Preface

This paper is a preface/editorial for a Seminars in Reproductive Medicine issue focused on endometriosis-associated subfertility, outlining what readers will find across multiple invited reviews. It summarizes major themes and high-level approaches, including evidence linking adenomyosis with subfertility, endometrial alterations affecting implantation, animal model evidence, the role and trade-offs of surgery, and how endometriosis influences ovarian reserve, superovulation, IVF outcomes, endometrioma management, and pregnancy outcomes. The author notes that fertility decisions are complicated by conflicting studies and the scarcity of rigorous well-designed clinical trials, which limits definitive conclusions. This paper is centrally about endometriosis — it frames an evidence-focused collection of reviews on endometriosis and its consequences for fertility and pregnancy, while also introducing an adenomyosis subtopic.

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