Pathology Change of Endometriosis Rats Treated by Human Chorionic Gonadotropin

【Objective】To investigate the pathology change of endometriosis(EMs) rats which were treated by human chorionic gonadotropin(HCG).【Method】Twenty-four endometriosis rat models were established and were divided into three groups,then were treated with 258 U/kg(low dose group) and 516 U/kg(high-dose group) of HCG respectively and 0.9% NaCl as a control for 15 days(3 estrous cycles),the ectopic lesion volume change and endometrium,ectopic endometrium endometrial tissue HE staining changes were investigated.【Results】There was no significant difference among the three groups [(208 ± 99) cm3,(219 ± 109) cm3,and(210 ± 124) cm3,respectively] of the ectopic lesion volume(P 0.05).The ectopic lesion volume of low-dose group and high dose group of HCG [(64 ± 62) cm3 and(54 ± 27) cm3,respectively] were smaller than the control group(203 ± 102) cm3(P 0.05).Eutopic endometrium and ectopic endometrial glandular epithelial cells was inhibited state,the performance was as a reduction of the cytoplasm,enrichment of nuclear stain and the nuclear shrink and so on.【Conclusion】From histological morphology analysis,HCG treatment in endometriosis rats has a certain effect.