The Establishment of Endometriosis Model in Rats and it′s Histological Observation

Objective To establish the experimental endometriosis in rats and study it′s histological structure. Methods Endometriosis was surgically induced in 80 SD rats, The growth of the transplant and rats' estrus cycle was observed in different times after the implantation operation. The endometrum of the uninjured side and the ectopic endometrum were taken for observing by microscope and electroscope. Results There was 65% transplant to develop. The inner wall of the cyst had endometrum epithelial cells, and it altered cycle with the normal endometrum. The cyst enlarged gradually at first and had contracted tendency after that, and cysts on the utero ligament were bigger than ones on the mesentery in the same time. Conclusion The model of endometriosis in rat established by implanting the self endometrum to utero ligament or mesentery is the convenient method to study and research the endometriosis. This ectopic endometrum can change correspond to the reproductive cycle, and has physiological functions alike the normal endometrum.