Comparison of the efficacy and safety of two formulations of micronized progesterone (ellios™and utrogestan™) used as luteal phase support after in vitro fertilization

Marc Germond, Paola Capelli, Giuliana Bruno, Sara Vesnaver, A. Senn, Alfred Senn, Nathalie Rouge, N. Rouge, J Biollaz
Fertility and sterility · 2002 · vol. 77(2) , pp. 313–317 · doi:10.1016/s0015-0282(01)02979-x · PMID:11821089 · W1977073553
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Abstract

ObjectiveTo compare the efficacy and the tolerability of two different vaginal formulations of micronized progesterone, Ellios and Utrogestan, used for luteal phase support after an in vitro fertilization (IVF) cycle.DesignCohort study.SettingFertility center in a university hospital. PATIENT(S(: One hundred twenty-three women who underwent IVF/intracytoplasmic sperm injection (ICSI) stimulated cycles from October 1998 to March 2000, who had at least six follicles of > or =14 mm on the day of hCG administration.Intervention(s)Patients received Ellios pessaries (2 times 200-mg pessary/day) or Utrogestan capsules (2 x 100-mg capsules, two times a day). Progesterone was administered from the day of oocyte pickup (day 0) until menses or up to 10 weeks in pregnant patients.Main outcome measure(s)Progesterone levels, pregnancy rate, and tolerability tested by patient questionnaire.Result(s)The progesterone levels on days 0, 9, 16 were not statistically different between the two formulations. The pregnancy rate were similar in groups 1 and 2 (25.5% vs. 18.6%), whereas tolerance was significantly better in group 1 versus group 2 (vaginal discharge: 43% vs. 82%).Conclusion(s)The efficacy of the two formulations of progesterone is comparable, although the patient tolerance for Ellios is better.

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