High-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect

High-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article High-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect Longzhen Qiu, Xiaocheng Wu, Junjie Liu, Fan Ni, Longlong Jiang, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6365515/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 26 Sep, 2025 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Abstract The chirality-induced spin selectivity (CISS) effect is a state-of-art strategy for chiral detectability enhancement. For the first time, high-performance gas-phase chiral detectors based on the CISS effect were prepared using organic polymer, to address the challenges in accurately and portably detecting gas-phase chiral enantiomers in analytical chemistry. Here, a series of block copolymers poly(3-hexylthiophene)-block poly(phenyl isocyanate) (P3HT-PPI) were synthesized, combining a chiral helical structure and significantly improved electrical conductivity to regulate CISS effect by PPI ratio for precise, portable chiral recognition. P3HT80-PPI30 demonstrates exceptional spin polarization up to 70.8%. The gas enantiomer detector based on P3HT80-PPI30 exhibits excellent chiral distinguish capability of limonene enantiomers with current asymmetry factor up to 0.50, real-time detection, high reversibility, and linear concertation-dependence of response. An ‘electronic dichroism’ system based on the circuit combining chiral and achiral sensing elements, was developed for real-time visualization of limonene enantiomeric excess. Designing materials with CISS effect incorporating spin-polarized electrons in chiral enantiomer recognition and combing with conductive properties for converting chemical signals to electrical outputs, provides an effective strategy for the next-generation real-time, efficient detection of multiple chiral enantiomers. Physical sciences/Physics/Electronics, photonics and device physics/Electronic and spintronic devices Physical sciences/Materials science/Materials for devices/Sensors and biosensors chiral organic semiconductors spintronics gas-phase chiral enantiomer detectors self-assembly electronic dichroism Full Text Additional Declarations There is NO Competing Interest. Supplementary Files SupportingInformatio.docx Supporting Information ED.mp4 Video S1. Demonstration of the process of differentiating the enantiomeric components of limonene Cite Share Download PDF Status: Published Journal Publication published 26 Sep, 2025 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6365515","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":440354508,"identity":"2b96e7f6-0c3b-4f5c-b946-fc69a53bf0c5","order_by":0,"name":"Longzhen Qiu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyUlEQVRIie3NsQrCMBCA4SuFdjnNmslnqAhSUHyWhIJuOgidO3XKAxR8GFOyalwrOlh8Accugq1FcBDSbg754SAH9xEAm+0PGwICMJgzP2lWrwPxWrJkKN0+BED1IeSYF2V6WiPdSHjECsguMf2io5Cnly3SCJxMK6BXaSCOmNKa8H1N3EGqIKDMQFxsiOaiIc9OxHsT2RKnE0GchExHXOA9yIVeIS0MhJDD+FzFCy58Xt6qeDYimYE00c9D1oPm+29is9lstp+9ANhvPCdMRrc7AAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-8356-6303","institution":"Hefei University of Technology","correspondingAuthor":true,"prefix":"","firstName":"Longzhen","middleName":"","lastName":"Qiu","suffix":""},{"id":440354509,"identity":"c21ba65a-dd95-4e68-95f8-f332a93d9450","order_by":1,"name":"Xiaocheng Wu","email":"","orcid":"","institution":"Hefei University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Xiaocheng","middleName":"","lastName":"Wu","suffix":""},{"id":440354510,"identity":"15636ffb-1e8b-4641-9d98-487dd67b0f97","order_by":2,"name":"Junjie Liu","email":"","orcid":"","institution":"Hefei University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Junjie","middleName":"","lastName":"Liu","suffix":""},{"id":440354511,"identity":"62aa3c5c-7030-4865-a494-d6211cdc9fef","order_by":3,"name":"Fan Ni","email":"","orcid":"","institution":"Hefei University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Fan","middleName":"","lastName":"Ni","suffix":""},{"id":440354512,"identity":"12a13fa0-fb6e-48ad-b078-4e962130a5e6","order_by":4,"name":"Longlong Jiang","email":"","orcid":"","institution":"Fuyang Normal University","correspondingAuthor":false,"prefix":"","firstName":"Longlong","middleName":"","lastName":"Jiang","suffix":""},{"id":440354513,"identity":"ca5bb86d-7b3c-4a5e-b431-53036a5fb3aa","order_by":5,"name":"Shiyu Wei","email":"","orcid":"","institution":"Hefei University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Shiyu","middleName":"","lastName":"Wei","suffix":""},{"id":440354514,"identity":"a8fdeb6f-7996-4417-8a3f-edfdcfd20a2a","order_by":6,"name":"Xiaohong Wang","email":"","orcid":"","institution":"Hefei University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Xiaohong","middleName":"","lastName":"Wang","suffix":""}],"badges":[],"createdAt":"2025-04-03 03:40:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6365515/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6365515/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41467-025-63347-9","type":"published","date":"2025-09-26T04:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":92305110,"identity":"fbb0b406-6e6a-4b19-82dc-a0409f7de51c","added_by":"auto","created_at":"2025-09-27 07:09:55","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1275339,"visible":true,"origin":"","legend":"Article File","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6365515/v1_covered_0f0e1fe8-696c-4b2c-87fb-d38efd2abc48.pdf"},{"id":82581993,"identity":"b04beb28-6394-44f4-b171-741bb48581b3","added_by":"auto","created_at":"2025-05-13 06:40:14","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":3587291,"visible":true,"origin":"","legend":"Supporting Information","description":"","filename":"SupportingInformatio.docx","url":"https://assets-eu.researchsquare.com/files/rs-6365515/v1/c1e5212a520a70e215101bd5.docx"},{"id":82581994,"identity":"165cdc80-b723-4a33-bce6-a3c8a8d0d50d","added_by":"auto","created_at":"2025-05-13 06:40:14","extension":"mp4","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":15969724,"visible":true,"origin":"","legend":"Video S1. 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