A Study on Cytokines In Severe and Non-severe Malaria in a Tertiary Care Hospital in Odisha.

A Study on Cytokines In Severe and Non-severe Malaria in a Tertiary Care Hospital in Odisha. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A Study on Cytokines In Severe and Non-severe Malaria in a Tertiary Care Hospital in Odisha. Madhusmita Patnaik, Gautam Patnaik, Ashok kumar Sarangi, Alok Ranjan Nayak, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4563289/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Odisha state, one of the leading contributors to the malaria burden in India as it accounted for around 27% of India’s malaria cases having 17.6% of all reported deaths. It has been seen that the cytokines, both pro-inflammatory and anti-inflammatory can be taken as the markers for both complication or severity of Malaria. Hence our study is essentially meant to study cytokines in both vivax and falciparum of malaria in our area. Methods: Haematological parameters like Haemoglobin, Platelet count and other hematocrit was accessed. From serum part biochemical tests like Liver function test, Blood sugar levels, Kidney function test and Glucose 6- Phosphate dehydrogenase (G6PD) was done. From the serum cytokines study particularly pro and anti-Inflammatory cytokines were done involved in Malaria. Results: Out of 39 cases9 were severe and 30 nonsevere malaria.The mean age of cases in severe malaria was 42.72 ± 17.14 years and 36.17 ±14.07 years in nonsevere malaria.IL1b levels were higher in both vivax and falciparum malaria.IL-4 levels are lower in non-severe malaria compared to severe group.. IL-6, IL-7 levels in non-severe and severe groups, IL-8 levels were very high in falciparum and IL-9 levels were lower in malaria cases whereas IL-10 , TNF-alpha levels were higher. Conclusion: IL-8 and IL-1b both can be taken as marker in severe malaria infection. As it is often difficult to assess the progression and severity of malaria in the early stages, these arrays of cytokines can be useful in diagnostic as well as prognostic purpose. Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4563289","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":313573200,"identity":"18744ac1-539d-4c07-a30d-26dd9444fece","order_by":0,"name":"Madhusmita Patnaik","email":"","orcid":"","institution":"SLN Medical College and Hospital: Saheed Laxman Nayak Medical College and Hospital","correspondingAuthor":false,"prefix":"","firstName":"Madhusmita","middleName":"","lastName":"Patnaik","suffix":""},{"id":313573201,"identity":"9c0d460b-b4ee-40c5-8fb9-cb46c400d576","order_by":1,"name":"Gautam Patnaik","email":"","orcid":"","institution":"District General Hospital","correspondingAuthor":false,"prefix":"","firstName":"Gautam","middleName":"","lastName":"Patnaik","suffix":""},{"id":313573202,"identity":"02e84285-4d2b-41da-816c-5d3fe2034692","order_by":2,"name":"Ashok kumar Sarangi","email":"","orcid":"","institution":"Trident Academy of Creative Technology","correspondingAuthor":false,"prefix":"","firstName":"Ashok","middleName":"kumar","lastName":"Sarangi","suffix":""},{"id":313573203,"identity":"f73e2ab1-60c7-45ee-8b6a-37e1fcc7919e","order_by":3,"name":"Alok Ranjan Nayak","email":"","orcid":"","institution":"Trident Academy of Creative Technology","correspondingAuthor":false,"prefix":"","firstName":"Alok","middleName":"Ranjan","lastName":"Nayak","suffix":""},{"id":313573204,"identity":"9f1dc28b-8cec-4f46-8bce-88f10d290561","order_by":4,"name":"Anshuman Sarangi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA9UlEQVRIiWNgGAWjYHACNjBpIAEkPlQACWbmBuK1MM44A9LCSIIWZt42EJOAFv7Z7c8e8+bY5ZlLtz/7wDuvNpq/HajlR8U2nFok7pwxN+bdllxsOeeM8QzJbcdzZxxmbGDsOXMbtzU3ctikebcxJ264kcPMYLjtWG4DUAszYxtuLfI30p8BtdQDtaQ/Zkiccyx3PiEtBjcSzIBaDgO1JBgzHGyoyd1ASIvhjRwzybnbjifuBPqFseHYgdyNQC0H8flFDugwibfbqhO3S7c/Zv5TU5c77/zhgw9+VODxPho4DCYPEK0eCOpIUTwKRsEoGAUjBAAAFkdegpQbMcIAAAAASUVORK5CYII=","orcid":"","institution":"Trident Academy of Creative Technology","correspondingAuthor":true,"prefix":"","firstName":"Anshuman","middleName":"","lastName":"Sarangi","suffix":""}],"badges":[],"createdAt":"2024-06-11 10:14:00","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4563289/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4563289/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":63679136,"identity":"2eadd502-5eca-46c9-a77a-ce0d5ded59b4","added_by":"auto","created_at":"2024-08-31 05:42:04","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":784892,"visible":true,"origin":"","legend":"","description":"","filename":"AStudyonCytokinesInSevereandNon.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4563289/v1_covered_dcb1038c-1ca0-4edc-ac75-2bdf2aa52b42.pdf"}],"financialInterests":"","formattedTitle":"A Study on Cytokines In Severe and Non-severe Malaria in a Tertiary Care Hospital in Odisha.","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4563289/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4563289/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground: \u0026nbsp;Odisha state, one of the leading contributors to the malaria burden in India as it accounted for around 27% of India’s malaria cases having 17.6% of all reported deaths. It has been seen that the cytokines, both pro-inflammatory and anti-inflammatory can be taken as the markers for both complication or severity of Malaria. Hence our study is essentially meant to study cytokines in both vivax and falciparum of malaria in our area.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMethods: Haematological parameters like Haemoglobin, Platelet count and other hematocrit was accessed. From serum part biochemical tests like Liver function test, Blood sugar levels, Kidney function test and Glucose 6- Phosphate dehydrogenase (G6PD) was done. From the serum cytokines study particularly pro and anti-Inflammatory cytokines were done involved in Malaria.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eResults: Out of 39 cases9 were severe and 30 nonsevere malaria.The mean age of cases in severe malaria was 42.72 ± 17.14 years and 36.17 ±14.07 years in nonsevere malaria.IL1b levels were higher in both vivax and falciparum malaria.IL-4 levels are lower in non-severe malaria compared to severe group.. IL-6, IL-7 levels in non-severe and severe groups, IL-8 levels were very high in falciparum and IL-9 levels were lower in malaria cases whereas IL-10 , TNF-alpha levels were higher.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConclusion: IL-8 and IL-1b both can be taken as marker in severe malaria infection. As it is often difficult to assess the progression and severity of malaria in the early stages, these arrays of cytokines can be useful in diagnostic as well as prognostic purpose.\u003c/p\u003e","manuscriptTitle":"A Study on Cytokines In Severe and Non-severe Malaria in a Tertiary Care Hospital in Odisha.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-27 18:05:05","doi":"10.21203/rs.3.rs-4563289/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"1528e8f0-ce59-46ca-ab91-7d05296cc59d","owner":[],"postedDate":"June 27th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-08-31T05:33:56+00:00","versionOfRecord":[],"versionCreatedAt":"2024-06-27 18:05:05","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4563289","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4563289","identity":"rs-4563289","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}