Down-regulation of the FTO gene in follicular fluid of infertile women with ovarian endometriosis

Yanmei Li, Naihui Wang, Yuanxue Jing, Jiajing He, Fangfang Li, Xuehong Zhang
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2023 · vol. 39(1) , pp. 2269273 · doi:10.1080/09513590.2023.2269273 · PMID:37871609
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

Follicular fluid FTO concentrations and mRNA levels were significantly decreased in infertile women with ovarian endometriosis compared to controls, with increased m6A levels in granulosa cells.

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Abstract

OBJECTIVE: To evaluate FTO concentrations in follicular fluid (FF) of women with ovarian endometriosis (OE) and controls women without OE undergoing in vitro fertilization-embryo transfer (IVF-ET). METHODS: FTO concentrations in FF were measured in 74 patients (37 in the control group and 37 in the OE group) by ELISA. We measured the expression of FTO in GCs of 40 patients (19 in the control group and 21 in the OE group) by RT-qPCR. The level of m6A in GCs was measured in 20 patients (10 in the control group and 10 in the OE group) by colorimetry. RESULTS: Compared with the control group, FTO concentrations in FF (6.92 ± 0.44 vs. 5.67 ± 0.40 ng/ml) (p <.05) and FTO mRNA level in GCs of OE group were decreased significantly (p .05). CONCLUSIONS: The FTO concentrations in FF of infertility women with OE are decreased, which may be related to the impaired oocyte quality in endometriosis patients.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Alpha-Ketoglutarate-Dependent Dioxygenase FTO Alpha-Ketoglutarate-Dependent Dioxygenase FTO Alpha-Ketoglutarate-Dependent Dioxygenase FTO Alpha-Ketoglutarate-Dependent Dioxygenase FTO Down-Regulation Down-Regulation Down-Regulation Female Female

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europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
pubmed
last seen: 2026-05-16T00:33:09.872309+00:00
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last seen: 2026-05-14T19:30:52.867331+00:00
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