From Stimulants to Stressors: Chemical Modulation of Development, Physiology, and Behavior in Drosophila melanogaster

From Stimulants to Stressors: Chemical Modulation of Development, Physiology, and Behavior in Drosophila melanogaster | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 9 February 2026 V1 Latest version Share on From Stimulants to Stressors: Chemical Modulation of Development, Physiology, and Behavior in Drosophila melanogaster Authors : Mitali Singhal , Sabita shaha 0009-0009-3815-0569 [email protected] , and Maria Katsikogianni Authors Info & Affiliations https://doi.org/10.22541/au.177063513.34291013/v1 109 views 57 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Drosophila melanogaster continues to be a tractable and genetically versatile model for dissecting the complex interplay between chemical exposures and biological systems. In this review, we examine how a broad spectrum of chemical agents---including psychoactive compounds, metabolic disruptors, endocrine modulators, and other bioactive xenobiotics---modulate developmental trajectories, neurophysiological functions, and behavioral phenotypes in Drosophila. We synthesize findings from studies employing transcriptomic, proteomic, genetic, and functional approaches to highlight conserved molecular pathways affected by compounds such as caffeine, ethanol, bisphenols, organophosphates, and emerging contaminants. Particular attention is given to chemical-induced alterations in neurodevelopment, synaptic connectivity, circadian regulation, mitochondrial function, oxidative stress responses, and reproductive fitness. Collectively, the evidence underscores the growing relevance of Drosophila in translational chemical biology, especially for high-throughput functional screening and systems-level toxicological investigations. These insights enhance our understanding of chemically induced perturbations at the organismal level and position Drosophila melanogaster as a powerful proxy for probing conserved, human-relevant toxicodynamic mechanisms. Supplementary Material File (m drosophila.docx) Download 6.34 MB Information & Authors Information Version history V1 Version 1 09 February 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords ecosystem ecosystem function method development molecular evolution Authors Affiliations Mitali Singhal Oxford College of Science View all articles by this author Sabita shaha 0009-0009-3815-0569 [email protected] General Hospital, Bangladesh View all articles by this author Maria Katsikogianni University of Bradford View all articles by this author Metrics & Citations Metrics Article Usage 109 views 57 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Mitali Singhal, Sabita shaha, Maria Katsikogianni. From Stimulants to Stressors: Chemical Modulation of Development, Physiology, and Behavior in Drosophila melanogaster. Authorea . 09 February 2026. DOI: https://doi.org/10.22541/au.177063513.34291013/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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