Long-term survival in multiple primary lung cancer with immune-based combination therapy: a case report

Long-term survival in multiple primary lung cancer with immune-based combination therapy: a case report | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Long-term survival in multiple primary lung cancer with immune-based combination therapy: a case report Rui Zhang, Hong-Xia Zhao, Chong-Hua Liu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8482417/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract With the increasing prevalence of multiple lung nodules detected through low-dose computed tomography (CT) screening, the proportion of multiple primary lung cancer (MPLC) among all lung cancers is rising. The diagnosis and treatment of MPLC continue to present obstacles and problems. It is frequently misidentified as intrapulmonary metastasis (IPM). Although surgery is considered the optimal therapeutic approach, many patients present with distant metastases at the time of diagnosis, thereby losing the opportunity for surgical intervention. We present a case of a 69-year-old man who had small-cell carcinoma in his left upper lobe and adenocarcinoma in his left lower lobe. Following his initial diagnosis, he received a comprehensive treatment regimen including immunotherapy, chemotherapy, and localized radiation therapy over one year, achieving remission lasting four and a half years. Multiple primary lung cancer long-term survival immunotherapy case report Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8482417","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":580394543,"identity":"5ceda1ab-047d-447f-99e7-70329334befc","order_by":0,"name":"Rui Zhang","email":"","orcid":"","institution":"Linyi People's Hospital","correspondingAuthor":false,"prefix":"","firstName":"Rui","middleName":"","lastName":"Zhang","suffix":""},{"id":580394544,"identity":"46706481-efd8-43bf-b9cd-e66f6025fb4b","order_by":1,"name":"Hong-Xia Zhao","email":"","orcid":"","institution":"Linyi People's Hospital","correspondingAuthor":false,"prefix":"","firstName":"Hong-Xia","middleName":"","lastName":"Zhao","suffix":""},{"id":580394545,"identity":"28f58012-454d-460f-837e-d7736ae6225f","order_by":2,"name":"Chong-Hua Liu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyElEQVRIie3QMQrCMBTG8VcKyfKojq8UegMhpVCcepYGBxeRjp3UUkiv0Elv4dzi4KJ3sDfI6OBgZkEaN4f85/xIvgC4XH9YAMifWlDMeF2P2oYwQAi7cpkGeGlSsiUR6koeaa3maEX4vU86QZ4KRwUEebw4TBHcFoXZ4rNIqkcJqzTrpwihGMwtzJBWEPTybEGSBgUhCwdFaElS3xBiZo4lwU3mmYcJhtJ8srDYMuO3DPRrtz+113HUVR5Pko/Eb8ddLpfL9aU3+WI3XP0nWGgAAAAASUVORK5CYII=","orcid":"","institution":"Linyi People's Hospital","correspondingAuthor":true,"prefix":"","firstName":"Chong-Hua","middleName":"","lastName":"Liu","suffix":""}],"badges":[],"createdAt":"2025-12-30 14:53:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8482417/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8482417/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":101855346,"identity":"6f1aae83-e713-4da7-8480-39af22c6f9a0","added_by":"auto","created_at":"2026-02-04 10:42:40","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":10169379,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8482417/v1_covered_c4cb8df8-9cf3-48e8-b461-178fd8b65713.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Long-term survival in multiple primary lung cancer with immune-based combination therapy: a case report","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Multiple primary lung cancer, long-term survival, immunotherapy, case report","lastPublishedDoi":"10.21203/rs.3.rs-8482417/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8482417/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eWith the increasing prevalence of multiple lung nodules detected through low-dose computed tomography (CT) screening, the proportion of multiple primary lung cancer (MPLC) among all lung cancers is rising. 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