Across-cities transportable 13C hyperpolarization using UV-induced labile radicals

Across-cities transportable 13C hyperpolarization using UV-induced labile radicals | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Across-cities transportable 13 C hyperpolarization using UV-induced labile radicals Andrea Capozzi, Magnus Karlsson, Yupeng Zhao, Jan Kilund, Esben Hansen, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6490603/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Hyperpolarized 13 C Magnetic Resonance Spectroscopic Imaging (HP 13 C-MRSI) has the potential to transform diagnostic radiology thanks to its unique ability to noninvasively detect a broad range of diseases entailing aberrant metabolism. However, clinical adoption has been hindered by the short lifetime of 13 C-hyperpolarization and the resulting need for on-site polarizers near the MR scanner. In this work, we present a solution for long-lived transportable HP molecular contrast agents that uses dissolution Dynamic Nuclear Polarization (dDNP) combined with UV-induced labile radicals. This approach allows centralized pre-polarization and transport under hours-long storage T1 conditions. We validate this concept through the first across-cities HP 13 C-MRSI experiments in vivo on a clinical MRI system, using both a perfusion/angiography agent ([1- 13 C]HP001) and a metabolic ([U- 13 C, d7]glucose) contrast agent. Our findings advance the feasibility of decentralized, scalable HP MRI workflows, removing the barrier of on-site infrastructure and moving the field closer to clinical translation. Physical sciences/Physics/Techniques and instrumentation/NMR spectroscopy/Solution-state NMR Physical sciences/Physics/Chemical physics Health sciences/Oncology Full Text Additional Declarations Yes there is potential Competing Interest. Prof. Ardenkjær-Larsen is the owner of Polarize ApS. Dr Andrea Capozzi is currently employed by Polarize ApS. Polarize ApS sells dDNP equipment for pre-clinical studies. Supplementary Files 20250420AarhustransportSINatureComm.pdf Supplementary Information Supplementaryvideo1quench.mp4 Non-persistend radicals quench procedure Supplementaryvideo2extraction.mp4 Long-relaxing hyperpolarized sample extraction from polarizer Supplementaryvideo3transport.mp4 Long-relaxing hyperpolarized sample transport Supplementaryvideo4remotedissolution.mp4 Remote dissolution Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6490603","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":460308591,"identity":"a4d8c807-dfa2-40f6-bc21-f404fb2ce5c1","order_by":0,"name":"Andrea 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