Immune Dysregulation in Recurrent Dermatological Viral Afflictions: A Focus on Th17/Treg Axis Imbalance

Immune Dysregulation in Recurrent Dermatological Viral Afflictions: A Focus on Th17/Treg Axis Imbalance | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Immune Dysregulation in Recurrent Dermatological Viral Afflictions: A Focus on Th17/Treg Axis Imbalance Latha This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8411776/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This paper investigates the immunological underpinnings of a prevalent recurrent dermatological condition, characterized by frequent cutaneous outbreaks. While the precise pathogenesis remains elusive, this clinical experimental research aims to elucidate the role of specific immune cell subsets and associated cytokines. Peripheral blood samples were analyzed to assess the balance between regulatory T cells (Treg) and T helper 17 (Th17) cells, pivotal for maintaining immune homeostasis. Our findings reveal a significant alteration in the Th17/Treg balance in affected individuals compared to healthy controls, alongside notable changes in key inflammatory and regulatory cytokine profiles. This paper posits that such immune dysregulation is an important determinant in the occurrence, development, and resolution of this common skin disorder, offering critical insights into its underlying immunological mechanisms. Immunology Recurrent dermatological disorder immune dysregulation Th17/Treg balance regulatory T cells T helper 17 cells cytokine profiling cutaneous inflammation immunopathogenesis Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8411776","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":563374272,"identity":"6cb1cae3-7efd-44d0-8ad0-08fc379f7449","order_by":0,"name":"Latha","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABEElEQVRIiWNgGAWjYBACPgYGNgaGAxJAJvOBAx//2AAZjI0H8GlhY2CGaWFLfDizIQ2kpYEYLSAmj7Exb8NhsCh+Leznjz34ccYin392g5kE747zdmvbDwNtqbGJxqmFJ5ndsOeGhOWMOwfSJCTP3E7ediYRqOVYWm4DTocls0nwfJAwYLiRcEzCgO12stkBoBbGhsO4tfA/ZpP8A9QifyOxTSKB7Vyy2fmHBLRIJLNJ89yQMDC4kcxscLDtgJ3ZDUK2SDw2k5Y5I2FgeCON8WHDmeQEsxtAWxLw+IWfP/GZ5JtjdQZyN/I/HP5TYWdvdj794YMPNTY4tWCARLDKBGKVg4A9KYpHwSgYBaNgZAAA1dJkn5IrZz4AAAAASUVORK5CYII=","orcid":"","institution":"Vydehi Institute of Medical Sciences and Research Centre","correspondingAuthor":true,"prefix":"","firstName":"","middleName":"","lastName":"Latha","suffix":""}],"badges":[],"createdAt":"2025-12-20 11:20:36","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-8411776/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8411776/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":98846196,"identity":"bdd3333e-9234-40ac-8d3d-c497554a08e8","added_by":"auto","created_at":"2025-12-23 04:33:37","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":170655,"visible":true,"origin":"","legend":"","description":"","filename":"ImmuneDysregulationinRecurrentDermatologicalViralAfflictionsAFocusonTh17TregAxisImbalance13.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8411776/v1_covered_8b1f6594-5dbb-4818-91f7-cbc1559e4635.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003eImmune Dysregulation in Recurrent Dermatological Viral Afflictions: A Focus on Th17/Treg Axis Imbalance\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Independent Researcher","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Recurrent dermatological disorder, immune dysregulation, Th17/Treg balance, regulatory T cells, T helper 17 cells, cytokine profiling, cutaneous inflammation, immunopathogenesis","lastPublishedDoi":"10.21203/rs.3.rs-8411776/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8411776/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThis paper investigates the immunological underpinnings of a prevalent recurrent dermatological condition, characterized by frequent cutaneous outbreaks. 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