Squamous cell carcinoma of the ovary--a case report

K Shimamatsu, Shimamatsu K, A Iemura, Iemura A, Nakashima O, O Nakashima, Taguchi J, J Taguchi, M. Inoue, Inoue M, Higaki K, K Higaki, Kojiro M, M Kojiro, Kataoka A, A Kataoka, T Nishida, Nishida T, M Yakushiji, Yakushiji M
The Kurume medical journal · 1994 · doi:10.2739/kurumemedj.41.177 · PMID:7700049
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This case report describes a 68-year-old woman with ovarian squamous cell carcinoma arising from surface epithelial inclusion cysts, suggesting a fourth possibility for the tumor's histogenesis.

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This 1994 case report describes a 68-year-old woman with one month of lower abdominal pain and weight loss, whose imaging showed a large right ovarian mass; she underwent total hysterectomy and bilateral salpingo-oophorectomy, and the tumor was diagnosed as squamous cell carcinoma (SCC) of the ovary. The patient died five months after surgery from infection and disseminated intravascular coagulation, and the authors state that clinical and autopsy examinations found the primary SCC lesion only in the right ovary. Histopathology did not find mature cystic teratoma, Brenner tumor, or endometriosis—common proposed histogenetic sources of ovarian SCC—but instead observed surface epithelial inclusion cysts with squamous metaplasia in non-cancerous tissue and confirmed a contiguous transition from metaplastic cyst wall to SCC using stepwise serial sections. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

A 68-year-old woman presented a one-month history of lower abdominal pain and weight loss, and was admitted to our hospital. On physical examination, a large hard mass was palpated in her right lower abdomen. An ultrasonograph and computed tomographic (CT) scan revealed a right ovarian tumor that measured 6.9 x 4.9 cm in size. A total hysterectomy and bilateral salpingo-oophorectomy were performed. The postoperative diagnosis of the tumor was squamous cell carcinoma (SCC) of the ovary. She died of infection and disseminated intravascular coagulation 5 months after surgery. The clinical and autopsy examinations did not show the primary lesions of SCC except in the right ovary. Mature cystic teratoma, Brenner tumor and endometriosis, which are ordinary regarded as the histogenesis of ovarian SCC, were not found, but a few surface epithelial inclusion cysts with squamous metaplasia were observed in non-cancerous area of the right ovary, and the contiguous transition from the metaplastic cyst wall to SCC was confirmed by stepwise serial sections. The present case suggests that the surface epithelium of ovary could be the fourth possibility in the histogenesis of the ovarian SCC.
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Keywords

ovary, ovarian cancer, surface epithelial inclusion cyst, squamous metaplasia, squamous cell carcinoma 1994 Volume 41 Issue 4 Pages 177-182 Details

Abstract

A 68-year-old woman presented a one-month history of lower abdominal pain and weight loss, and was admitted to our hospital. On physical examination, a large hard mass was palpated in her right lower abdomen. An ultrasonograph and computed tomographic (CT) scan revealed a right ovarian tumor that measured 6.9.4.9 cm in size. A total hysterectomy and bilateral salpingo-oophorectomy were performed. The postoperative diagnosis of the tumor was squamous cell carcinoma (SCC) of the ovary. She died of infection and disseminated intravascular coagulation 5 months after surgery. The clinical and autopsy examinations did not show the primary lesions of SCC except in the right ovary. Mature cystic teratoma, Brenner tumor and endometriosis, which are ordinary regarded as the histogenesis of ovarian SCC, were not found, but a few surface epithelial inclusion cysts with squamous metaplasia were observed in non-cancerous area of the right ovary, and the contiguous transition from the metaplastic cyst wall to SCC was confirmed by stepwise serial sections. The present case suggests that the surface epithelium of ovary could be the fourth possibility in the histogenesis of the ovarian SCC. © THE KURUME MEDICAL JOURNAL Favorites & Alerts Recently viewed articles

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Squamous Cell Ovarian Neoplasms Aged Carcinoma, Squamous Cell Female Humans Ovarian Neoplasms

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