Ultrasound-Guided Diagnosis and Treatment of Postsurgical Peripheral Nerve Entrapment in Persistent Pelvic Pain

A 34-year-old woman developed chronic pelvic and inguinal pain after liposculpture and abdominoplasty that persisted for approximately 10 months despite conservative management. Prior workup included CT and MRI, and venous Doppler ultrasound studies demonstrated pelvic varices and endometriosis. At an outside institution, the patient underwent pelvic variceal embolization without symptomatic improvement. Approximately seven months later, she underwent surgery for endometriosis, including hysterectomy, which also failed to relieve her symptoms. The patient was reassessed three months later in our institution, and her symptoms were characterized by burning and electric shock-like pain associated with tactile allodynia and hyperalgesia. The patient rated her baseline pain as 7/10 on the numeric rating scale (NRS), with worsening during ambulation [ 6 ]. Physical examination demonstrated a focal positive Tinel sign over the right-sided inguinal surgical scar within the topography of the genitofemoral nerve, inferior to the inguinal ligament. The femoral branch was expected to be lateral to the femoral artery in the femoral triangle, whereas the genital branch followed the inguinal canal toward the labial region (Figure 1 ). Based on a DN4 score consistent with neuropathic pain, the patient’s symptoms were classified as neuropathic rather than somatic [ 7 ]. The figure was digitally created using Clip Studio (Celsys, Inc., Tokyo, Japan) and enhanced by the authors based on anatomical references of Netter FH, "Atlas of Human Anatomy" (8th ed.) [ 8 ]. Ultrasound (US) was performed with the patient in the supine position using a 12-18 MHz linear transducer and demonstrated focal thickening of the genitofemoral nerve (Figure 2 ). A targeted ultrasound-guided diagnostic nerve block with 2 mL of 2% lidocaine produced immediate complete pain relief lasting several hours (NRS 1/10). No immediate adverse effects were reported at this time. A confirmatory block performed two weeks later with 2 mL of 2% lidocaine again yielded reproducible complete relief (NRS 0/10), strongly supporting a postsurgical peripheral neuropathic pain generator. A stepwise, US-guided perineural treatment strategy was pursued. Perineural hydrodissection was performed using 2 mL of 2% lidocaine with epinephrine, 2 mL of 5% dextrose, and 4 mL (4 mg) of dexamethasone, resulting in immediate clinically meaningful improvement (NRS 2/10). Because symptoms remained functionally limiting, US-guided pulsed radiofrequency (PRF) neuromodulation was subsequently performed using a 22-gauge Stryker (Stryker Corporation, Kalamazoo, MI, USA) RF cannula with a 5-mm active tip, positioned under ultrasound guidance as parallel as possible to the femoral branch of the genitofemoral nerve (Figure 3 ). Sensory stimulation confirmed concordant paresthesia before treatment. PRF was delivered in two cycles (20-ms pulse width, 2 Hz, 45 V, and 90 seconds per cycle) while maintaining the temperature below 42 °C. The figure was digitally created using Clip Studio (Celsys, Inc., Tokyo, Japan) and anatomically adapted by the authors based on classical neuromodulation theory, with the radiofrequency waves as parallel as possible to the nerve. At three months, the NRS score was 4/10, with partial reduction in analgesic use and functional limitation. At six months, the NRS score decreased to 1/10, with further functional improvement and decreased reliance on analgesics (Table 1 ). Timeline of interventions, pain intensity measured using the NRS, and clinical outcomes in a patient with postsurgical neuropathic pelvic/inguinal pain managed with a stepwise ultrasound-guided perineural approach. NRS: Numeric Rating Scale; US: ultrasound

Neuropathic pain is typically characterized by burning or electric shock-like sensations, allodynia, and hyperalgesia [ 1 , 2 ]. Persistent postsurgical pain is common [ 2 , 3 ]; however, the relative contribution of neuropathic mechanisms remains incompletely defined. The genitofemoral nerve provides sensory innervation to the lateral lower abdomen, upper anterior thigh, and genital region and may be vulnerable to injury because of its course near the inguinal region [ 3 , 4 ]. Ultrasound enables visualization of superficial nerves and precise diagnostic blocks, with reproducible pain relief supporting a peripheral neuropathic pain generator [ 3 - 5 ]. This report describes a suspected case of postsurgical genitofemoral neuropathy, an uncommon and potentially underrecognized cause of persistent pelvic and groin pain following lower abdominal cosmetic surgery. We outline a stepwise image-guided diagnostic and therapeutic approach and highlight the potential role of considering peripheral nerve injury in selected patients with persistent pelvic pain.

The clinical course of this patient illustrates a diagnostic pitfall in persistent postsurgical pelvic pain. After liposculpture and abdominoplasty, the patient developed persistent burning and electric shock-like pain in the inguinal region, along with tactile allodynia, hyperalgesia, and a positive Tinel sign along the surgical scar. Despite extensive evaluation and treatment for other potential pelvic pain contributors, her symptoms persisted. This sequence highlights how peripheral neuropathic pain generators may remain unrecognized when multiple potential etiologies coexist [ 1 - 5 ]. Persistent postsurgical pain is a well-described clinical entity, affecting approximately 10-50% of patients after major abdominal or pelvic surgery, particularly procedures involving extensive tissue dissection or potential nerve manipulation [ 2 , 3 , 9 ]. However, these estimates are largely derived from non-cosmetic surgical populations and cannot be directly extrapolated to cosmetic abdominal procedures. Although the true incidence after cosmetic abdominal surgery remains unclear, nerve traction, transection, scarring, and postoperative entrapment are recognized mechanisms across postsurgical cutaneous nerve entrapment syndromes [ 9 ]. In this case, focused neuropathic assessment raised suspicion for genitofemoral nerve injury and redirected the diagnostic and therapeutic strategy. The main diagnostic strength of this case was the concordance among clinical findings, ultrasound localization, and functional confirmation. The US image demonstrated focal thickening of a superficial nerve in the inguinal region consistent with the genitofemoral nerve. In addition, two low-volume ultrasound-guided diagnostic blocks each produced immediate, complete, but temporary pain relief, strongly supporting a peripheral neuropathic pain generator. Although the ilioinguinal, iliohypogastric, and genitofemoral nerves may all contribute to groin pain and have overlapping sensory territories, several clinical and procedural findings supported predominant genitofemoral nerve involvement in this case [ 1 , 9 ]. Clinically, the patient’s pain distribution was localized to the anterior groin and proximal medial thigh, consistent with the femoral branch of the genitofemoral nerve, rather than the more superior iliohypogastric or inferomedial ilioinguinal sensory territories. US evaluation did not reveal focal abnormalities along the expected course of the ilioinguinal or iliohypogastric nerves, whereas the genitofemoral nerve was identified in a location concordant with the patient’s maximal tenderness. Furthermore, a targeted US-guided diagnostic block at the genitofemoral nerve resulted in immediate and substantial pain relief, supporting its role as the primary pain generator. Some sensory overlap cannot be excluded; however, the concordance of anatomical, clinical, and interventional findings supports a diagnosis of suspected postsurgical genitofemoral neuropathy [ 1 , 9 ]. This diagnostic confirmation allowed progression to a stepwise US-guided treatment approach. Because peripheral nerves are small, ultrasound plays an important role in both the assessment of peripheral nerve disorders and the guidance of targeted perineural interventions [ 3 , 4 ]. Perineural hydrodissection is intended to separate the nerve from surrounding fibrotic tissue or adhesions, potentially restoring nerve mobility and reducing mechanical irritation [ 4 , 10 ].The injectate combined local anesthetic for immediate symptom modulation, dextrose as a commonly used hydrodissection medium, and corticosteroid to reduce perineural inflammation. The total volume was carefully titrated to achieve perineural distribution while limiting excessive spread, particularly given the close anatomical relationship with adjacent groin nerves. In this case, perineural hydrodissection resulted in immediate clinically meaningful improvement (NRS 2/10), supporting continued treatment and suggesting that ongoing mechanical irritation may have contributed to persistent symptoms. Subsequent PRF neuromodulation was associated with sustained pain reduction at three- and six-month follow-up, with functional improvement and decreased analgesic use. PRF has been proposed as a neuromodulatory treatment that may modulate pain signalling without overt thermal neurodestruction, although its mechanisms and clinical efficacy remain incompletely understood [ 11 ]. Collectively, these findings underscore the importance of considering a peripheral nerve pain generator in patients with persistent pelvic or groin pain after abdominal surgery, particularly when treatment of other pelvic etiologies has not resolved symptoms. This case also highlights how focused neuropathic clinical assessment, ultrasound imaging, and functional confirmation with diagnostic nerve blocks may help identify patients who could benefit from targeted intervention. The main limitation of this report is that it represents a single-case experience without surgical confirmation of nerve injury. Additional limitations include the potential for local anesthetic spread to adjacent nerves, which may confound diagnostic specificity; the possibility of placebo response; the known overlap in sensory territories among the ilioinguinal, iliohypogastric, and genitofemoral nerves; the relatively short follow-up period; and the absence of objective functional outcome measures beyond patient-reported improvement. Nevertheless, this approach may help identify otherwise overlooked peripheral nerve injuries and guide minimally invasive, image-guided therapies capable of providing durable symptom relief in selected patients. Further studies with longer follow-up are needed to better characterize the durability of pain relief after perineural hydrodissection and PRF neuromodulation in this population.

Peripheral abdominal nerve injury should be considered in patients with persistent postsurgical pelvic or groin pain with neuropathic features. Ultrasound-guided evaluation enables precise anatomical localization and supports both diagnostic confirmation and targeted interventional management.