Relationship Between Obstetric Complications in Women Undergoing IVF with PCOS: A Retrospective Cohort Study

Abstract Background: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder. One of its complications is infertility. In Vitro Fertilization (IVF) is one of the alternatives to the problem. However, there are no study describing the differences in obstetric complications of PCOS patients undergoing IVF compared to other patients. This study aims to determine the relationship of obstruction complications in women undergoing IVF programs with PCOS.Methods: This was a retrospective cohort study conducted at Cipto Mangunkusumo National General Hospital on 2013-2019. The study subjects were all women aged over 18 years who underwent IVF programs without other gynecological abnormalities besides PCOS. The outcomes in this study were obstetric complications in the form of abortion. Analysis is done by using cox-regression to get the value of Hazard Ratio (HR) after controlling for confounding factors.Results: This study included 355 women, of whom 72 had PCOS (20.3%). Complications found in subjects with PCOS were preterm found in (2.78%), abortion (9.72%) and ectopic pregnancy (1.39%). No association was found between PCOS and abortion in women undergoing IVF programs (p-value > 0.05). Interaction between PCOS and cleavage ratio <6 had higher probability of having abortion in women undergoing IVF program obtained. (RR: 7.32, 95% CI: 2.10-25.45, P-value: 0.002).Conclusion: PCOS does not affect the occurrence of abortion in women undergoing IVF program.