Histologic Features and Decreased Lung FOXF1 Gene Expression in Severe Bronchopulmonary Dysplasia without a Genetic Diagnosis of Alveolar Capillary Dysplasia
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Abstract
Severe BPD can be associated with clinical and histologic features that are similar to ACD without evidence of FOXF1 genetic disease. Importantly, lung FOXF1 and TMEM100 gene expression is markedly decreased in severe BPD, suggesting that impaired FOXF1 signaling may contribute to abnormal lung growth and refractory pulmonary hypertension in BPD.
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- last seen: 2026-05-19T01:45:01.086888+00:00