Emphasis\"\u003eON+ (n\u0026thinsp;=\u0026thinsp;30)\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eThickness, mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eRNFL, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e90.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e13.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e86.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e11.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e93.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e11.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.239\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.440\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.258\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.818\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e102.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e21.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e98.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e105.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e22.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.441\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.639\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.454\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.879\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e103.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e100.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e109.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.304\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.724\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.274\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.616\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e80.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e73.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e72.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e9.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.289\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.360\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.982\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.406\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e65.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e16.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e61.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e12.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e70.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e9.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.144\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.468\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.133\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.583\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eGCC, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e88.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e16.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e83.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e11.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e90.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.144\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.287\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.176\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.827\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e87.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e14.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e82.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e11.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e89.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e5.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.142\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.263\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.185\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.863\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e89.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e83.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e12.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e92.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.165\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.333\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.192\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.811\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e250.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e17.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e238.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e255.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e35.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.051\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.139\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.073\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.768\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eParafovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e277.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e23.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e263.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e17.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e286.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e38.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.014\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.093\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.017\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.499\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e282.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e274.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e18.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e297.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e47.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.034\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.538\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.026\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.172\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e295.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e28.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e278.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e298.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e27.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.011\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.024\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.039\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.936\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e278.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e25.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e263.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e23.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e278.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.032\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.040\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.132\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.999\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ePerifovea, \u0026micro;m\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003einferior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e317.0\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e47.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e293.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e22.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e318.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e41.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.033\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.051\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.104\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.986\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003esuperior\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e310.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e25.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e289.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e44.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e322.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e40.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.014\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.080\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.019\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.561\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003enasal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e307.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e22.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e290.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e318.2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e25.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.001\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.018\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.001\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.296\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003etemporal\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e299.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e19.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e282.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e24.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e311.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e22.9\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.000\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.016\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.001\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.216\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFV, mm\u0026sup3;, mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.4\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e6.8\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e7.3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026plusmn;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c10\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.6\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c11\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.011\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c12\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.061\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c13\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003e0.017\u003c/span\u003e\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c14\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.590\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"14\" nameend=\"c14\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eOCT: optical coherence tomography, MS: multiple sclerosis, ON: optic neuritis, PSS: Primary Sj\u0026ouml;gren's syndrome, CNSI: central nervous system involvement \u003csup\u003e\u0026Dagger;\u003c/sup\u003epost hoc analysis, SD: standard deviation, RNFL: retinal nerve fiber layer, GCC: ganglion cell complex, FV: foveal volume\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003eP1: MS/ON- \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003evs\u003c/span\u003e MS/ON\u0026thinsp;+\u0026thinsp;\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003evs\u003c/span\u003e PSS\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003ep2: MS/ON- \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003evs\u003c/span\u003e MS/ON+\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003eP3: MS/ON\u0026thinsp;+\u0026thinsp;\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003evs\u003c/span\u003e PSS\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003eP4: MS/ON- \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003evs\u003c/span\u003e PSS\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"multiple sclerosis, primary Sjögren’s syndrome, optical coherence tomography, retinal nerve fiber layer, optic neuritis","lastPublishedDoi":"10.21203/rs.3.rs-8139231/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8139231/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e\u003cp\u003ePrimary Sj\u0026ouml;gren\u0026rsquo;s syndrome (PSS) with central nervous system (CNS) involvement can mimic multiple sclerosis (MS). Optical coherence tomography (OCT) quantifies retinal neuroaxonal damage and may assist differential diagnosis.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003eIn this case\u0026ndash;control study, 170 eyes (60 from participants with MS, 56 from PSS, and 54 from healthy controls [HCs]) were examined with OCT. Peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and foveal, parafoveal and perifoveal retinal thicknesses and foveal volume were measured. Group comparisons, including subgroup analyses of MS with and without previous optic neuritis (ON) and PSS with CNS involvement, used parametric or non-parametric tests (significance p\u0026thinsp;\u0026lt;\u0026thinsp;0.05).\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eWhole RNFL and GCC thickness were significantly lower in MS than in PSS and HCs, with RNFL thinning in all quadrants except nasal. MS showed lower parafoveal and perifoveal retinal thickness and reduced foveal volume compared to PSS and HCs. When MS was compared with PSS with CNS involvement, parafoveal thickness remained significantly lower in MS, whereas other OCT parameters were similar. In three-group analyses, MS with prior ON showed the most pronounced parafoveal and perifoveal thinning versus MS without ON and PSS with CNS involvement, while MS without ON did not differ from PSS with CNS involvement.\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e\u003cp\u003eOCT demonstrates more extensive retinal neuroaxonal damage in MS than in PSS and HCs, especially in peripapillary RNFL and parafoveal/perifoveal macula. These findings support the potential role of OCT in differentiating MS from PSS with CNS involvement and in identifying MS patients with more severe neuroaxonal injury.\u003c/p\u003e","manuscriptTitle":"Optical coherence tomography findings in multiple sclerosis and comparison with Primary Sjögren’s syndrome","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-19 12:13:55","doi":"10.21203/rs.3.rs-8139231/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"cd6913d2-bb50-4804-a531-3d8e3734d538","owner":[],"postedDate":"November 19th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":58145192,"name":"Neurology"}],"tags":[],"updatedAt":"2025-11-19T12:13:55+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-19 12:13:55","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8139231","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8139231","identity":"rs-8139231","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}