Ethnobotanical Knowledge in the Primbon Padukunan Manuscripts: A Historical Ethnobotany from the Merapi–Merbabu Region, Indonesia

preprint OA: closed
Full text JSON View at publisher
Full text 55,349 characters · extracted from preprint-html · click to expand
Ethnobotanical Knowledge in the Primbon Padukunan Manuscripts: A Historical Ethnobotany from the Merapi–Merbabu Region, Indonesia | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Ethnobotanical Knowledge in the Primbon Padukunan Manuscripts: A Historical Ethnobotany from the Merapi–Merbabu Region, Indonesia Suyami Suyami, Sumarno Sumarno, Mumfangati Titi, Nurwanti Yustina Hastrini, and 10 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8501351/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Traditional medical knowledge preserved in manuscript sources represents an important yet underexplored domain within ethnobotanical research. The Primbon Padukunan, originating from the Merapi–Merbabu scriptorium, constitutes a significant textual repository documenting indigenous therapeutic knowledge that integrates material and immaterial healing practices within a culturally embedded medical system. Methods This study employs a manuscript-based ethnobotanical approach through close textual analysis of the Primbon Padukunan. Medicinal formulations, ingredients, therapeutic methods, and disease categories were systematically identified, classified, and quantified. Identifiable biological materials were analyzed taxonomically, while healing practices were categorized according to their reliance on tangible ( sakala ) and intangible components, including incantations (mantra) and talismanic diagrams ( rajah ). Diseases were further classified according to affected subject groups and etiological frameworks. Results The Primbon Padukunan documents 119 medicinal formulations that employ tangible ( sakala ) materials, including plants, animals, and other substances. A total of 126 medicinal ingredients are recorded, of which 109 are identifiable, comprising 105 plant species, two animal-derived materials, and two non-biological substances, namely water and salt. In addition to material-based therapies, 66 combined formulations integrate tangible components with immaterial elements in the form of incantations (mantra) and talismanic diagrams (rajah). Therapeutic practices relying exclusively on immaterial means include 27 treatments using incantations alone and 31 treatments using rajah alone. The manuscript records 84 types of illnesses affecting four subject clusters: adults, pregnant women, children, and general ailments. These illnesses encompass both naturalistic and personalistic conditions, including external, internal, and psychological disorders. Conclusions The Primbon Padukunan reveals a complex and integrative medical system in which ethnobotanical knowledge is embedded within broader cosmological and symbolic frameworks. The coexistence of material and immaterial therapies demonstrates that plants and other substances are not positioned merely as pharmacological agents, but as components of a holistic healing system. This study underscores the value of manuscript-based ethnobotany in reconstructing historical medical knowledge and contributes to broader discussions on the cultural dimensions of traditional medicine and the decolonization of ethnobotanical research. Ethnomedicine Medicinal Plants Mantra Rajah Primbon Padukunan Javanese Manuscripts Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8501351","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":573097122,"identity":"2ccfb367-28f7-4afe-91a9-970a8e5fc0a9","order_by":0,"name":"Suyami Suyami","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Suyami","middleName":"","lastName":"Suyami","suffix":""},{"id":573097123,"identity":"f8a680ca-4eb8-4ebf-873b-71910d7f617a","order_by":1,"name":"Sumarno Sumarno","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABF0lEQVRIiWNgGAWjYBCDBDaGBAYGxgYbOX4wt4B4LWnGkg0grgERWhggWg4lGhwA8fFokZ+Rnfi5codNHh978jOJnzsOJBifX5344YEBgzy/2AGsWgxu5G6WPHsmrZiN55mZZO+ZO3lmN95ulgA6zHDm7ATsWiRyN0g2th1ObJNIMJPgbXtWbHbj7AaQlgSD29i1yM/I3fwToiX9m+RfIGPzjLObf+DTwnAjdxvUlhwzaV4gYwN/7za8thicebvNsrEtLbGN502xtWxbmrHEDd5tFgkGEjj9It+eu/lmY5tN4vz29I0337YBo7L/7OabPyps5PmlcTgMCbBIgCkJsEoJgspBgPkDmOI/QJTqUTAKRsEoGDkAALiVaTBDWSzAAAAAAElFTkSuQmCC","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":true,"prefix":"","firstName":"Sumarno","middleName":"","lastName":"Sumarno","suffix":""},{"id":573097124,"identity":"52fbab90-ae4a-4720-9ef2-27cd7bd39f88","order_by":2,"name":"Mumfangati Titi","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Mumfangati","middleName":"","lastName":"Titi","suffix":""},{"id":573097125,"identity":"2d739ab7-1d4b-426e-8c38-2e8756d55a8d","order_by":3,"name":"Nurwanti Yustina Hastrini","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Nurwanti","middleName":"Yustina","lastName":"Hastrini","suffix":""},{"id":573097126,"identity":"f9769675-07d1-4177-a81f-64c0a69299b9","order_by":4,"name":"Agusta Rendra","email":"","orcid":"","institution":"Sraddha Institute","correspondingAuthor":false,"prefix":"","firstName":"Agusta","middleName":"","lastName":"Rendra","suffix":""},{"id":573097127,"identity":"b105333d-2483-4712-b3d6-faded82c3713","order_by":5,"name":"Rusnandar Nandang","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Rusnandar","middleName":"","lastName":"Nandang","suffix":""},{"id":573097128,"identity":"5db49ddf-b378-4621-a3d9-26c8a104bd85","order_by":6,"name":"Refisrul Refisrul","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Refisrul","middleName":"","lastName":"Refisrul","suffix":""},{"id":573097129,"identity":"6f239459-51c1-4898-a2d4-ef8f90567c22","order_by":7,"name":"Basori Basori","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Basori","middleName":"","lastName":"Basori","suffix":""},{"id":573097130,"identity":"8e1363ca-a661-4177-87b1-89bd229ac491","order_by":8,"name":"Herlinawati Lina","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Herlinawati","middleName":"","lastName":"Lina","suffix":""},{"id":573097131,"identity":"c38a042f-8405-42a0-b5d0-0746416eb52c","order_by":9,"name":"Djakaria Salmin","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Djakaria","middleName":"","lastName":"Salmin","suffix":""},{"id":573097132,"identity":"62be0bcf-b765-407e-9f28-8d7fd79115e2","order_by":10,"name":"Wahyono Tugas Tri","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Wahyono","middleName":"Tugas","lastName":"Tri","suffix":""},{"id":573097133,"identity":"15c90049-5592-4ea6-9333-912dc067480a","order_by":11,"name":"Rostiyati Ani","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Rostiyati","middleName":"","lastName":"Ani","suffix":""},{"id":573097134,"identity":"f650a58f-94aa-408a-b4cf-18c532c673e3","order_by":12,"name":"Sukari Sukari","email":"","orcid":"","institution":"National Research and Innovation Agency","correspondingAuthor":false,"prefix":"","firstName":"Sukari","middleName":"","lastName":"Sukari","suffix":""},{"id":573097140,"identity":"73c10fa6-3b73-4085-af36-adfd1536b537","order_by":13,"name":"Dewi Triyasinta Noor Laksmita","email":"","orcid":"","institution":"Gadjah Mada University","correspondingAuthor":false,"prefix":"","firstName":"Dewi","middleName":"Triyasinta Noor","lastName":"Laksmita","suffix":""}],"badges":[],"createdAt":"2026-01-02 13:53:23","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8501351/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8501351/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":100269507,"identity":"eb115517-dbe7-4da8-8a77-deccfd5cab0a","added_by":"auto","created_at":"2026-01-14 19:33:53","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":2514735,"visible":true,"origin":"","legend":"","description":"","filename":"TemplateJournalofEthnobiologyandEthnomedicine2026Revisi2.docx","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/d6f3911840f2d1f28c585e4f.docx"},{"id":100372727,"identity":"c3e747e1-c7f4-4e43-892e-43d83e781f77","added_by":"auto","created_at":"2026-01-16 08:13:03","extension":"json","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":15702,"visible":true,"origin":"","legend":"","description":"","filename":"bb174853599c4216af93bd9f8245dbf0.json","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/d993e228e4c678107c5d654e.json"},{"id":100269420,"identity":"df8412e1-cfb7-42c1-b5d2-6d574664f229","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"xml","order_by":2,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":144776,"visible":true,"origin":"","legend":"","description":"","filename":"bb174853599c4216af93bd9f8245dbf01enriched.xml","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/33523353a3cae126b4b319ff.xml"},{"id":100269416,"identity":"d326e5fb-4352-4dc3-8a8e-4f4309b29ca1","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":3,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/33e29e6a6bad3c05ddc88bcb.png"},{"id":100269414,"identity":"e8b793ee-a2dd-409a-ad34-dbd83b9819f4","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":4,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/d8b015e575b6e668bff4e2ec.png"},{"id":100372032,"identity":"aa1ed945-8d60-4901-bfd6-0879c57cca0b","added_by":"auto","created_at":"2026-01-16 08:11:26","extension":"png","order_by":5,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/6e9b6e19837802aa73eb53f1.png"},{"id":100372539,"identity":"9192917d-68cc-4f72-9732-8e79d71f268c","added_by":"auto","created_at":"2026-01-16 08:12:39","extension":"png","order_by":6,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/851358dded38e0721a9a7933.png"},{"id":100373077,"identity":"bb793cc9-fcb6-4984-b33c-b813a327180e","added_by":"auto","created_at":"2026-01-16 08:13:35","extension":"png","order_by":7,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9fc6b6866b77832d6257dadd.png"},{"id":100373298,"identity":"b97b8667-ed71-431e-bebd-e2313a493c05","added_by":"auto","created_at":"2026-01-16 08:14:01","extension":"png","order_by":8,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/70c5eb161efc8f5f1c2c4b38.png"},{"id":100371701,"identity":"97a09871-dcb7-44cf-bf8d-14de3d801902","added_by":"auto","created_at":"2026-01-16 08:10:43","extension":"png","order_by":9,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":6023,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage15.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/ce63ab919426dcd78a7dd4bf.png"},{"id":100372265,"identity":"a54da8fe-8822-437b-86ac-88fdef50fa78","added_by":"auto","created_at":"2026-01-16 08:11:54","extension":"png","order_by":10,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":17838,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage16.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/ada56db6daecff3db0957602.png"},{"id":100372804,"identity":"a2c9f9bc-b86d-4589-a35b-8d794006faee","added_by":"auto","created_at":"2026-01-16 08:13:12","extension":"jpeg","order_by":11,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":19058,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage17.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/3933801a1c0e7e7b5707ce04.jpeg"},{"id":100269425,"identity":"ee9f3c71-d567-470c-9546-f22c201a91eb","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"jpeg","order_by":12,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":2041,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage18.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/a4a9837f7f45c11d63b82fc3.jpeg"},{"id":100373062,"identity":"7ff5433d-78e8-4a74-b668-ddf8e17aadc9","added_by":"auto","created_at":"2026-01-16 08:13:34","extension":"jpeg","order_by":13,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":27496,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage19.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/db4bf890b8bd5737fb6b66de.jpeg"},{"id":100372459,"identity":"50378631-5a88-4a13-9633-9881b1cb9795","added_by":"auto","created_at":"2026-01-16 08:12:26","extension":"png","order_by":14,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/3545d8c5dec014834ceafbe3.png"},{"id":100269423,"identity":"7466d025-dc7d-49f8-92ba-dbb63933f0ab","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":15,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":91707,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage20.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/27fc611d0eb985075c5baca9.png"},{"id":100372863,"identity":"92f8315f-a07f-4a5e-b1a2-cce57b05fb5a","added_by":"auto","created_at":"2026-01-16 08:13:18","extension":"png","order_by":16,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":78146,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage21.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9581ccb126f99dce6d3ca10c.png"},{"id":100269428,"identity":"09a47405-388a-4a10-b158-90c83bbdddde","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":17,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":151898,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage22.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/fe66e1fac7559631995ccaec.png"},{"id":100269431,"identity":"f98f4262-83a1-464a-b5ad-133ee0e33c94","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":18,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":72272,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage23.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/bd4d327f13bca2ad94974325.png"},{"id":100269427,"identity":"02c48465-2b96-42b8-ad98-f6aabae1f06c","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":19,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":79722,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage24.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9b1a205c639c4ed697dbad74.png"},{"id":100269451,"identity":"9384c5d9-895b-4c07-ad65-0e8e4234689b","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"jpeg","order_by":20,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":3961,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage25.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/fb05696eb2b3b14fafdf0619.jpeg"},{"id":100269429,"identity":"01bced31-50bf-44fe-a546-6ff9f57b80db","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":21,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":186849,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage26.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9861c1186968aaf02b3fd4d3.png"},{"id":100372972,"identity":"3fe4a451-861e-4171-abe2-3fb167435356","added_by":"auto","created_at":"2026-01-16 08:13:29","extension":"png","order_by":22,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":128017,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage27.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/35f97c08514ea287fc488384.png"},{"id":100373034,"identity":"c3ee4d46-5b76-4396-8d15-edcf07a4294d","added_by":"auto","created_at":"2026-01-16 08:13:32","extension":"png","order_by":23,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":77407,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage28.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/32ed840959b6925ae7f5e977.png"},{"id":100269438,"identity":"59daf118-9d22-4fbf-8f59-55013615bbee","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":24,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":165340,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage29.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/023cd0d5e9ab282cc6fb4cfb.png"},{"id":100269449,"identity":"0b542d18-f1df-4093-b6a4-a8e188549bd2","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":25,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/1630a27629d3dc5faba5c992.png"},{"id":100372864,"identity":"8f5b9933-3017-4336-89df-93e22a78b98e","added_by":"auto","created_at":"2026-01-16 08:13:18","extension":"png","order_by":26,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":207546,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage30.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9f871c3f2494b9bd75df6cd4.png"},{"id":100372271,"identity":"6e16db32-4304-4f25-811c-d15d7c42cf92","added_by":"auto","created_at":"2026-01-16 08:11:54","extension":"png","order_by":27,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":151566,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage31.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/1e9208bf852808a6ba06ba8a.png"},{"id":100371847,"identity":"224c85f1-2f47-4b4d-9a59-2a582596f065","added_by":"auto","created_at":"2026-01-16 08:11:06","extension":"png","order_by":28,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":195458,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage32.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/52fc3c16f5c8b0c0b738e1f5.png"},{"id":100372895,"identity":"1734f360-4467-4b9c-8577-11d2a7859bd6","added_by":"auto","created_at":"2026-01-16 08:13:23","extension":"png","order_by":29,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":170882,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage33.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/a8e7d6aa2d72437acff036da.png"},{"id":100269463,"identity":"1c4b040f-0f32-41cd-b1d2-6dbaf2851d35","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":30,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":61022,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage34.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/67a9090f76caf33104cc1920.png"},{"id":100371585,"identity":"9196ddf0-0918-4f39-bd69-09d4ab5b3f3e","added_by":"auto","created_at":"2026-01-16 08:10:34","extension":"png","order_by":31,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":116453,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage35.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/fd976c760e1f9d318baf3930.png"},{"id":100372560,"identity":"5a1dc042-409c-4889-904a-c69853e4e478","added_by":"auto","created_at":"2026-01-16 08:12:40","extension":"png","order_by":32,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":86143,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage36.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/f534d1c50e3025d762511192.png"},{"id":100269470,"identity":"96adee99-5281-4bcb-8346-73c514e2bbd9","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":33,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":186849,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage26.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/6725b3129a3ea035c73fc997.png"},{"id":100269445,"identity":"2ba12b28-e979-4baa-8821-0146b8ccf008","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":34,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":128017,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage27.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/09adbb4681205bf8afa9a1b4.png"},{"id":100373293,"identity":"9074618e-9003-4187-8c4b-03f2da602245","added_by":"auto","created_at":"2026-01-16 08:14:01","extension":"png","order_by":35,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":77407,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage28.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/4c49e095be258855d0e48f00.png"},{"id":100269435,"identity":"25b8cd93-4ac9-4a4b-a43e-04ecc6207a4d","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":36,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/b2b5d30fd2a4833f6e23f39e.png"},{"id":100269459,"identity":"2f478aae-b4c8-435c-be74-f5ae88a5840f","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":37,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":90967,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage40.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/406d3a70e921d742f84c5f3e.png"},{"id":100372914,"identity":"7bece9c0-a55f-4f15-9502-30ab6352d321","added_by":"auto","created_at":"2026-01-16 08:13:24","extension":"png","order_by":38,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":90504,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage41.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/b9cae5e5737ffaa849efe66d.png"},{"id":100372362,"identity":"2ba51efb-a367-4346-bc45-5f19a9572863","added_by":"auto","created_at":"2026-01-16 08:12:08","extension":"png","order_by":39,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":39955,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage42.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/a6f6e6e2154656bdf5df6987.png"},{"id":100269454,"identity":"79464332-2b6a-4d5d-94e2-4fc70930f1ea","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":40,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":68873,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage43.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/949faaa3b30aff15781696cf.png"},{"id":100371258,"identity":"43fa236e-52fa-413b-9d3a-71bc2a3ab2c2","added_by":"auto","created_at":"2026-01-16 08:09:44","extension":"jpeg","order_by":41,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":17975,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage44.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/fb2deeab94e88f4ca8a2bdbd.jpeg"},{"id":100372013,"identity":"19bf7f5f-156f-4a43-9eac-d91e734d12cf","added_by":"auto","created_at":"2026-01-16 08:11:23","extension":"png","order_by":42,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/d3ee090e8a423bdaa4774bff.png"},{"id":100373155,"identity":"ed660aac-58f8-41bd-ac45-03055d1388da","added_by":"auto","created_at":"2026-01-16 08:13:45","extension":"png","order_by":43,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/11bb933a7397f0a0ec129941.png"},{"id":100269433,"identity":"8fba301b-8359-49c4-8e3a-572dff6d7eb0","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":44,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/093e2090496cddd4d48bcb3e.png"},{"id":100269436,"identity":"cf660d4a-8347-4a51-a931-47bc0c904b50","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":45,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/12f06446b250f52461c4bb80.png"},{"id":100269434,"identity":"8611b6b0-54e2-4adb-9032-fee2d163b969","added_by":"auto","created_at":"2026-01-14 19:33:38","extension":"png","order_by":46,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":835,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/b1f0c87cf5b2f30f4aed2db3.png"},{"id":100269455,"identity":"44c35820-2030-4c06-b5d4-ca006eb9d447","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":47,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/a29cb4efaaed516ab5754ede.png"},{"id":100269444,"identity":"8638a5a4-7a61-4574-9728-d5dd16c455cc","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":48,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/2a34e3ace489d2229afeaf73.png"},{"id":100269458,"identity":"9e0adf5f-7d73-4162-9c73-bb74435d3e59","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":49,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/5bb40645e51918e70d618b6d.png"},{"id":100269482,"identity":"0ca6d997-920e-48fd-9e04-57bd965b43cb","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":50,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/f4a7b31cb8161bd600d8b9ec.png"},{"id":100371416,"identity":"5048aa1e-2609-4fc2-baef-87edf28892fd","added_by":"auto","created_at":"2026-01-16 08:10:04","extension":"png","order_by":51,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/2fc5d8665d8c77082322b26d.png"},{"id":100371756,"identity":"75d24d5f-2841-432d-83d2-9c2afca0bc2d","added_by":"auto","created_at":"2026-01-16 08:10:51","extension":"png","order_by":52,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/618b449948fea492afd0e059.png"},{"id":100372958,"identity":"e98c59be-6c2e-4706-9ec5-725dc6a96942","added_by":"auto","created_at":"2026-01-16 08:13:27","extension":"png","order_by":53,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":2439,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage15.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/bb20ac3ce925ef789e37c8f9.png"},{"id":100371684,"identity":"5781f3b3-eafb-4d61-b88f-84cb4669830b","added_by":"auto","created_at":"2026-01-16 08:10:42","extension":"png","order_by":54,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":6520,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage16.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/aa082e66b0bd9bb5bccc9958.png"},{"id":100372613,"identity":"44d885fa-42bb-42f5-b9bf-6b47f552afeb","added_by":"auto","created_at":"2026-01-16 08:12:46","extension":"png","order_by":55,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":29432,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage17.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/8c903881ad397280ab230831.png"},{"id":100269487,"identity":"f9143068-0bcd-4943-bd1d-70d00c3f3099","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":56,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":2869,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage18.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/1949df537724dff76eff5ee7.png"},{"id":100373079,"identity":"f7b25621-77a6-4667-bd45-bc66654afcdc","added_by":"auto","created_at":"2026-01-16 08:13:35","extension":"png","order_by":57,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":47757,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage19.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/fa65ecb5f12939e1aef4d020.png"},{"id":100269450,"identity":"3809bbfb-0938-4b0a-b056-ecfb6ca7b80e","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":58,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/04c2fb12e8bf7f912010781e.png"},{"id":100269491,"identity":"6f356b3e-fb4d-4f4a-8b1e-4d658836434d","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":59,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":31052,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage20.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/1720b889c40101c7d6578912.png"},{"id":100269439,"identity":"25b8d418-efb5-4a0c-88ce-4050f9d1b205","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":60,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":25002,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage21.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/59caf7138cf8972abf253c10.png"},{"id":100269489,"identity":"79e66bc5-f602-463f-baf1-a86d6d4f4940","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":61,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":51828,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage22.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/ea6059273461b032e8b0fbe9.png"},{"id":100372405,"identity":"fe77e65a-9942-461f-b42f-eade696c8d55","added_by":"auto","created_at":"2026-01-16 08:12:16","extension":"png","order_by":62,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":26053,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage23.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/46efbcd344a77d4158478540.png"},{"id":100269485,"identity":"57bcb89d-217d-41fd-a3a7-829c2058a138","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":63,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":25173,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage24.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/5a3d8643e628316156363765.png"},{"id":100269492,"identity":"f70f9b2f-82e3-433a-8225-3e6e9b1016a2","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":64,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":6399,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage25.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/2b3d305260a11e08ed06764a.png"},{"id":100269483,"identity":"1f9591c4-ebc1-44b2-9a5f-91d8195aa025","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":65,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":52350,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage26.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/5743ffe822c10862ac779f9a.png"},{"id":100269473,"identity":"4bcaccd2-53e7-408c-8700-82c230aa904d","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":66,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":37940,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage27.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/45433381ed92522ff190d23a.png"},{"id":100269447,"identity":"849bf11f-4d77-4a53-8a07-1f2bbd6213d3","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":67,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":24064,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage28.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/ac925dae494a1b495ccd0b0b.png"},{"id":100371374,"identity":"66cefcf8-2245-46b7-b359-028350271bb4","added_by":"auto","created_at":"2026-01-16 08:09:57","extension":"png","order_by":68,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":50659,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage29.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/823b3287f40db54e51f45abb.png"},{"id":100372782,"identity":"75229105-efc5-471f-8e7a-cf9bec9af7d9","added_by":"auto","created_at":"2026-01-16 08:13:11","extension":"png","order_by":69,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/2db0d0c604a1a575cc6a4bbe.png"},{"id":100269466,"identity":"48abf35d-2ac6-4bca-992d-ee93da846ab5","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":70,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":65690,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage30.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/ab84a4fb83f64bb29ef7fa97.png"},{"id":100269471,"identity":"ee567e77-06bb-49c5-b0bf-d8998a0ae569","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":71,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":45430,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage31.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/f34813be5d00806163824cad.png"},{"id":100373056,"identity":"50897eb5-05fd-4bae-bc1f-c3cae834243c","added_by":"auto","created_at":"2026-01-16 08:13:33","extension":"png","order_by":72,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":55011,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage32.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/f7dcac3027ba5565676b62a7.png"},{"id":100372965,"identity":"4d83985e-9e41-4422-ad85-c6a62a18e994","added_by":"auto","created_at":"2026-01-16 08:13:28","extension":"png","order_by":73,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":51074,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage33.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/073e21c1095ea37093f63156.png"},{"id":100269453,"identity":"3d218a8c-6000-429b-b785-8bffabfefd2f","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":74,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":19586,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage34.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/5462823727718d972383a5de.png"},{"id":100373096,"identity":"36ce07ed-019e-4623-a64c-4fa32a3ca170","added_by":"auto","created_at":"2026-01-16 08:13:37","extension":"png","order_by":75,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":23965,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage35.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/bb56e77884e643047fb7707f.png"},{"id":100269496,"identity":"efb39fdc-c431-454c-a8b7-41b776777a36","added_by":"auto","created_at":"2026-01-14 19:33:41","extension":"png","order_by":76,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":24470,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage36.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9aaeb7445d8617b128c94808.png"},{"id":100371259,"identity":"4f1934eb-42c2-4dc3-aee4-7669c96c7267","added_by":"auto","created_at":"2026-01-16 08:09:44","extension":"png","order_by":77,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":52350,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage26.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/5e2d06337a4f311cfff087ab.png"},{"id":100372332,"identity":"8ff36314-6e9e-4feb-952c-e4b99ae9813f","added_by":"auto","created_at":"2026-01-16 08:12:03","extension":"png","order_by":78,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":37940,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage27.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/6aff5298a8b078b8eabdf604.png"},{"id":100269461,"identity":"d155ca40-17db-43ac-90f0-76fe11793988","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":79,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":24064,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage28.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/45685917314864065f32106c.png"},{"id":100373016,"identity":"f6b28f5a-f241-4b93-9ca8-c194d6aa07fc","added_by":"auto","created_at":"2026-01-16 08:13:31","extension":"png","order_by":80,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9e838ba1fdd90b4368a3c061.png"},{"id":100269500,"identity":"b1b9276f-9431-4c69-bf43-e0ccc1209529","added_by":"auto","created_at":"2026-01-14 19:33:41","extension":"png","order_by":81,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":30982,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage40.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/a72813e3a2c413945a5538ae.png"},{"id":100269460,"identity":"4df34e6e-66bd-430c-9c2c-a1de539c69f3","added_by":"auto","created_at":"2026-01-14 19:33:39","extension":"png","order_by":82,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":33675,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage41.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/e0c4dda4a9771e681ba2a7fa.png"},{"id":100372051,"identity":"6899b60d-148b-49e3-9285-6f9a9ad99c82","added_by":"auto","created_at":"2026-01-16 08:11:29","extension":"png","order_by":83,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":12584,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage42.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/f7f17d7715184889715a72f0.png"},{"id":100372569,"identity":"78e67898-f792-415c-881a-91fe52bbffb1","added_by":"auto","created_at":"2026-01-16 08:12:41","extension":"png","order_by":84,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":21265,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage43.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/8a9c45a22ddacd6ce16dfb6d.png"},{"id":100372590,"identity":"040af42c-e19b-4c33-a247-3f8691b1363d","added_by":"auto","created_at":"2026-01-16 08:12:43","extension":"png","order_by":85,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":30809,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage44.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/b9ad171848f0a17182690aad.png"},{"id":100269478,"identity":"f7cb81c2-a60b-4a69-8b76-947803adb7a3","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":86,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/5f2d813d1e6679cc487b8055.png"},{"id":100373133,"identity":"11f6a2b5-ad19-4fba-89ca-974dcdb91ff4","added_by":"auto","created_at":"2026-01-16 08:13:42","extension":"png","order_by":87,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/f278c2b4270ce76fc48ed919.png"},{"id":100269498,"identity":"a9c5817e-c2c7-4352-94b2-43bc9b0d02dd","added_by":"auto","created_at":"2026-01-14 19:33:41","extension":"png","order_by":88,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/9cd5086a26a8a473f2f9dfad.png"},{"id":100269469,"identity":"62ea3b57-46a4-4981-ab5d-f90e222607f9","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":89,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/92393704042dda0d3da82abb.png"},{"id":100269479,"identity":"862ab2ae-9b2b-4792-bddc-bacde9eaf7ea","added_by":"auto","created_at":"2026-01-14 19:33:40","extension":"png","order_by":90,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":702,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/64618f9385abcf9d3c11a9ec.png"},{"id":100269504,"identity":"84fb66d7-f331-45f4-963d-e47ef16a100b","added_by":"auto","created_at":"2026-01-14 19:33:41","extension":"xml","order_by":91,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":143259,"visible":true,"origin":"","legend":"","description":"","filename":"bb174853599c4216af93bd9f8245dbf01structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/8006691d20a09cef545b173b.xml"},{"id":100373120,"identity":"b043bc31-2045-4b1e-97f5-6f77f728bab7","added_by":"auto","created_at":"2026-01-16 08:13:40","extension":"html","order_by":92,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":155941,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1/961d8805080b5fa695b411e6.html"},{"id":101548974,"identity":"3fce43c8-0bf1-4405-95a0-121764bd15a5","added_by":"auto","created_at":"2026-01-31 06:40:17","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":844306,"visible":true,"origin":"","legend":"","description":"","filename":"TemplateJournalofEthnobiologyandEthnomedicine2026Revisi2.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8501351/v1_covered_de3cfee6-0f03-4b55-960d-8150e12818e2.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Ethnobotanical Knowledge in the Primbon Padukunan Manuscripts: A Historical Ethnobotany from the Merapi–Merbabu Region, Indonesia","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Ethnomedicine, Medicinal Plants, Mantra, Rajah, Primbon Padukunan, Javanese Manuscripts","lastPublishedDoi":"10.21203/rs.3.rs-8501351/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8501351/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eTraditional medical knowledge preserved in manuscript sources represents an important yet underexplored domain within ethnobotanical research. The Primbon Padukunan, originating from the Merapi\u0026ndash;Merbabu scriptorium, constitutes a significant textual repository documenting indigenous therapeutic knowledge that integrates material and immaterial healing practices within a culturally embedded medical system.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eThis study employs a manuscript-based ethnobotanical approach through close textual analysis of the Primbon Padukunan. Medicinal formulations, ingredients, therapeutic methods, and disease categories were systematically identified, classified, and quantified. Identifiable biological materials were analyzed taxonomically, while healing practices were categorized according to their reliance on tangible (\u003cem\u003esakala\u003c/em\u003e) and intangible components, including incantations (mantra) and talismanic diagrams (\u003cem\u003erajah\u003c/em\u003e). Diseases were further classified according to affected subject groups and etiological frameworks.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThe Primbon Padukunan documents 119 medicinal formulations that employ tangible (\u003cem\u003esakala\u003c/em\u003e) materials, including plants, animals, and other substances. A total of 126 medicinal ingredients are recorded, of which 109 are identifiable, comprising 105 plant species, two animal-derived materials, and two non-biological substances, namely water and salt. In addition to material-based therapies, 66 combined formulations integrate tangible components with immaterial elements in the form of incantations (mantra) and talismanic diagrams (rajah). Therapeutic practices relying exclusively on immaterial means include 27 treatments using incantations alone and 31 treatments using \u003cem\u003erajah\u003c/em\u003e alone. The manuscript records 84 types of illnesses affecting four subject clusters: adults, pregnant women, children, and general ailments. These illnesses encompass both naturalistic and personalistic conditions, including external, internal, and psychological disorders.\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eThe Primbon Padukunan reveals a complex and integrative medical system in which ethnobotanical knowledge is embedded within broader cosmological and symbolic frameworks. The coexistence of material and immaterial therapies demonstrates that plants and other substances are not positioned merely as pharmacological agents, but as components of a holistic healing system. This study underscores the value of manuscript-based ethnobotany in reconstructing historical medical knowledge and contributes to broader discussions on the cultural dimensions of traditional medicine and the decolonization of ethnobotanical research.\u003c/p\u003e","manuscriptTitle":"Ethnobotanical Knowledge in the Primbon Padukunan Manuscripts: A Historical Ethnobotany from the Merapi–Merbabu Region, Indonesia","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-14 19:33:33","doi":"10.21203/rs.3.rs-8501351/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"cb032418-474a-478d-9f4b-56f64e1bac99","owner":[],"postedDate":"January 14th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-01-31T06:39:39+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-14 19:33:33","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8501351","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8501351","identity":"rs-8501351","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2026) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00