Association between Endometriosis and Vascular Endothelial Injury

Objective To explore the association between plasma asymmetric dimethylarginine(ADMA) and inflammation and endothelial injury in women with endometriosis.Methods The plasma levels of high sensitive-C reactive protein(hs-CRP),interleukin-6(IL-6),interleukin-8(IL-8),ADMA and brachial artery flow-mediated vasodilation(FMD) were measured in 40 patients with endometriosis and 30 women without endometriosis.The results were compared between the two groups.Results Plasma levels of hs-CRP,IL-6,IL-8,ADMA were significantly higher in women with endometriosis than those without endometriosis(P0.05).FMD was significantly lower in women with endometriosis(P0.05).FMD was negatively correlated with plasma levels of ADMA and hs-CRP.Conclusion The increased plasma ADMA levels and enhanced inflammatory factors are associated with impaired endothelial function in women with endometriosis.