Pembrolizumab-Induced Lichen Planus in a Patient with Metastatic Pulmonary Giant Cell Carcinoma: A Case Report and Literature Review

Pembrolizumab-Induced Lichen Planus in a Patient with Metastatic Pulmonary Giant Cell Carcinoma: A Case Report and Literature Review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 14 July 2025 V1 Latest version Share on Pembrolizumab-Induced Lichen Planus in a Patient with Metastatic Pulmonary Giant Cell Carcinoma: A Case Report and Literature Review Authors : Elinkichari Dorsaf 0000-0003-0307-1835 [email protected] , Dorsaf Elinkichari , Juliet Tantot , and Stéphane Dalle Authors Info & Affiliations https://doi.org/10.22541/au.175251221.13492640/v1 114 views 115 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Ιmmune checkpoint inhibitors (ICIs) have revolutionized the management of advanced cancers. Nevertheless, the oncologic response is often achieved at the cost of immune-related adverse events (irAEs). We present a case of an immune-mediated lichen planus (LP) and a literature review of similar cases. A 60-year-old man, who is being treated with pembrolizumab for a pulmonary giant cell carcinoma since April 2022, presented in November 2022 with a pruritic eruption that appeared two weeks ago. Examination showed bright purple confluent scaly papules on wrists, proximity of limbs, back and buttocks and palmar keratoderma made of violaceus papules covered with reticular white striae. Histological examination revealed an epidermal hyperplasia, vacuolization of the basal layer, necrotic keratinocytes and a band-like subepidermal lymphocytic infiltrate with many eosinophils. The diagnosis of an immune-related LP was retained. Pembrolizumab was withheld because of the severity and the extension of the lesions. Superpotent topical steroids were prescribed with a significant improvement of the rash within 3 weeks. Immune-mediated lichenoid euptions represent one of the most frequent dermatologic irAEs. In our patient, the onset seven months after the initiation of ICIs, the infiltrate rich in eosinophils, and the rapidly diffused character are indications of an immuno-mediated LP. Supplementary Material File (pembrolizumab-induced lichen planus.pdf) Download 555.01 KB Information & Authors Information Version history V1 Version 1 14 July 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords anti-pd1 dermatology drug reactions ici: ιmmune checkpoint inhibitors, lp: lichen planus immunotherapy lichen planus pembrolizumab Authors Affiliations Elinkichari Dorsaf 0000-0003-0307-1835 [email protected] View all articles by this author Dorsaf Elinkichari Service de Dermatologie, CHU Lyon Sud View all articles by this author Juliet Tantot Service d'Anatomopathologie, CHU Lyon Sud View all articles by this author Stéphane Dalle Service de Dermatologie, CHU Lyon Sud View all articles by this author Metrics & Citations Metrics Article Usage 114 views 115 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Elinkichari Dorsaf, Dorsaf Elinkichari, Juliet Tantot, et al. Pembrolizumab-Induced Lichen Planus in a Patient with Metastatic Pulmonary Giant Cell Carcinoma: A Case Report and Literature Review. Authorea . 14 July 2025. 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