Studies on Gestational Function in Rat Models of Endometriosis Induced by Endometrium Autotransplantation

[Objective] Gestational function of endometriosis (EMT) model induced by endometrium autotransplantation was observed to verify its feasibility for the research of pathological status of human infertility induced by EMT. [Methods] EMT rat models were established by endometrium autotransplantation according to the literature. The endocrine and immune function and the gestational function in model rats (Group B) were observed and were compared with the normal rats (Group A). [Results] The pathologic changes such as the increase of serum tumor necrosis factor occur in the model rats (P 0.01 as compared with Group A); luteinizing hormone (LH) level was decreased and prolactin (PRL) level increased in the serum of proestrus EMT model; serum progestogen content was decreased in metestrus models (P 0.01). The amount of ovulation and live fetus and imbedding rate were less than those in Group A. [ Conclusion] The disorder of genital, endocrine and immune function iind the gestational hypofunction in EMT models induced by autotransplantation can represent the status of EMT infertility and can be used as the EMT model for the research of gestation and proconceptive drugs.