Phytocompounds Targeting for the Treatment of β-Thalassemia: A Review

For treating β-thalassemia, increasing foetal haemoglobin (HbF) production with drugs shows promising result. Many studies have focused on finding new HbF-inducing phytocompounds and understanding how they work. This review compiles the identified agents so far. While these agents can stimulate HbF production, chemotherapy drugs cannot be practically used for treating β-haemoglobinopathies, like β-thalassemia, due to their toxicity and growth-inhibiting effects. To overcome this issue, researchers are exploring natural plant sources for effective, safe, and easy-to-use HbF-inducing agents. This review highlights summarizes the natural phytocompounds that stimulate HbF production, aiming to provide new insights into future treatments for β-thalassemia.