False-positive diagnosis of uterine malignancy with raised 18F-fluorodeoxyglucose activity in adenomyosis: A case report

Wu Shun Felix Wong, Kwok To Thomas Li
In: World Journal of Advanced Research and Reviews 13(2) 367-370 · 2022 · doi:10.5281/zenodo.6349820 · W4225620734
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-10 ⓘ

This case report describes a patient with adenomyosis who received a false-positive diagnosis of uterine malignancy due to raised 18F-fluorodeoxyglucose activity on PET-CT, highlighting the risk of unnecessary surgery.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-10 · read from full text ⓘ

This case report describes a patient with adenomyosis who was initially misdiagnosed with uterine malignancy due to elevated 18F-fluorodeoxyglucose uptake on PET-CT imaging. The authors highlight that benign conditions like adenomyosis can mimic cancerous lesions through increased metabolic activity, potentially leading to unnecessary surgical interventions if clinicians are unaware of this possibility. The paper emphasizes the importance of recognizing these false-positive results to avoid unwarranted invasive procedures and excessive radiation exposure associated with further diagnostic workups. Relevance to endometriosis: This paper is centrally about adenomyosis, which it discusses as a benign condition capable of causing false-positive PET-CT findings often mistaken for malignancy.

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Abstract

Positron Emission Tomography - Computed Tomography (PET-CT) has been used to diagnose malignancy before surgery. However, there may be an increase in 18F-fluorodeoxyglucose (FDG) uptake in PET scans in benign conditions, leading to a false-positive diagnosis of malignancy and unnecessary surgery. This PET-CT investigation is expensive and is not without risk, including radiation and drug or contrast hypersensitivity. Although variable uterine uptakes of FDG activities in PET-CT had been reported in the literature, unawareness of its possibility in benign conditions could lead to a false alarm of malignancy. This paper reported a patient with a false-positive FDG finding presenting as a malignant uterine lesion for surgery, aiming to raise the clinical awareness of this finding.
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False-positive diagnosis of uterine malignancy with raised 18F-fluorodeoxyglucose activity in adenomyosis: A case report Authors/Creators - 1. Department of Obstetrics and Gynaecology, School of Women's and Children's Health, The University of New South Wales, Sydney, Australia. - 2. Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, China. Description Positron Emission Tomography - Computed Tomography (PET-CT) has been used to diagnose malignancy before surgery. However, there may be an increase in 18F-fluorodeoxyglucose (FDG) uptake in PET scans in benign conditions, leading to a false-positive diagnosis of malignancy and unnecessary surgery. This PET-CT investigation is expensive and is not without risk, including radiation and drug or contrast hypersensitivity. Although variable uterine uptakes of FDG activities in PET-CT had been reported in the literature, unawareness of its possibility in benign conditions could lead to a false alarm of malignancy. This paper reported a patient with a false-positive FDG finding presenting as a malignant uterine lesion for surgery, aiming to raise the clinical awareness of this finding. Files WJARR-2022-0178.pdf Files (960.9 kB) | Name | Size | Download all | |---|---|---| | md5:53440d2936a7f9b6ad8c7992edad0a55 | 960.9 kB | Preview Download |

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