Robust information routing by dorsal subiculum neurons

The hippocampus conveys various information associated with spatial navigation; yet, information distribution to multiple downstream areas remains unknown. We investigated this by identifying axonal projections using optogenetics during large-scale recordings from the rat subiculum, the major hippocampal output structure. Subicular neurons demonstrated a noise-resistant representation of place, speed, and trajectory, which was as accurate as that of hippocampal CA1 neurons. Speed and trajectory information was most prominently sent to the retrosplenial cortex and nucleus accumbens, respectively. Place information was distributed uniformly to the retrosplenial cortex, nucleus accumbens, anteroventral thalamus, and medial mammillary body. Information transmission by projection neurons was tightly controlled by theta oscillations and sharp-wave/ripples in a target region-specific manner. In conclusion, the subiculum robustly routes diverse navigation-associated information to downstream areas. One Sentence Summary The subiculum accurately and robustly represents diverse information and routes it in a target region-specific manner.