The Relativity of survivin and Adenomyosis

Objective To investigate the expression of survivin in normal human endometrium, and adenomyosis in order to study the function and relativity of apoptosis, cell proliferation and angiogenesis in the course of adenomyosis.Methods Specimens of normal endometrium, ectopic endometrial tissue and eutopic endometrial tissue in adenomyosis were obtained for immunohistochemical survivin, PCNA and endoglin analyses.Results The expression of survivin and microvessel density in ectopic endometrial tissue of adenomyosis was significantly higher than that of normal endometrium and eutopic endometrial tissue in adenomyosis ( P 0.01 ), survivin expression was significantly associated with endoglin expression in endometrium of proliferate phase and secretary phase( r = 0.612 , P 0.01 ).Conclusion The overexpression of survivin and survivin collected apoptosis and angiogenesis mechanism might play a pathogenic role in the development of adenomyosis.