The Research Progress of Relationship between YKL-40 and Gynecological Diseases

YKL-40 is one of mammalian chitnase members and secreted by macrophage,neutrocyte,chondrocyte,endotheliocyte,vascular smooth muscle cell and some entity tumor cells.Immunohistochemical assay has found that YKL-40 is expressed in many human tissues with a varying degree.In healthy young group,the expression of serum YKL-40 is in low level and has no deference between male and female.Studies suggest that there are a high expression of YKL-40 protein in the peritoneum of peritoneal endometriosis,eutopic and ectopic endometrium of adenomyosis,ovarian cancer tissues and endometrial cancer tissues.Serum YKL-40 is elevated in ovarian cancer,endometrial cancer and cervical cancer and is related with shortened survival,elevated serum YKL-40 level before treatment indicates a poor prognosis.