Differences in gene expression of eutopic endometrium from healthy women and endometriosis patients

Ines Beyer, Ruan van Rensburg, S Boeddecker, JS Kruessel, Tanja Fehm, R. Gruemmer, AP Bielfeld
In: Geburtshilfe und Frauenheilkunde · 2016 · vol. 76(10) · doi:10.1055/s-0036-1592777 · W2530473271
article OA: closed CC0
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated differences in gene expression in eutopic endometrium between healthy women and those with endometriosis, considering the roles of angiogenesis, proliferation, and inflammation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The study analyzed gene-expression differences in eutopic endometrium between healthy women and endometriosis patients. Using scratch biopsies collected during diagnostic hysteroscopy and laparoscopy (and from endometrial scratching procedures in assisted reproduction), the authors quantified mRNA levels for a panel of genes related to proliferation, vascularization, and inflammation. The preliminary analysis found significant differences in gene expression between eutopic endometrium from healthy individuals and from endometriosis patients. The paper does not provide expanded results beyond this preliminary finding and states that further ongoing investigations are needed to elucidate the interplay of the regulated genes. This paper is centrally about endometriosis — it compares eutopic endometrium gene-expression profiles in endometriosis patients versus healthy controls, focusing on proliferation, angiogenesis, and inflammatory pathways.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Introduction: Endometriosis is one of the most common and, yet, underdiagosed disease in reproductive age women. Patients show very divergent signs of pain from none to severe with a magnitude mostly not correlated to the extent of the disease. Additionally, endometriosis is often associated with infertility. One of the pathomechanism theories is retrograde menstruation. The underlying conditon has, however, not been revealed so far. Furthermore, endometriotic lesions outside the uterus are not explained satisfactory by the aforementioned hypothesis. Processes of neoangiogenesis, proliferation and inflammation are considered to play an important roll in the development of endometriosis.
Full text 1,875 characters · extracted from oa-doi-fallback · 4 sections · click to expand

Introduction

Endometriosis is one of the most common and, yet, underdiagosed disease in reproductive age women. Patients show very divergent signs of pain from none to severe with a magnitude mostly not correlated to the extent of the disease. Additionally, endometriosis is often associated with infertility. One of the pathomechanism theories is retrograde menstruation. The underlying conditon has, however, not been revealed so far. Furthermore, endometriotic lesions outside the uterus are not explained satisfactory by the aforementioned hypothesis. Processes of neoangiogenesis, proliferation and inflammation are considered to play an important roll in the development of endometriosis. Aim: An analysis was performed to elucidate differences in the eutopic endometrium of healthy women and endometriosis patients.

Material and methods

Scratch biopsies of the eutopic endometrium were collected during diagnostic hysteroscopy and laparoscopy of healthy and endometriosis patients as well as from endometrial scratching procedures associated with assisted reproductive techniques. Subsequently, quantitative PCR was performed for a panel of genes associated with proliferation, vascularisation and inflammation.

Results

A preliminary analyses revealed significant differences in the gene expression between the eutopic endometrium collected from healthy individuals compared to biopsies collected from endometriosis patients.

Conclusions

In this first investigated collective we have found differences in the gene expression of the endometrium of healthy patients compared to endometiosis patients. Ongoing investigations will further support the current data and further elucidate the interplay of the regulated genes.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisinfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK