Expression of a human multidrug resistance gene in human ovarian carcinoma cell lines

Sekiya S, S Sekiya, Nunoyama T, T. Nunoyama, Shirasawa H, H Shirasawa, H. Kimura, Kimura H, M Kawata, Kawata M, N Iijima, Iijima N, Y Sugimoto, Sugimoto Y, Tsuruo T, T Tsuruo, H Takamizawa, Takamizawa H
Archives of gynecology and obstetrics · 1992 · vol. 251(2) , pp. 79–86 · doi:10.1007/bf02759915 · PMID:1349803
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Researchers analyzed mdr 1 expression in eight human ovarian adenocarcinoma cell lines, finding that mRNA transcripts were present only in the most resistant line without DNA amplification, suggesting mdr 1 contributes to chemoresistance.

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Abstract

To investigate the possible role of the multidrug resistance phenotype to chemoresistance in human ovarian carcinoma, we have analyzed human multidrug resistance gene (mdr 1) expression in 8 human ovarian adenocarcinoma cell lines. An increase in P-glycoprotein level specific to multidrug-resistant tumor cells was not apparently associated with the increase in resistance to vincristine (VCR) or doxorubicin (Adriamycin). Mdr 1 transcripts (4.5 kilobases) were observed in the RNA preparation obtained from only one cell line (SHIN-3) that showed the highest resistance to both drugs in vitro and in vivo. No cell lines showed mdr 1 DNA amplification. These results suggest that the insensitivity of human ovarian carcinoma to chemotherapy could be partly explained by the expression of mdr 1.

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MeSH descriptors

Gene Expression Regulation, Neoplastic Membrane Glycoproteins Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma ATP Binding Cassette Transporter, Subfamily B, Member 1 Cell Division Cell Division Cell Line Cystadenocarcinoma Cystadenocarcinoma Cystadenocarcinoma Cystadenocarcinoma Doxorubicin Doxorubicin Endometriosis Endometriosis Endometriosis

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europepmc
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