A rare case of Castleman disease presented with diffuse ground glass nodules in both lungs

Castleman disease(CD), also known as giant lymphadenopathy or angiofollicular lymphadenopathy, was firstly reported by Castleman in 1954[1]. CD is a rare chronic lymphoproliferative disease, and its etiology and pathogenesis is still not completely clear. Clinically, according to the distribution of swollen lymph nodes, CD is divided into Unicentric CD (UCD) and multicentric CD (MCD). The main manifestations of UCD are single-site lymph node enlargement, lack of specific clinical manifestations and abnormal laboratory indicators. MCD mostly presents as diffuse lymphadenopathy, which is a rare polyclonal B lymphoproliferative disorder that straddles the intersections of hematology, oncology, rheumatology, and virology[2]. CD that presents with diffuse parenchymal lung disease is extremely rare. Here, we report a 48-year-old woman diagnosed with CD, which presents with diffuse nodules in both lungs.