Development and Evaluation of Dienogest Vaginal Tablet for Treatment of Endometriosis
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This study developed and evaluated dienogest vaginal tablets for endometriosis treatment, identifying formulation VT6 as optimal based on physical properties and in-vitro dissolution.
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Abstract
Vaginal delivery is an important route of drug administration for gynecological diseases. The advantages of vaginal route are large surface area, rich blood supply, avoidance of first pass effect, relatively high permeability of many drugs and self insertion. The aim of the present work was to develop Dienogest containing vaginal tablet for the treatment of endometriosis. Five different formulations were prepared, using different compositions of Corn Starch, Microcrystalline Cellulose and Crospovidone. The tablets were evaluated for hardness, friability, disintegration time, drug content and release. Formulation VT6 was found to be the best among all formulations based on physical properties and in-vitro dissolution profile.
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- Endometriosis: An Overview of the Disease and Its Treatment via openalex
- W1932806045 via openalex
- W2040458748 via openalex
- W2045458073 via openalex
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
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