The Alterations of Serum IgG Fucosylation as a Potential Additional New Diagnostic Marker in Advanced Endometriosis

Sołkiewicz,Katarzyna, Katarzyna Sołkiewicz, Hubert Krotkiewski, Jędryka,Marcin, Marcin Jędryka, Czekański,Andrzej, Andrzej Czekański, Ewa Maria Kratz
In: Journal of Inflammation Research, Vol Volume 15, Pp 251-266 (2022) · 2022 · W4225769948
article OA: green CC0 ⤵ 6 in-corpus citations
🔓 Open OA copy View on OpenAlex
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Serum IgG reactivity with fucose-specific lectins AAL, LCA, and LTA can serve as a diagnostic marker for advanced endometriosis without requiring prior IgG isolation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated whether serum IgG fucosylation patterns are associated with advanced endometriosis and whether native IgG fucosylation could be measured directly in serum without prior IgG isolation to support non-invasive diagnostics. Using lectin-ELISA with fucose-specific lectins (AAL and LCA for core α1,6-linked fucose, and LTA and UEA for α1,3- and α1,2-linked fucose), the authors analyzed serum IgG reactivities and applied ROC curve analysis and cluster analysis. They found that specific serum IgG reactivities to a panel of lectins (AAL, LCA, and LTA) could distinguish women with advanced endometriosis from healthy controls, and they reported that the “native” serum approach was sufficient for differentiation. This paper is centrally about endometriosis — it proposes serum IgG fucosylation lectin-ELISA reactivity as an additional diagnostic marker for advanced endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Katarzyna Sołkiewicz, 1 Hubert Krotkiewski, 2 Marcin Jędryka, 3, 4 Andrzej Czekański, 3, 4 Ewa Maria Kratz 1 1Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, 50-556, Poland; 2Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, 53-114, Poland; 3Department of Oncology, Gynecological Oncology Clinic, Faculty of Medicine, Wroclaw Medical University, Wroclaw, 53-413, Poland; 4Department of Oncological Gynecology, Wroclaw Comprehensive Cancer Center, Wroclaw, 53-413, PolandCorrespondence: Ewa Maria KratzDepartment of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, Wroclaw, 50-556, PolandTel +48 71 784 01 52Fax +48 71 784 01 54Email [email protected]: Endometriosis is an inflammatory disease leading to the growth of endometrial-like tissue outside of the uterus, which affects approximately 10% of young women of reproductive potential. The diagnosis of this disease is difficult, often invasive and time-consuming, therefore non-invasive diagnostic methods are strongly desirable in endometriosis detection. The aim of our project was to investigate whether any associations exist between the expression of serum IgG fucosylation and advanced stages of endometriosis. We were also interested in whether native serum IgG (s-IgG) fucosylation analysis, without prior IgG isolation, could provide a panel of parameters helpful in non-invasive diagnostics of advanced endometriosis.Methods: IgG fucosylation was examined using a lectin-ELISA test with fucose-specific lectins: AAL and LCA, specific for core fucose α 1,6-linked, as well as LTA and UEA which recognize α 1,3- and α 1,2-linked fucose, respectively.Results: ROC curve and cluster analysis showed s-IgG reactivities with the panel of fucose-specific lectins AAL, LCA and LTA.Conclusion: s-IgG reactivity with the panel of fucose-specific lectins AAL, LCA and LTA can be taken into account as a useful diagnostic and clinical tool to differentiate women with advanced endometriosis. Moreover, it has been shown that the analysis of native IgG fucosylation directly in serum, without prior time-consuming, expensive IgG isolation, is sufficient to distinguish advanced stages of endometriosis from a control group of healthy women.Keywords: serum IgG, IgG fucosylation, lectin-ELISA, endometriosis

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (74)

Cited by (6)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK