Atypical polypoid adenomyomas of the endometrium

Mazur MT, M T Mazur
The American journal of surgical pathology · 1981 · doi:10.1097/00000478-198107000-00006 · PMID:7282995
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This study describes atypical polypoid adenomyomas in premenopausal women, demonstrating their benign, noninvasive nature and lack of recurrence after conservative management or hysterectomy.

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Mazur describes five cases of atypical polypoid adenomyomas, unusual endometrial lesions occurring in premenopausal women. These growths feature irregular atypical glands with squamous metaplasia and a cellular smooth muscle component, distinguishing them from malignant tumors like infiltrating adenocarcinoma or mixed müllerian tumors. The study notes that while two patients who underwent hysterectomies had residual lesions confined to the endometrium, follow-up ranging from four to twenty-four months showed no recurrence and one patient successfully conceived after a normal dilation and curettage. Based on this benign behavior, the author suggests these lesions can be managed conservatively without immediate hysterectomy in premenopausal patients. This paper is centrally about adenomyosis — specifically describing a rare variant known as atypical polypoid adenomyoma involving endometrial glands within a smooth muscle stroma.

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Abstract

Five unusual polypoid lesions of the endometrium which we term atypical polypoid adenomyomas are described; these growths occurred in premenopausal women. Each of the polyps was characterized by irregular atypical glands with squamous metaplasia and a cellular, smooth muscle mesenchyme, having a pattern to be distinguished from infiltrating adenocarcinoma or a malignant mixed müllerian tumor. Electron microscopy in one case confirmed the presence of a well-differentiated smooth muscle component. These lesions were focal and noninvasive. Two of the three patients who had hysterectomies has small residual lesions confined to the endometrium. Follow-up from 4 to 24 months showed no recurrence. One patient had a second D & C reported as normal; she subsequently became pregnant. The benign behavior of these unusual polyps suggests that atypical adenomyomas can be managed conservatively in the premenopausal woman without the necessity of a hysterectomy.
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Atypical polypoid adenomyomas of the endometrium - Michael T. Mazur Five unusual polypoid lesions of the endometrium which we term atypical polypoid adenomyomas are described; these growths occurred in premenopausal women. Each of the polyps was characterized by irregular atypical glands with squamous metaplasia and a cellular, smooth muscle mesenchyme, having a pattern to be distinguished from infiltrating adenocarcinoma or a malignant mixed müllerian tumor. Electron microscopy in one case confirmed the presence of a well-differentiated smooth muscle component. These lesions were focal and noninvasive. Two of the three patients who had hysterectomies had small residual lesions confined to the endometrium. Follow-up from 4 to 24 months showed no recurrence. One patient had a second D & C reported as normal; she subsequently became pregnant. The benign behavior of these unusual polyps suggests that atypical adenomyomas can be managed conservatively in the premenopausal woman without the necessity of a hysterectomy.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Uterine Neoplasms Adult Endometriosis Endometriosis Female Humans Uterine Neoplasms

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europepmc
last seen: 2026-09-13T09:25:22.628771+00:00
pubmed
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