Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis

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We performed this meta-analysis to illustrate the preliminary predictive value of TSP-1. Methods Twenty-four studies with a total of 2379 patients were included. A comprehensive literature search was performed by using PubMed, Cochrane Library, Web of Science, Embase, and hand searches were also conducted of relevant bibliographies. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for patient survival and disease recurrence were initially identified to explore relationships between TSP-1 expression and patient prognosis. Results A total of 24 eligible studies were included in this meta-analysis. Our results showed that high level of TSP-1 was correlated significantly with poor overall survival (OS) (HR=1.40, 95% CI: 1.17~1.68; P＜0.001). However, high TSP-1 expression predicted no significant impact on progression-free survival (PFS)/ metastasis-free survival (MFS) (HR=1.35, 95%CI: 0.87-2.10; P=0.176) and disease-free survival (DFS)/ recurrence-free survival (RFS) (HR = 1.40, 95%CI: 0.77–2.53; P=0.271). In addition, we performed subgroup analyses which showed that high TSP-1 expression predicted poor prognosis in breast cancer and gynecological cancer. Additionally, the relatively small number of studies on PFS/MFS and DFS/RFS is a limitation. The data extracted through Kaplan-Meier curves may not be accurate. Moreover, only English articles were included in this article, which may lead to deviations in the results. Conclusions Our findings indicated high TSP-1 expression may act as a promising biomarker of poor prognosis in cancers, especially in breast cancer and gynecological cancer. Medical Genetics TSP-1 Malignant neoplasm Prognosis Overall survival Meta-analysis Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Background Thrombospondin-1 (TSP-1) is one of the thrombospondin gene family, which be composed of five matricellular proteins includes TSP-1, -2, -3, -4, and -5 [1, 2]. Thrombospondin gene family plays a role in extensive physiological and pathological processes, including development, angiogenesis, inflammation and neoplasia [3]. This TSP family interact with a variety of membrane proteins on the cell surface, such as proteoglycans, integrins, CD36 and CD47 [4, 5]. Thus, during tissue development and remodeling, TSP family control cellular phenotype and extracellular matrix structure [3]. TSP-1 is a multifunctional matrix glycoprotein which is synthesized and secreted by platelets, endothelial cells and smooth muscle cells. Under the transmission microscope, TSP-1 is composed of three identical peptide chains, each showing a spherical amino at one end and a spherical carboxyl at the other end, connected by a slender rod-like arm in the middle [6]. Because of multiple functional domains, TSP-1 can mediate the interaction between cell and cell, cell and extracellular matrix. Therefore, TSP-1 is a kind of glycoprotein with a wide range of biological effects, such as activating transforming growth factor-β, inhibiting angiogenesis, anti-tumor activity, participating in tissue repair and so on [7, 8]. TSP-1 was originally found in platelets, but now it has been shown to play an important role in carcinogenesis [9, 10]. Besides its direct role in regulating the behavior of tumor cells, TSP-1 also shows function in tumor vessels [11]. Taken together, TSP-1 can regulate the growth, adhesion and migration of tumor cells [12]. The function of TSP 1 remains disputable in angiogenesis and tumor progression. In some cancers, TSP 1 has been deemed to be an inhibitor of both processes [13-15], while in others, it has been considered a stimulator [16-18]. Some research concluded that the actual function of TSP 1 was organ specific [19]. To address this issue, we performed meta-analysis to comprehensively assess the overall risk of TSP-1 for survival in patients with various types of cancers. Furthermore, we attempt to evaluate the value of TSP-1 as a prognostic marker in the aspect of clinical features and statistics. Methods Search strategy Original studies aimed to analyze the predictive value of TSP-1 in multiple human malignant neoplasms. PubMed, Web of Science, Cochrane Library and Embase were searched up from inception to December 14, 2019 using the following key words: “Thrombospondin 1”, “Neoplasm”, “prognosis”, “survival”, “recurrence”, “death”, “incidence”, “mortality”. The search strategy used a combination of Medical Subject Headings and thesaurus terms. Inclusion criteria and exclusion criteria We considered articles were considered qualified when they met the following criteria: (1) patients diagnosed with cancers by using pathological methods (2) studies focusing on the relationship between TSP-1 expression and prognosis, (3) survival outcomes with 95% confidence intervals (CIs) and hazard ratios (HRs) that could be extracted directly or indirectly. Excluding criteria were as follows: (1) Not a human study; (2) Not original articles; (3) Unrelated to TSP-1; (4) No clinical parameters; (5) Unrelated to malignant tumor; (6) Not related to prognosis or survival; (7) Insufficient survival data; (8) Overlapping data. Quality assessment Quality assessment of the included studies was conducted independently by three researchists (SS, HD and TY) to rule out any discrepancy. Studies for inclusion include the following criteria: (1) the study country and population; (2) definition of study design (3) the samples and pathology information; (4) defiition of measurement of TSP-1; (5) the clinical outcomes and follow-up duration. Data extraction All relevant studies were identified by two independent reviewers (TY and HD), and any disagreements were reassessed by a third reviewer (SS). The data elements include the following information: (1) publication year and first author’s name; (2) nationality, dominant ethnicity, number of patients, sample type, and main type of pathology; (3) Assay method, follow-up time; (4) TSP-1 expression levels and cut-off values; (5) HRs related to elevated TSP-1 expression for overall survival (OS), recurrence-free survival (RFS), and disease-free survival (DFS). Those indirectly reported HRs and 95% CIs were calculated using graphical survival plots. Statistical methods A random or fixed model was selected according the heterogeneity which was measured by the Q statistics and Higgins I-squared statistic (I 2 ). If P 50%, a random-effects model was applied and subgroup ana lyses was carried out to fine the source of heterogeneity; otherwise, a fixed-effects model was adopted [20]. Publication bias was assessed by Egger’s test and Begg’s funnel plot [21]. To examine the stability and dependability of the overall outcomes, sensitivity analyses were performed by excluding one single study one by one and recalculating their HRs. All P-values were calculated using a two-sided test. We consider P<0.05 as statistically significant. All statistical analyses were conducted by using Excel software 2016 and Stata version 12.0. Results Study selection The flow chart of study selection process was depicted in Figure 1. A total of 251 studies were identified from online databases, including PubMed, Cochrane Library, Web of Science and Embase. Based on screening of titles and abstracts, 54 studies were selected for further investigation according to following criteria: repetitive articles, not a human study, not original articles, no clinical parameters, unrelated to TSP-1, unrelated to malignant neoplasms and unrelated to prognosis or survival. Of these 54 studies, 30 were excluded due to insufficient survival data and overlapping data. Ultimately, 24 articles were included for further analysis. Study characteristics The major characteristics of the eligible data were summarized in Table 1. We collected basic data on 24 articles published between 2000 and 2019. The meta-analysis included 2379 participants from different regions of the United States, France, Japan, China, India, Greece, the United Kingdom and Norway, including tumors such as breast cancer, liver cancer, ovarian cancer, esophagus cancer, lung cancer, gastric cancer, colon cancer, skin cancer, cervical cancer, oral cancer and bladder cancer. The expression of TSP-1 was measured by Immunohistochemical staining (IHC) in the most of studies. Besides, Quantitative real-time polymerase chain reaction (qRT-PCR) assay and enzyme linked immunosorbent assay (ELISA) was applied to detect TSP-1 in 3 and 2 studies, respectively, and immunoblot analysis and a standard Dextran Polymer Conjugate Two-step Visualization System Envision was applied in 1 study each. The data of HR and 95% CI was extracted from survival curves or literature reports. In all these studies, 17 studies researched OS [17, 22-37], 7 studies investigated DFS/RFS [22, 23, 26, 38-41] and 6 studies focused on progression-free survival (PFS)/ metastasis-free survival (MFS) [28, 31, 32, 42-44] (Table 2). OS associated with TSP-1 expression Because of the mild heterogeneity (p=0.016, I 2 =47.3), the fixed effect model was used for data analysis. The results showed that high level of TSP-1 indicated poor OS, (HR=1.40; 95% CI: 1.17~1.68) and the effect was statistically significant (P＜0.001) (Figure 2A). In order to analyze the source of heterogeneity, we did subgroup analyses according to nationality, dominant ethnicity, main pathological type, disease type, assay method and source of HR. When stratified by ethnicity, we found that the high level of TSP-1 was significantly correlated with the OS of Caucasians (HR=1.74; 95%CI: 1.37-2.22; P＜0.001), while among Asians, there was no significant correlation (HR=1.07, 95%CI: 0.82-1.40; P=0.629) (Figure 3A). In the source of HR analysis, the OS of “reported” group was significantly worse(HR=1.48; 95%CI: 1.18~1.87; P=0.001), while the OS of the other group was also worse, however, with no statistical significance(HR=1.29; 95%CI: 0.97~1.171; P=0.081) (Figure 3B). According to the subgroup analysis of disease type, the pooled HR of breast cancer was 1.78(95%CI: 1.09~2.92; P=0.022) (I 2 =0.0%, P=0.536), and the pooled HR of gynecological cancer was 1.72(95%CI:1.13-2.64; P=0.012)(I 2 =0.0%, P=0.511), with no heterogeneity (Figure 3C). Finally, there was a significant relationship between elevated TSP-1 and poor OS in Americans. (HR=1.72; 95%CI: 1.13-2.64; P=0.012) (Figure 3E). Other kinds of diseases had no obvious significance (Figure 3D, 3F). PFS/MFS and DFS/RFS associated with TSP-1 expression Six studies were included in the PFS/MFS analysis, in which a random-effect model was used because of the significant heterogeneity (p=0.006, I 2 =69.2) (Figure 2B). Our outcomes showed that there was no significant correlation between TSP-1 and PFS/MFS (HR=1.35; 95%CI: 0.87-2.10; P=0.176). Likewise, subgroup analyses were stratified for the PFS/MFS group to identify the potential source of heterogeneity and other significant information. In ethnicity subgroup, high expression of TSP-1 was related to unfavorable PFS/MFS in Caucasians (HR = 1.80, 95%CI: 1.34–2.40; P＜0.001) (Figure 4A). Stratifying by the source of HR, high TSP-1 expression revealed a significant relationship with poor PFS/MFS, mainly in the report group (HR = 1.63, 95%CI: 1.24–2.15; P=0.001) but not in the SC group (Figure 4B). The subgroup analysis of cancer type indicated that TSP-1 have a statistically significant association with the breast cancer group (HR = 1.80, 95%CI: 1.20–2.71; P=0.004) and gynecologic cancer group (HR = 1.79, 95%CI: 1.18–2.71; P=0.006) (Figure 4C). when stratified by main pathological type, analysis in the adenocarcinoma group exhibited a significant correlation between up-regulated expression of TSP-1 and PFS/MFS (HR = 1.80, 95%CI: 1.20–2.71; P=0.004) (Figure 4D). Elevated TSP-1 predict poorer PFS/MFS in patients in the USA group (HR = 1.79, 95%CI: 1.18–2.71; P=0.006) (Figure 4E). The subgroup analysis in different assay methods had no obvious significance (Figure 4F). We analyzed tumor recurrence associated with overexpression of TSP-1 by DFS/RFS. Seven studies focused on DFS/RFS analysis, with a high degree of heterogeneity (P=0.001, I 2 =73.7) (Figure 2C).There was no correlation between high level of TSP-1 and poor DFS/RFS, (HR = 1.40, 95%CI: 0.77–2.53; P=0.271) by random effect model. Furthermore, through the subgroup analyses, we did not observe statistically significant outcomes (Figure S1). In summary, no relationship was found between DFS/RFS and TSP-1. Cumulative meta-analysis The main function of cumulative meta-analysis is reflecting the dynamic trend of the research results and evaluating the impact of each research on the comprehensive results. All the selected studies were sorted according to the year of publication. (Figure 5). The relationship between OS and TSP-1 was first statistically significant in 2001. In addition, the corresponding 95% CIs of OS became narrower with the continuous inclusion of studies, suggesting increasing estimated accuracy. On the contrary, as time goes on, the relationship of TSP-1 and DFS/RFS or PFS/MFS are no longer statistically significant, indicating growing controversy in recent research. Publication bias Egger’s test and Begg’s funnel plot were applied to indicate publication bias in the included studies (Figure S2). No obvious asymmetry was noticed in funnel plots and the P value of Egger’s test also revealed no obvious publication bias. (OS: P = 0.066; DFS/RFS: P =0.934; PFS/MFS: P =0.713). Sensitivity analysis In order to ensure the robustness of the above results and evaluate the stability of results, a sensitivity analysis was carried out by Stata 12.0 software. The analyzed result from a fixed model of OS and two random model of DFS/RFS and PFS/MFS demonstrated that no single study considerably influenced the pooled HRs or 95% CIs, suggesting that the results of the present meta-analysis are credible (Figure 6). Discussion TSP-1 is a homotrimeric protein which is a member of the thrombospondin gene family [3]. More and more evidence proved that the abnormal expression of TSP-1 is related to the clinical prognosis of cancer patients. Previous research has shown that TSP-1 plays an important role in inhibiting angiogenesis, anti-tumor activity and participating in tissue repair [8]. However, some studies deemed TSP-1 is connected with carcinogenesis [9]. The role of TSP-1 in various cancers has been widely researched, but the conclusions are not consistent. This is believed to be the first meta-analysis systematically analyzing the association between TSP-1 expression and clinical features of multiple cancers, which included 24 studies with a total of 2379 patients. Our analysis showed that the pooled HR was 1.40, indicating that the elevated TSP-1 was significantly associated with lower OS (P＜0.001). The pooled HR of PFS/MFS analysis and DFS/RFS analysis was 1.35 (P=0.176) and 1.40 (P=0.271) respectively, which demonstrated the consistency of the results, but they were not statistically significant. Some studies have shown that TSP-1 promotes the development of prostate cancer, and this property is stronger than its anti-angiogenic properties which are mediated by its binding to the CD36 receptor [45, 46]. In addition, they found that TSP-1 promotes cell migration by mediating TRPV3 and, in patients, TSP-1 mRNA level in tumor tissue was significantly associated with PSA relapse. Furthermore, there could be a vicious circle in which TSP-1 inhibits angiogenesis and thus increases hypoxia which induces TSP-1 expression in return to speed up cell migration [10].All the studies consistent with the results from our analysis. Detection of TSP-1 can identify subgroups of high-risk patients with poor outcomes. In addition, Kang et al found Sphingosylphosphorylcholine induces TSP-1 secretion which might play an important role in epithelial-mesenchymal transition since migration and invasion are the key indicators of epithelial-mesenchymal transition [47]. Then, the migration and invasion of breast cancer were significantly interrupted when they knocked down TSP-1. Moreover, in breast cancer patients, the high expression of TSP-1 was significantly associated with poor RFS and MFS [10, 47, 48]. We used subgroup analyses to find out the influence of nationality, dominant ethnicity, main pathological type, disease type, assay method and source of HR on the relationship between TSP-1 and patient prognosis. With regard to the ethnic subgroup analysis, we made a distinction between Asians and Caucasians to clarify the impacts of different genetic backgrounds on the results. Interestingly, the analysis showed a significant association between the high expression of TSP-1 and OS/PFS/MFS (HR = 1.40, 95%CI: 0.77–2.53) (HR = 1.80, 95%CI: 1.34–2.40; P＜0.001) in Caucasians, but not in Asians. The reason may be attributed to differences in genetic background and environmental exposure. Secondly, OS and PFS/MFS of breast cancer and gynecological cancer in disease type subgroup were remarkable poor. Campone et al deem TSP1 as bad prognostic markers by Kaplan-Meier method and immunohistochemistry (IHC) in triple-negative breast cancers [24]. Some studies have shown that TSP-1 promotes the invasiveness of melanoma which declared TSP-1 is a poor prognostic marker [49]. Nevertheless, other research argued that TSP-1 could significantly inhibit the cell viability of Retinoblastoma cells both in vitro and in vivo [50]. To sum up, the prognostic value of TSP-1 may be different in various cancers. However, more studies are required to confirm the clinical significance of TSP-1 in many samples. Furthermore, the OS (HR=1.48; 95%CI: 1.18~1.87; P=0.001) and PFS/MFS (HR = 1.63, 95%CI: 1.24–2.15; P=0.001) was significantly worse in “reported” group but not in the SC group. Throughout this literature, 13 of the 24 studies with survival information did not provide the HRs, so we could only gather the data from Kaplan-Meier curves. There may be some slight errors between the accurate data and the estimated HRs and their 95% CIs from the Kaplan-Meier curves, leading to unreliable results. In other subgroups, we did not find any statistical significance. It should be noted that heterogeneity is a potential and critical issue that should not be ignored when discussing the results of Meta-analysis. We believe that the mild heterogeneity observed in OS is acceptable. Moreover, the heterogeneity of PFS/DFS was greatly reduced by subgroup analysis. Sensitivity analysis was performed to assess the reliability of results which revealed that the pooled HR did not significantly change by omitting any individual studies, meaning that the results of this meta-analysis are credible. no evidence of publication bias was noted. Although this study provided a comprehensive meta-analysis for the prognostic role of TSP-1 in multiple cancers, several limitations do exist. First, Heterogeneity was noted among the selected studies. The existence of heterogeneity may be contributing to the unique characteristics, such as the nationality, dominant ethnicity, the main pathological type, disease type, assay method, source of HR and critical values of TSP-1 expression. Second, it was difficult to determine a standard expression cutoff value because of different cancers, varied assay method and diverse detected sample in the included studies. This could result in bias in the effectiveness of TSP-1 as a prognostic factor. Most studies have established a median expression, IHC intensities or a scoring system as the cutoff value. Therefore, pooled outcomes may be greater or lower than the actual value and cause bias in the results. What's more, the relatively small number of studies on PFS/MFS and DFS/RFS is a limitation, further studies with more selected data and enrolled patients are needed. As mentioned above, the data in SC group extracted through Kaplan-Meier curves may not be accurate. Finally, only English articles are accepted in this article, which may cause deviations in the results. These limitations should be addressed in further research and be considered when drawing conclusions. In conclusion, TSP-1 might serve as an effective index in evaluating the progress and prognosis of multiple cancers, especially in breast and gynecologic cancer, and may be utilized to improve targeted therapies. In order to accurately evaluate the role of TSP-1 as a prognostic factor, more clinical studies are required before TSP-1 is applied, especially for single type of cancer. Conclusion In this paper, we firstly evaluated whether TSP-1 was an accurate prognostic prediction for multiple cancers. Our data provided convincing evidence that high expression of TSP-1 was associated with adverse cancer prognosis. However, further in-depth and larger-scale studies are needed to support our results. Abbreviations TSP-1: Thrombospondin-1; HRs: hazard ratio; CIs: confidence intervals; OS: overall survival; PFS: progression-free survival; MFS: metastasis-free survival; DFS: disease-free survival; RFS: recurrence-free survival. Declarations Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this manuscript. Competing interests The authors declare that they have no competing interests. Funding The study was supported by National Natural Science Foundation of China (grant numbers 81672532), Jiangsu Province’s Key Provincial Talents Program (ZDRCA2016012), Natural Science Foundation of Jiangsu Province (NO.BK20191077) and Postgraduate Research & Practice Innovation Program of Jiangsu Province (grant number KYCX18-1488). Authors' contributions Study design: LC and LJ. Acquisition, analysis and interpretation of data: SSJ, DHY and YT. 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You J, Zhang X, Zhang J, Chen H, Liu Y, Sun L. Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance. Zhongguo Fei Ai Za Zhi. 2000; 3(3):175-179. Yao L, Zhao YL, Itoh S, Wada S, Yue L, Furuta I. Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival. Oral Oncol. 2000; 36(6):539-544. Yang S, Guo LJ, Tang XF, Tan K, Gong RG, Li A, Yu T, Gao QH, Xuan M, Wen YM et al . The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis. Int J Oral Maxillofac Surg. 2010; 39(1):29-35. Wada H, Nagano H, Yamamoto H, Yang Y, Kondo M, Ota H, Nakamura M, Yoshioka S, Kato H, Damdinsuren B et al . Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int. 2006; 26(4):414-423. Maeda K, Nishiguchi Y, Kang SM, Yashiro M, Onoda N, Sawada T, Ishikawa T, Hirakawa K. Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer. Oncol Rep. 2001; 8(4):763-766. Kodama J, Hashimoto I, Seki N, Hongo A, Yoshinouchi M, Okuda H, Kudo T. Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis. Clin Cancer Res. 2001; 7(9):2826-2831. Nakamura Y, Miyata Y, Takehara K, Asai A, Mitsunari K, Araki K, Matsuo T, Ohba K, Sakai H. The Pathological Significance and Prognostic Roles of Thrombospondin-1, and -2, and 4N1K-peptide in Bladder Cancer. Anticancer Res. 2019; 39(5):2317-2324. Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC et al . Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis. Clin Cancer Res. 2017; 23(9):2335-2345. Fontana A, Filleur S, Guglielmi J, Frappart L, Bruno-Bossio G, Boissier S, Cabon F, Clezardin P. Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo. Int J Cancer. 2005; 116(5):686-691. Dawson DW, Volpert OV, Pearce SF, Schneider AJ, Silverstein RL, Henkin J, Bouck NP. Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. Mol Pharmacol. 1999; 55(2):332-338. Dawson DW, Pearce SF, Zhong R, Silverstein RL, Frazier WA, Bouck NP. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol. 1997; 138(3):707-717. Kang JH, Kim HJ, Park MK, Lee CH. Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2. Biomol Ther (Seoul). 2017; 25(6):625-633. Sid B, Langlois B, Sartelet H, Bellon G, Dedieu S, Martiny L. Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity. Int J Biochem Cell Biol. 2008; 40(9):1890-1900. Jayachandran A, Anaka M, Prithviraj P, Hudson C, McKeown SJ, Lo PH, Vella LJ, Goding CR, Cebon J, Behren A. Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma. Oncotarget. 2014; 5(14):5782-5797. Chen P, Yu N, Zhang Z, Zhang P, Yang Y, Wu N, Xu L, Zhang J, Ge J, Yu K et al . Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair. Oncotarget. 2016; 7(5):6105-6120. Additional File Legends Figure S1: Forest plots of merged analyses for DFS/RFS associated with TSP-1 expression. Figure S2: Begg’s funnel plots of the publication bias. Tables Table.1 Main characteristics of studies included in the meta-analysis First author, Publication year Case nationality Male(%) Dominant ethnicity Main pathological type Disease type Detected sample Outcome measures Source of HR Maximum months of follow-up Assay method Nakamura et al, 2019 Japan 0.79 Asian Urothelial carcinoma Bladder cancer Tissue PFS Reported 95 IHC Tzeng et al, 2016 China N/A Asian Squamous cell carcinoma Esophagus cancer Tissue PFS SC 228 IHC Rouanne et al, 2016 France 0.67 Caucasian Adenocarcinoma Lung cancer Serum OS/DFS Reported 34 ELISA Teraoku et al, 2016 Japan 0.35 Asian Adenocarcinoma Colon cancer Tissue OS/DFS SC 168 IHC Campone et al, 2015 France N/A Caucasian Adenocarcinoma Breast cancer Tissue OS SC 279 IHC Eto et al, 2015 Japan 0.8 Asian Adenocarcinoma Gastric cancer Tissue OS SC 60 IHC Yao et al, 2014 China 0.68 Asian Non-Small Cell Lung Cancer Lung cancer Tissue OS/DFS Reported 60 ELISA Sharma et al, 2013 India 92.5 Asian Hepatocellular Carcinoma Liver cancer Tissue OS Reported 33 PCR Pectasides et al, 2012 Greece 0 Caucasian Adenocarcinoma Breast cancer Tissue OS/PFS Reported 45 PCR Nakao et al, 2011 Japan 0.8 Asian Adenocarcinoma Gastric cancer Tissue OS SC 50 IHC Zhou et al, 2009 China 0.73 Asian Squamous cell carcinoma esophagus cancer Tissue OS Reported 50 IHC Randall et al, 2009 USA N/A Caucasian Squamous cell carcinoma Cervical cancer Tissue OS/PFS Reported 184.8 IHC Yang et al, 2009 China 0.51 Asian mucoepidermoid carcinoma Oral cancer Tissue DFS SC 60 IHC Secord et al, 2007 USA 0 Caucasian Epithelial cancer Ovarian cancer Tissue OS/PFS Reported 110 Immunoblot analysis Wada et al, 2006 Japan 0.75 Asian Hepatocellular Carcinoma Liver cancer Tissue DFS SC 60 IHC Sutton et al, 2005 UK 0.67 Caucasian Adenocarcinoma Colon cancer Tissue OS Reported 60 Dextran polymer conjugate wwo-step visualization system Fontana et al, 2005 France N/A Caucasian Adenocarcinoma Breast cancer Tissue PFS SC 160 IHC Poon et al, 2004 China 0.82 Asian Hepatocellular Carcinoma Liver cancer Tissue OS SC 38 IHC Aishima et al, 2002 Japan N/A Asian Intrahepatic Cholangiocarcinoma Liver cancer Tissue OS SC 120 IHC Maeda et al, 2001 Japan 0.63 Asian Adenocarcinoma Colon cancer Tissue DFS Reported 60 IHC Straume et al, 2001 Norway N/A Caucasian Melanomas Skin cancer Tissue OS SC 210 IHC Kodama et al, 2001 Japan N/A Asian Squamous cell carcinoma Cervical cancer Tissue DFS Reported 59 PCR You et al, 2000 China 0.57 Asian Squamous cell carcinoma Lung cancer Tissue OS SC 120 IHC Yao et al, 2000 Japan N/A Asian Squamous cell carcinoma Oral cancer Tissue OS SC 60 IHC OS, overall survival; DFS, disease-free survival; PFS, progression-free survival; SC: survival curve; IHC, Immunohistochemistry; PCR, polymerase chain reaction; ELISA, enzyme linked immunosorbent assay; N/A, not available. Table.2 HRs and 95% CIs of cancer prognosis and progression associated with TSP-1 expression in included studies First author, Publication year Cut-off value Number of cases OS DFS/RFS PFS/MFS High expression low expression Total HR (95% CI) P Value HR (95% CI) P Value HR (95% CI) P Value Nakamura et al, 2019 10% of the cells were positive 86 120 206 N/A N/A N/A N/A 1.11 (0.56-2.19) 0.774 Tzeng et al, 2016 value =40 76 107 183 N/A N/A N/A N/A 0.61 (0.38-0.99) <0.001 Rouanne et al, 2016 Median N/A N/A 171 0.15 (0.03–0.89) 0.04 0.39 (0.10–1.45) 0.23 N/A N/A Teraoku et al, 2016 score=3 35 59 94 2.61 (1.00-8.16) <0.01 0.63 (0.38-1.06) 0.06 N/A N/A Campone et al, 2015 positive 19 14 33 0.86 (0.08-8.85) 0.0364 N/A N/A N/A N/A Eto et al, 2015 10% of the cells were positive 17 48 65 0.53 (0.24-1.18) <0.05 N/A N/A N/A N/A Yao et al, 2014 Median N/A N/A 68 1.52 (0.91–3.14) 0.088 1.62 (0.91–3.76) 0.112 N/A N/A Sharma et al, 2013 Median N/A N/A 67 0.982 (0.541-1.784) 0.953 N/A N/A N/A N/A Pectasides et al, 2012 Median 60 60 120 1.84 (1.11-3.05) 0.018 N/A N/A 1.73 (1.11-2.69) 0.016 Nakao et al, 2011 30% of the cells were positive 17 48 65 0.54 (0.26-1.14) <0.01 N/A N/A N/A N/A Zhou et al, 2009 10 percentile 72 8 80 0.41 (0.07-2.38) 0.042 N/A N/A N/A N/A Randall et al, 2009 score=3 112 54 166 1.44 (0.70–2.75) 0.32 N/A N/A 1.30 (0.67–2.54) 0.44 Yang et al, 2009 moderate staining 25 45 70 N/A N/A 0.77 (0.18-3.42) 0.012 N/A N/A Secord et al, 2007 Median 32 35 67 1.93 (1.12-3.32) 0.018 N/A N/A 2.19 (1.29-3.71) 0.004 Wada et al, 2006 score=2 9 51 60 N/A N/A 2.85 (1.05-7.72) 0.689 N/A N/A Sutton et al, 2005 Median 45 137 182 1.82 (1.0-3.1) 0.01 N/A N/A N/A N/A Fontana et al, 2005 positive 54 23 77 N/A N/A N/A N/A 2.25 (0.81-6.27) 0.07 Poon et al, 2004 0.75 15 45 60 2.49 (0.63-9.86) 0.014 N/A N/A N/A N/A Aishima et al, 2002 50% of the cells were positive 34 33 67 1.39 (0.70-2.78) 0.08 N/A N/A N/A N/A Maeda et al, 2001 positive 89 61 150 N/A N/A 2.37 (1.41-3.83) 0.03 N/A N/A Straume et al, 2001 moderate staining 77 104 181 2.07 (1.27-3.40) 0.0001 N/A N/A N/A N/A Kodama et al, 2001 positive 31 23 54 N/A N/A 3.16 (1.25-7.98) 0.015 N/A N/A You et al, 2000 5% of the cells were positive 29 10 39 1.49 (0.48-4.58) 0.0163 N/A N/A N/A N/A Yao et al, 2000 moderate staining 22 32 54 0.81 (0.14-4.58) 0.045 N/A N/A N/A N/A OS, overall survival; DFS, disease-free survival; MFS, metastasis-free survival; RFS, recurrence-free survival; PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; N/A, not available. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-20184","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":689562,"identity":"ced95e7d-3edf-491f-9746-e069497e63f4","order_by":0,"name":"Shengjie Sun","email":"","orcid":"","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shengjie","middleName":"","lastName":"Sun","suffix":""},{"id":689563,"identity":"2b0b8d65-10a7-47c7-a608-8b93f32d2b7b","order_by":1,"name":"Huiyu Dong","email":"","orcid":"","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Huiyu","middleName":"","lastName":"Dong","suffix":""},{"id":689564,"identity":"4d9a105e-a4ca-4c32-bbd5-aae6260f0141","order_by":2,"name":"Tao Yan","email":"","orcid":"","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Tao","middleName":"","lastName":"Yan","suffix":""},{"id":689565,"identity":"eccc54bd-8924-47ab-9f22-ee27c4e9b1a7","order_by":3,"name":"Junchen Li","email":"","orcid":"","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Junchen","middleName":"","lastName":"Li","suffix":""},{"id":689566,"identity":"b0ab87b4-09b4-4bbf-9be1-c4063b78ff8b","order_by":4,"name":"Bianjiang Liu","email":"","orcid":"","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Bianjiang","middleName":"","lastName":"Liu","suffix":""},{"id":689567,"identity":"40d20700-572d-46c6-91ec-59e1a94b0db2","order_by":5,"name":"Pengfei Shao","email":"","orcid":"","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Pengfei","middleName":"","lastName":"Shao","suffix":""},{"id":689568,"identity":"bf41d80f-a418-41e1-a21b-a89c77c42b6a","order_by":6,"name":"Jie Li","email":"","orcid":"","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jie","middleName":"","lastName":"Li","suffix":""},{"id":689569,"identity":"ace7a87f-7de7-466f-908b-38901b33969a","order_by":7,"name":"Chao Liang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAxUlEQVRIiWNgGAWjYBACPgh1gIeBgfnAgQ8/iNDChtDClnhwZg8JWoCYx/gwBxsxWtgPsG74UXNHxpy958NhBh4GeX6xAwS08CSw3ew59ozHsufshsMFFgyGM2cnENAiwcB2g7fhMI/BjdwNh2fwMCQY3CZCy82/IC333zw4zMNGpJbbEFt4GIjUAvTLbZljQC1n0gyAgSxB2C/87AfYbr6pOWxvcPzw4w8fftjI80sT0ALU9AGZJ0FI+SgYBaNgFIwCYgAASxZEKDETfKAAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-4716-8009","institution":"The First Affiliated Hospital of Nanjing Medical University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Chao","middleName":"","lastName":"Liang","suffix":""}],"badges":[],"createdAt":"2020-03-30 11:06:29","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.3.rs-20184/v3","doiUrl":"https://doi.org/10.21203/rs.3.rs-20184/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12881-020-01073-3","type":"published","date":"2020-06-29T12:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":1366978,"identity":"35a82e30-5886-4c94-93dc-e19dc7779e2e","added_by":"auto","created_at":"2020-06-19 05:12:02","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":40029,"visible":true,"origin":"","legend":"Selection process of studies for meta-analysis","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/1.jpg"},{"id":1366979,"identity":"53b29086-9b9e-468a-b58b-7243c04bfe0d","added_by":"auto","created_at":"2020-06-19 05:12:02","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":65638,"visible":true,"origin":"","legend":"Forest plots of merged analyses for survival associated with TSP-1 expression. (A) Forest plot to assess the OS analysis; (B) Forest plots for the PFS/MFS analysis; (C) Forest plots of the DFS/RFS analysis. Abbreviation: OS, overall survival; PFS, progression-free survival; MFS, metastasis-free survival; RFS, recurrence-free survival; DFS, disease-free survival; HR, Hazard ratio","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/2.jpg"},{"id":1366980,"identity":"820f2750-4aa5-4bd2-a38b-fe2efb8b2047","added_by":"auto","created_at":"2020-06-19 05:12:02","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":145071,"visible":true,"origin":"","legend":"Forest plots of merged analyses for OS associated with TSP-1 expression. (A) Forest plots for the subgroup analysis in different ethnicities; (B) Forest plots for the subgroup analysis in different source of HR; (C) Forest plots for the subgroup analysis in different disease types; (D) Forest plots for the subgroup analysis in different pathological types; (E) Forest plots for the subgroup analysis in different nationalities; (F) Forest plots for the subgroup analysis in different assay methods. Abbreviations: HR, Hazard ratio; SC: survival curve; PCR, polymerase chain reaction; IHC, immunohistochemistry; ELISA, enzyme linked immunosorbent assay.","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/3.jpg"},{"id":1366981,"identity":"42529a9d-8f11-47e0-ab95-9ea848d0fc0f","added_by":"auto","created_at":"2020-06-19 05:12:02","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":93471,"visible":true,"origin":"","legend":"Forest plots of merged analyses for PFS/MFS associated with TSP-1 expression. (A) Forest plots for the subgroup analysis in different ethnicities; (B) Forest plots for the subgroup analysis in different source of HR; (C) Forest plots for the subgroup analysis in different disease types; (D) Forest plots for the subgroup analysis in different pathological types; (E) Forest plots for the subgroup analysis in different nationalities; (F) Forest plots for the subgroup analysis in different assay methods. Abbreviations: HR, Hazard ratio; SC: survival curve; PCR, polymerase chain reaction; IHC, immunohistochemistry.","description":"","filename":"4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/4.jpg"},{"id":1366982,"identity":"b1f0f2cb-e905-461a-90eb-33f028cfc483","added_by":"auto","created_at":"2020-06-19 05:12:02","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":54793,"visible":true,"origin":"","legend":"Cumulative meta-analyses for survival associated with TSP-1 expression. (A) Cumulative meta-analysis of OS; (B) Cumulative meta-analysis of PFS/MFS; (C) Cumulative meta-analysis of DFS/RFS. Abbreviation: OS, overall survival; PFS, progression-free survival; MFS, metastasis-free survival; RFS, recurrence-free survival; DFS, disease-free survival; HR, hazard ratio","description":"","filename":"5.jpg","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/5.jpg"},{"id":1366983,"identity":"4e286a6b-16bb-42e0-9b29-e1544da36900","added_by":"auto","created_at":"2020-06-19 05:12:03","extension":"jpg","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":35620,"visible":true,"origin":"","legend":"Sensitivity analysis of each included study. (A) Sensitivity analysis of OS for individual studies. (B) Sensitivity analysis of PFS/MFS for individual studies. (C) Sensitivity analysis of DFS/RFS for individual studies. Abbreviations: OS, overall survival; PFS, progression-free survival; MFS, metastasis-free survival; RFS, recurrence-free survival; DFS, disease-free survival.","description":"","filename":"6.jpg","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/6.jpg"},{"id":13542578,"identity":"8351a30c-d858-4f3c-977a-287aa2132120","added_by":"auto","created_at":"2021-09-17 01:55:02","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":630202,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/50c39dc5-7770-48ae-bc83-872571614c44.pdf"},{"id":1366985,"identity":"37e56289-f060-4002-995d-f3fda1b6196e","added_by":"auto","created_at":"2020-06-19 05:12:03","extension":"pptx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":1527888,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile1.pptx","url":"https://assets-eu.researchsquare.com/files/rs-20184/v3/Additionalfile1.pptx"}],"financialInterests":"","formattedTitle":"Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis","fulltext":[{"header":"Background","content":"\u003cp\u003eThrombospondin-1 (TSP-1) is one of the thrombospondin gene family, which be composed of five matricellular proteins includes TSP-1, -2, -3, -4, and -5 [1, 2]. Thrombospondin gene family plays a role in extensive physiological and pathological processes, including development, angiogenesis, inflammation and neoplasia [3]. This TSP family interact with a variety of membrane proteins on the cell surface, such as proteoglycans, integrins, CD36 and CD47 [4, 5]. Thus, during tissue development and remodeling, TSP family control cellular phenotype and extracellular matrix structure [3].\u003c/p\u003e\n\u003cp\u003eTSP-1 is a multifunctional matrix glycoprotein which is synthesized and secreted by platelets, endothelial cells and smooth muscle cells. Under the transmission microscope, TSP-1 is composed of three identical peptide chains, each showing a spherical amino at one end and a spherical carboxyl at the other end, connected by a slender rod-like arm in the middle [6]. Because of multiple functional domains, TSP-1 can mediate the interaction between cell and cell, cell and extracellular matrix. Therefore, TSP-1 is a kind of glycoprotein with a wide range of biological effects, such as activating transforming growth factor-\u0026beta;, inhibiting angiogenesis, anti-tumor activity, participating in tissue repair and so on [7, 8]. TSP-1 was originally found in platelets, but now it has been shown to play an important role in carcinogenesis [9, 10]. Besides its direct role in regulating the behavior of tumor cells, TSP-1 also shows function in tumor vessels [11]. Taken together, TSP-1 can regulate the growth, adhesion and migration of tumor cells [12].\u003c/p\u003e\n\u003cp\u003eThe function of TSP 1 remains disputable in angiogenesis and tumor progression. In some cancers, TSP 1 has been deemed to be an inhibitor of both processes [13-15], while in others, it has been considered a stimulator [16-18]. Some research concluded that the actual function of TSP 1 was organ specific [19].\u003c/p\u003e\n\u003cp\u003eTo address this issue, we performed meta-analysis to comprehensively assess the overall risk of TSP-1 for survival in patients with various types of cancers. Furthermore, we attempt to evaluate the value of TSP-1 as a prognostic marker in the aspect of clinical features and statistics.\u003c/p\u003e"},{"header":"Methods","content":"\u003ch3\u003eSearch strategy\u003c/h3\u003e\n\u003cp\u003eOriginal studies aimed to analyze the predictive value of TSP-1 in multiple human malignant neoplasms. PubMed, Web of Science, Cochrane Library and Embase were searched up from inception to December 14, 2019 using the following key words: \u0026ldquo;Thrombospondin 1\u0026rdquo;, \u0026ldquo;Neoplasm\u0026rdquo;, \u0026ldquo;prognosis\u0026rdquo;, \u0026ldquo;survival\u0026rdquo;, \u0026ldquo;recurrence\u0026rdquo;, \u0026ldquo;death\u0026rdquo;, \u0026ldquo;incidence\u0026rdquo;, \u0026ldquo;mortality\u0026rdquo;. The search strategy used a combination of Medical Subject Headings and thesaurus terms.\u003c/p\u003e\n\u003ch3\u003eInclusion criteria and exclusion criteria\u003c/h3\u003e\n\u003cp\u003eWe considered articles were considered qualified when they met the following criteria: (1) patients diagnosed with cancers by using pathological methods (2) studies focusing on the relationship between TSP-1 expression and prognosis, (3) survival outcomes with 95% confidence intervals (CIs) and hazard ratios (HRs) that could be extracted directly or indirectly. Excluding criteria were as follows: (1) Not a human study; (2) Not original articles; (3) Unrelated to TSP-1; (4) No clinical parameters; (5) Unrelated to malignant tumor; (6) Not related to prognosis or survival; (7) Insufficient survival data; (8) Overlapping data.\u003c/p\u003e\n\u003ch3\u003eQuality assessment\u003c/h3\u003e\n\u003cp\u003eQuality assessment of the included studies was conducted independently by three researchists (SS, HD and TY) to rule out any discrepancy. Studies for\u0026nbsp;inclusion include the following criteria: (1) the study country and population; (2) definition of study design (3) the samples and pathology information; (4) defiition of measurement of TSP-1; (5) the clinical outcomes and follow-up duration.\u003c/p\u003e\n\u003ch3\u003eData extraction\u003c/h3\u003e\n\u003cp\u003eAll relevant studies were identified by two independent reviewers (TY and HD), and any disagreements were reassessed by a third reviewer (SS). The data elements include the following information: (1) publication year and first author\u0026rsquo;s name; (2) nationality, dominant ethnicity, number of patients, sample type, and main type of pathology; (3) Assay method, follow-up time; (4) TSP-1 expression levels and cut-off values; (5) HRs related to elevated TSP-1 expression for overall survival (OS), recurrence-free survival (RFS), and disease-free survival (DFS). Those indirectly reported HRs and 95% CIs were calculated using graphical survival plots.\u003c/p\u003e\n\u003ch3\u003eStatistical methods\u003c/h3\u003e\n\u003cp\u003eA random or fixed model was selected according the heterogeneity which was measured by the Q statistics and Higgins I-squared statistic (I\u003csup\u003e2\u003c/sup\u003e). If P \u0026lt; 0.10 or I\u003csup\u003e2\u003c/sup\u003e \u0026gt; 50%, a random-effects model was applied and subgroup ana lyses was carried out to fine the source of heterogeneity; otherwise, a fixed-effects model was adopted [20]. Publication bias was assessed by Egger\u0026rsquo;s test and Begg\u0026rsquo;s funnel plot [21]. To examine the stability and dependability of the overall outcomes, sensitivity analyses were performed by excluding one single study one by one and recalculating their HRs. All P-values were calculated using a two-sided test. We consider P\u0026lt;0.05 as statistically significant. All statistical analyses were conducted by using Excel software 2016 and Stata version 12.0.\u003c/p\u003e"},{"header":"Results","content":"\u003ch3\u003eStudy selection\u003c/h3\u003e\n\u003cp\u003eThe flow chart of study selection process was depicted in Figure 1. A total of 251 studies were identified from online databases, including PubMed, Cochrane Library, Web of Science and Embase. Based on screening of titles and abstracts, 54 studies were selected for further investigation according to following criteria: repetitive articles, not a human study, not original articles, no clinical parameters, unrelated to TSP-1, unrelated to malignant neoplasms and unrelated to prognosis or survival. Of these 54 studies, 30 were excluded due to insufficient survival data and overlapping data. Ultimately, 24 articles were included for further analysis.\u003c/p\u003e\n\u003ch3\u003eStudy characteristics\u003c/h3\u003e\n\u003cp\u003eThe major characteristics of the eligible data were summarized in Table 1. We collected basic data on 24 articles published between 2000 and 2019. The meta-analysis included 2379 participants from different regions of the United States, France, Japan, China, India, Greece, the United Kingdom and Norway, including tumors such as breast cancer, liver cancer, ovarian cancer, esophagus cancer, lung cancer, gastric cancer, colon cancer, skin cancer, cervical cancer, oral cancer and bladder cancer.\u003c/p\u003e\n\u003cp\u003eThe expression of TSP-1 was measured by Immunohistochemical staining (IHC) in the most of studies. Besides, Quantitative real-time polymerase chain reaction (qRT-PCR) assay and enzyme linked immunosorbent assay (ELISA) was applied to detect TSP-1 in 3 and 2 studies, respectively, and immunoblot analysis and a standard Dextran Polymer Conjugate Two-step Visualization System Envision was applied in 1 study each. The data of HR and 95% CI was extracted from survival curves or literature reports. In all these studies, 17 studies researched OS [17, 22-37], 7 studies investigated DFS/RFS [22, 23, 26, 38-41] and 6 studies focused on progression-free survival (PFS)/ metastasis-free survival (MFS) [28, 31, 32, 42-44] (Table 2).\u003c/p\u003e\n\u003ch3\u003eOS associated with TSP-1 expression\u003c/h3\u003e\n\u003cp\u003eBecause of the mild heterogeneity (p=0.016, I\u003csup\u003e2\u003c/sup\u003e=47.3), the fixed effect model was used for data analysis. The results showed that high level of TSP-1 indicated poor OS, (HR=1.40; 95% CI: 1.17~1.68) and the effect was statistically significant (P＜0.001) (Figure 2A). In order to analyze the source of heterogeneity, we did subgroup analyses according to nationality, dominant ethnicity, main pathological type, disease type, assay method and source of HR. When stratified by ethnicity, we found that the high level of TSP-1 was significantly correlated with the OS of Caucasians (HR=1.74; 95%CI: 1.37-2.22; P＜0.001), while among Asians, there was no significant correlation (HR=1.07, 95%CI: 0.82-1.40; P=0.629) (Figure 3A). In the source of HR analysis, the OS of \u0026ldquo;reported\u0026rdquo; group was significantly worse(HR=1.48; 95%CI: 1.18~1.87; P=0.001), while the OS of the other group was also worse, however, with no statistical significance(HR=1.29; 95%CI: 0.97~1.171; P=0.081) (Figure 3B). According to the subgroup analysis of disease type, the pooled HR of breast cancer was 1.78(95%CI: 1.09~2.92; P=0.022) (I\u003csup\u003e2\u003c/sup\u003e=0.0%, P=0.536), and the pooled HR of gynecological cancer was 1.72(95%CI:1.13-2.64; P=0.012)(I\u003csup\u003e2\u003c/sup\u003e=0.0%, P=0.511), with no heterogeneity (Figure 3C). Finally, there was a significant relationship between elevated TSP-1 and poor OS in Americans. (HR=1.72; 95%CI: 1.13-2.64; P=0.012) (Figure 3E). Other kinds of diseases had no obvious significance (Figure 3D, 3F).\u003c/p\u003e\n\u003ch3\u003ePFS/MFS and DFS/RFS associated with TSP-1 expression\u003c/h3\u003e\n\u003cp\u003eSix studies were included in the PFS/MFS analysis, in which a random-effect model was used because of the significant heterogeneity (p=0.006, I\u003csup\u003e2\u003c/sup\u003e=69.2) (Figure 2B). Our outcomes showed that there was no significant correlation between TSP-1 and PFS/MFS (HR=1.35; 95%CI: 0.87-2.10; P=0.176). Likewise, subgroup analyses were stratified for the PFS/MFS group to identify the potential source of heterogeneity and other significant information. In ethnicity subgroup, high expression of TSP-1 was related to unfavorable PFS/MFS in Caucasians (HR = 1.80, 95%CI: 1.34\u0026ndash;2.40; P＜0.001) (Figure 4A). Stratifying by the source of HR, high TSP-1 expression revealed a significant relationship with poor PFS/MFS, mainly in the report group (HR = 1.63, 95%CI: 1.24\u0026ndash;2.15; P=0.001) but not in the SC group (Figure 4B). The subgroup analysis of cancer type indicated that TSP-1 have a statistically significant association with the breast cancer group (HR = 1.80, 95%CI: 1.20\u0026ndash;2.71; P=0.004) and gynecologic cancer group (HR = 1.79, 95%CI: 1.18\u0026ndash;2.71; P=0.006) (Figure 4C). when stratified by main pathological type, analysis in the adenocarcinoma group exhibited a significant correlation between up-regulated expression of TSP-1 and PFS/MFS (HR = 1.80, 95%CI: 1.20\u0026ndash;2.71; P=0.004) (Figure 4D). Elevated TSP-1 predict poorer PFS/MFS in patients in the USA group (HR = 1.79, 95%CI: 1.18\u0026ndash;2.71; P=0.006) (Figure 4E). The subgroup analysis in different assay methods had no obvious significance (Figure 4F).\u003c/p\u003e\n\u003cp\u003eWe analyzed tumor recurrence associated with overexpression of TSP-1 by DFS/RFS. Seven studies focused on DFS/RFS analysis, with a high degree of heterogeneity (P=0.001, I\u003csup\u003e2\u003c/sup\u003e=73.7) (Figure 2C).There was no correlation between high level of TSP-1 and poor DFS/RFS, (HR = 1.40, 95%CI: 0.77\u0026ndash;2.53; P=0.271) by random effect model. Furthermore, through the subgroup analyses, we did not observe statistically significant outcomes (Figure S1). In summary, no relationship was found between DFS/RFS and TSP-1.\u003c/p\u003e\n\u003ch3\u003eCumulative meta-analysis\u003c/h3\u003e\n\u003cp\u003eThe main function of cumulative meta-analysis is reflecting the dynamic trend of the research results and evaluating the impact of each research on the comprehensive results. All the selected studies were sorted according to the year of publication. (Figure 5). The relationship between OS and TSP-1 was first statistically significant in 2001. In addition, the corresponding 95% CIs of OS became narrower with the continuous inclusion of studies, suggesting increasing estimated accuracy. On the contrary, as time goes on, the relationship of TSP-1 and DFS/RFS or PFS/MFS are no longer statistically significant, indicating growing controversy in recent research.\u003c/p\u003e\n\u003ch3\u003ePublication bias\u003c/h3\u003e\n\u003cp\u003eEgger\u0026rsquo;s test and Begg\u0026rsquo;s funnel plot were applied to indicate publication bias in the included studies (Figure S2). No obvious asymmetry was noticed in funnel plots and the P value of Egger\u0026rsquo;s test also revealed no obvious publication bias. (OS: P = 0.066; DFS/RFS: P =0.934; PFS/MFS: P =0.713).\u003c/p\u003e\n\u003ch3\u003eSensitivity analysis\u003c/h3\u003e\n\u003cp\u003eIn order to ensure the robustness of the above results and evaluate the stability of results, a sensitivity analysis was carried out by Stata 12.0 software. The analyzed result from a fixed model of OS and two random model of DFS/RFS and PFS/MFS demonstrated that no single study considerably influenced the pooled HRs or 95% CIs, suggesting that the results of the present meta-analysis are credible (Figure 6).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eTSP-1 is a homotrimeric protein which is a member of the thrombospondin gene family [3]. More and more evidence proved that the abnormal expression of TSP-1 is related to the clinical prognosis of cancer patients. Previous research has shown that TSP-1 plays an important role in inhibiting angiogenesis, anti-tumor activity and participating in tissue repair [8]. However, some studies deemed TSP-1 is connected with carcinogenesis [9]. The role of TSP-1 in various cancers has been widely researched, but the conclusions are not consistent.\u003c/p\u003e\n\u003cp\u003eThis is believed to be the first meta-analysis systematically analyzing the association between TSP-1 expression and clinical features of multiple cancers, which included 24 studies with a total of 2379 patients.\u003c/p\u003e\n\u003cp\u003eOur analysis showed that the pooled HR was 1.40, indicating that the elevated TSP-1 was significantly associated with lower OS (P＜0.001). The pooled HR of PFS/MFS analysis and DFS/RFS analysis was 1.35 (P=0.176) and 1.40 (P=0.271) respectively, which demonstrated the consistency of the results, but they were not statistically significant.\u003c/p\u003e\n\u003cp\u003eSome studies have shown that TSP-1 promotes the development of prostate cancer, and this property is stronger than its anti-angiogenic properties which are mediated by its binding to the CD36 receptor [45, 46]. In addition, they found that TSP-1 promotes cell migration by mediating TRPV3 and, in patients, TSP-1 mRNA level in tumor tissue was significantly associated with PSA relapse. Furthermore, there could be a vicious circle in which TSP-1 inhibits angiogenesis and thus increases hypoxia which induces TSP-1 expression in return to speed up cell migration [10].All the studies consistent with the results from our analysis. Detection of TSP-1 can identify subgroups of high-risk patients with poor outcomes.\u003c/p\u003e\n\u003cp\u003eIn addition, Kang et al found Sphingosylphosphorylcholine induces TSP-1 secretion which might play an important role in epithelial-mesenchymal transition since migration and invasion are the key indicators of epithelial-mesenchymal transition [47]. Then, the migration and invasion of breast cancer were significantly interrupted when they knocked down TSP-1. Moreover, in breast cancer patients, the high expression of TSP-1 was significantly associated with poor RFS and MFS [10, 47, 48].\u003c/p\u003e\n\u003cp\u003eWe used subgroup analyses to find out the influence of nationality, dominant ethnicity, main pathological type, disease type, assay method and source of HR on the relationship between TSP-1 and patient prognosis. With regard to the ethnic subgroup analysis, we made a distinction between Asians and Caucasians to clarify the impacts of different genetic backgrounds on the results. Interestingly, the analysis showed a significant association between the high expression of TSP-1 and OS/PFS/MFS (HR = 1.40, 95%CI: 0.77\u0026ndash;2.53) (HR = 1.80, 95%CI: 1.34\u0026ndash;2.40; P＜0.001) in Caucasians, but not in Asians. The reason may be attributed to differences in genetic background and environmental exposure. Secondly, OS and PFS/MFS of breast cancer and gynecological cancer in disease type subgroup were remarkable poor. Campone et al deem TSP1 as bad prognostic markers by Kaplan-Meier method and immunohistochemistry (IHC) in triple-negative breast cancers [24]. Some studies have shown that TSP-1 promotes the invasiveness of melanoma which declared TSP-1 is a poor prognostic marker [49]. Nevertheless, other research argued that TSP-1 could significantly inhibit the cell viability of Retinoblastoma cells both in vitro and in vivo [50]. To sum up, the prognostic value of TSP-1 may be different in various cancers. However, more studies are required to confirm the clinical significance of TSP-1 in many samples.\u003c/p\u003e\n\u003cp\u003eFurthermore, the OS (HR=1.48; 95%CI: 1.18~1.87; P=0.001) and PFS/MFS (HR = 1.63, 95%CI: 1.24\u0026ndash;2.15; P=0.001) was significantly worse in \u0026ldquo;reported\u0026rdquo; group but not in the SC group. Throughout this literature, 13 of the 24 studies with survival information did not provide the HRs, so we could only gather the data from Kaplan-Meier curves. There may be some slight errors between the accurate data and the estimated HRs and their 95% CIs from the Kaplan-Meier curves, leading to unreliable results. In other subgroups, we did not find any statistical significance.\u003c/p\u003e\n\u003cp\u003eIt should be noted that heterogeneity is a potential and critical issue that should not be ignored when discussing the results of Meta-analysis. We believe that the mild heterogeneity observed in OS is acceptable. Moreover, the heterogeneity of PFS/DFS was greatly reduced by subgroup analysis. Sensitivity analysis was performed to assess the reliability of results which revealed that the pooled HR did not significantly change by omitting any individual studies, meaning that the results of this meta-analysis are credible. no evidence of publication bias was noted.\u003c/p\u003e\n\u003cp\u003eAlthough this study provided a comprehensive meta-analysis for the prognostic role of TSP-1 in multiple cancers, several limitations do exist. First, Heterogeneity was noted among the selected studies. The existence of heterogeneity may be contributing to the unique characteristics, such as the nationality, dominant ethnicity, the main pathological type, disease type, assay method, source of HR and critical values of TSP-1 expression. Second, it was difficult to determine a standard expression cutoff value because of different cancers, varied assay method and diverse detected sample in the included studies. This could result in bias in the effectiveness of TSP-1 as a prognostic factor. Most studies have established a median expression, IHC intensities or a scoring system as the cutoff value. Therefore, pooled outcomes may be greater or lower than the actual value and cause bias in the results. What's more, the relatively small number of studies on PFS/MFS and DFS/RFS is a limitation, further studies with more selected data and enrolled patients are needed. As mentioned above, the data in SC group extracted through Kaplan-Meier curves may not be accurate. Finally, only English articles are accepted in this article, which may cause deviations in the results. These limitations should be addressed in further research and be considered when drawing conclusions.\u003c/p\u003e\n\u003cp\u003eIn conclusion, TSP-1 might serve as an effective index in evaluating the progress and prognosis of multiple cancers, especially in breast and gynecologic cancer, and may be utilized to improve targeted therapies. In order to accurately evaluate the role of TSP-1 as a prognostic factor, more clinical studies are required before TSP-1 is applied, especially for single type of cancer.\u003c/p\u003e\n\u003ch2\u003e\u0026nbsp;\u003c/h2\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn this paper, we firstly evaluated whether TSP-1 was an accurate prognostic prediction for multiple cancers. Our data provided convincing evidence that high expression of TSP-1 was associated with adverse cancer prognosis. However, further in-depth and larger-scale studies are needed to support our results.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eTSP-1: Thrombospondin-1; HRs: hazard ratio; CIs: confidence intervals; OS: overall survival; PFS: progression-free survival; MFS: metastasis-free survival; DFS: disease-free survival; RFS: recurrence-free survival.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data generated or analyzed during this study are included in this manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was supported by National Natural Science Foundation of China (grant numbers 81672532), Jiangsu Province\u0026rsquo;s Key Provincial Talents Program (ZDRCA2016012), Natural Science Foundation of Jiangsu Province (NO.BK20191077) and Postgraduate Research \u0026amp; Practice Innovation Program of Jiangsu Province (grant number KYCX18-1488).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eStudy design: LC and LJ. Acquisition, analysis and interpretation of data: SSJ, DHY and YT. Statistical analysis: SSJ, YT and LJC. Writing manuscript: SSJ and DHY. Revision of manuscript: LBJ and SPF. All authors have read and approved the final version of manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe would like to thank the participants in the included studies for their contributions.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eBornstein P, Sage EH. Thrombospondins. Methods Enzymol. 1994; 245:62-85.\u003c/li\u003e\n\u003cli\u003eAdams JC. Thrombospondins: multifunctional regulators of cell interactions. Annu Rev Cell Dev Biol. 2001; 17:25-51.\u003c/li\u003e\n\u003cli\u003eAdams JC, Lawler J. The thrombospondins. Cold Spring Harb Perspect Biol. 2011; 3(10):a009712.\u003c/li\u003e\n\u003cli\u003eWang J, Li Y. CD36 tango in cancer: signaling pathways and functions. 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J Hepatobiliary Pancreat Sci. 2016; 23(9):565-573.\u003c/li\u003e\n\u003cli\u003eCampone M, Valo I, Jezequel P, Moreau M, Boissard A, Campion L, Loussouarn D, Verriele V, Coqueret O, Guette C. Prediction of Recurrence and Survival for Triple-Negative Breast Cancer (TNBC) by a Protein Signature in Tissue Samples. Mol Cell Proteomics. 2015; 14(11):2936-2946.\u003c/li\u003e\n\u003cli\u003eEto S, Yoshikawa K, Shimada M, Higashijima J, Tokunaga T, Nakao T, Nishi M, Takasu C, Sato H, Kurita N. The relationship of CD133, histone deacetylase 1 and thrombospondin-1 in gastric cancer. Anticancer Res. 2015; 35(4):2071-2076.\u003c/li\u003e\n\u003cli\u003eYao L, Dong H, Luo Y, Du J, Hu W. Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer. PLoS One. 2014; 9(4):e96206.\u003c/li\u003e\n\u003cli\u003eSharma BK, Srinivasan R, Kapil S, Singla B, Chawla YK, Chakraborti A, Saini N, Duseja A, Das A, Kalra N\u003cem\u003e et al\u003c/em\u003e. Angiogenic and anti-angiogenic factor gene transcript level quantitation by quantitative real time PCR in patients with hepatocellular carcinoma. Mol Biol Rep. 2013; 40(10):5843-5852.\u003c/li\u003e\n\u003cli\u003ePectasides D, Papaxoinis G, Kotoula V, Fountzilas H, Korantzis I, Koutras A, Dimopoulos AM, Papakostas P, Aravantinos G, Varthalitis I\u003cem\u003e et al\u003c/em\u003e. Expression of angiogenic markers in the peripheral blood of docetaxel-treated advanced breast cancer patients: a Hellenic Cooperative Oncology Group (HeCOG) study. Oncol Rep. 2012; 27(1):216-224.\u003c/li\u003e\n\u003cli\u003eNakao T, Kurita N, Komatsu M, Yoshikawa K, Iwata T, Utsunomiya T, Shimada M. Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer. Int J Clin Oncol. 2011; 16(2):145-152.\u003c/li\u003e\n\u003cli\u003eZhou ZQ, Cao WH, Xie JJ, Lin J, Shen ZY, Zhang QY, Shen JH, Xu LY, Li EM. Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma. BMC Cancer. 2009; 9:291.\u003c/li\u003e\n\u003cli\u003eRandall LM, Monk BJ, Darcy KM, Tian C, Burger RA, Liao SY, Peters WA, Stock RJ, Fruehauf JP. Markers of angiogenesis in high-risk, early-stage cervical cancer: A Gynecologic Oncology Group study. Gynecol Oncol. 2009; 112(3):583-589.\u003c/li\u003e\n\u003cli\u003eSecord AA, Darcy KM, Hutson A, Lee PS, Havrilesky LJ, Grace LA, Berchuck A. Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study. Gynecologic oncology. 2007; 106(1):221‐232.\u003c/li\u003e\n\u003cli\u003eSutton CD, O'Byrne K, Goddard JC, Marshall LJ, Jones L, Garcea G, Dennison AR, Poston G, Lloyd DM, Berry DP. Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis. Clin Cancer Res. 2005; 11(18):6567-6573.\u003c/li\u003e\n\u003cli\u003ePoon RT, Chung KK, Cheung ST, Lau CP, Tong SW, Leung KL, Yu WC, Tuszynski GP, Fan ST. Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma. Clin Cancer Res. 2004; 10(12 Pt 1):4150-4157.\u003c/li\u003e\n\u003cli\u003eAishima S, Taguchi K, Sugimachi K, Asayama Y, Nishi H, Shimada M, Sugimachi K, Tsuneyoshi M. The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. Int J Surg Pathol. 2002; 10(1):47-56.\u003c/li\u003e\n\u003cli\u003eYou J, Zhang X, Zhang J, Chen H, Liu Y, Sun L. Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance. Zhongguo Fei Ai Za Zhi. 2000; 3(3):175-179.\u003c/li\u003e\n\u003cli\u003eYao L, Zhao YL, Itoh S, Wada S, Yue L, Furuta I. Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival. Oral Oncol. 2000; 36(6):539-544.\u003c/li\u003e\n\u003cli\u003eYang S, Guo LJ, Tang XF, Tan K, Gong RG, Li A, Yu T, Gao QH, Xuan M, Wen YM\u003cem\u003e et al\u003c/em\u003e. The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis. Int J Oral Maxillofac Surg. 2010; 39(1):29-35.\u003c/li\u003e\n\u003cli\u003eWada H, Nagano H, Yamamoto H, Yang Y, Kondo M, Ota H, Nakamura M, Yoshioka S, Kato H, Damdinsuren B\u003cem\u003e et al\u003c/em\u003e. Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int. 2006; 26(4):414-423.\u003c/li\u003e\n\u003cli\u003eMaeda K, Nishiguchi Y, Kang SM, Yashiro M, Onoda N, Sawada T, Ishikawa T, Hirakawa K. Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer. Oncol Rep. 2001; 8(4):763-766.\u003c/li\u003e\n\u003cli\u003eKodama J, Hashimoto I, Seki N, Hongo A, Yoshinouchi M, Okuda H, Kudo T. Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis. Clin Cancer Res. 2001; 7(9):2826-2831.\u003c/li\u003e\n\u003cli\u003eNakamura Y, Miyata Y, Takehara K, Asai A, Mitsunari K, Araki K, Matsuo T, Ohba K, Sakai H. The Pathological Significance and Prognostic Roles of Thrombospondin-1, and -2, and 4N1K-peptide in Bladder Cancer. Anticancer Res. 2019; 39(5):2317-2324.\u003c/li\u003e\n\u003cli\u003eTzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC\u003cem\u003e et al\u003c/em\u003e. Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis. Clin Cancer Res. 2017; 23(9):2335-2345.\u003c/li\u003e\n\u003cli\u003eFontana A, Filleur S, Guglielmi J, Frappart L, Bruno-Bossio G, Boissier S, Cabon F, Clezardin P. Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo. Int J Cancer. 2005; 116(5):686-691.\u003c/li\u003e\n\u003cli\u003eDawson DW, Volpert OV, Pearce SF, Schneider AJ, Silverstein RL, Henkin J, Bouck NP. Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. Mol Pharmacol. 1999; 55(2):332-338.\u003c/li\u003e\n\u003cli\u003eDawson DW, Pearce SF, Zhong R, Silverstein RL, Frazier WA, Bouck NP. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol. 1997; 138(3):707-717.\u003c/li\u003e\n\u003cli\u003eKang JH, Kim HJ, Park MK, Lee CH. Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2. Biomol Ther (Seoul). 2017; 25(6):625-633.\u003c/li\u003e\n\u003cli\u003eSid B, Langlois B, Sartelet H, Bellon G, Dedieu S, Martiny L. Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity. Int J Biochem Cell Biol. 2008; 40(9):1890-1900.\u003c/li\u003e\n\u003cli\u003eJayachandran A, Anaka M, Prithviraj P, Hudson C, McKeown SJ, Lo PH, Vella LJ, Goding CR, Cebon J, Behren A. Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma. Oncotarget. 2014; 5(14):5782-5797.\u003c/li\u003e\n\u003cli\u003eChen P, Yu N, Zhang Z, Zhang P, Yang Y, Wu N, Xu L, Zhang J, Ge J, Yu K\u003cem\u003e et al\u003c/em\u003e. Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair. Oncotarget. 2016; 7(5):6105-6120.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Additional File Legends","content":"\u003cp\u003eFigure S1: Forest plots of merged analyses for DFS/RFS associated with TSP-1 expression.\u003c/p\u003e\n\u003cp\u003eFigure S2: Begg\u0026rsquo;s funnel plots of the publication bias.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0); font-size: 10px; font-family: Verdana, Geneva, sans-serif;\"\u003eTable.1 Main characteristics of studies included in the meta-analysis\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:669.0pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:80.65pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFirst author, Publication year\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:46.75pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCase nationality\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:29.65pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMale(%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:50.25pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDominant ethnicity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:115.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMain pathological type\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:67.5pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDisease type\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:40.95pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDetected sample\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:44.7pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOutcome measures\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:46.4pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSource of HR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:66.2pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaximum months of follow-up\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:80.95pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.6pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAssay method\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:15.6pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"height:15.6pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNakamura et al, 2019\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUrothelial carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBladder cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e95\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTzeng et al, 2016\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eChina\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSquamous cell carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eEsophagus cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e228\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRouanne et al, 2016\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFrance\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLung cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSerum\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS/DFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eELISA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTeraoku et al, 2016\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eColon cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS/DFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e168\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCampone et al, 2015\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFrance\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBreast cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e279\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eEto et al, 2015\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGastric cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYao et al, 2014\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eChina\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNon-Small Cell Lung Cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLung cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS/DFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eELISA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSharma et al, 2013\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIndia\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e92.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHepatocellular Carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLiver cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePCR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePectasides \u0026nbsp;et al, 2012\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGreece\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBreast cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS/PFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePCR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNakao et al, 2011\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGastric cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eZhou \u0026nbsp;et al, 2009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eChina\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSquamous cell carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eesophagus cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRandall et al, 2009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUSA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSquamous cell carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCervical cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS/PFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e184.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYang et al, 2009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eChina\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003emucoepidermoid carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOral cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSecord et al, 2007\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUSA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eEpithelial cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOvarian cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS/PFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e110\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eImmunoblot analysis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWada et al, 2006\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHepatocellular Carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLiver cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSutton \u0026nbsp;et al, 2005\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUK\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eColon cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:33.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDextran polymer conjugate wwo-step visualization system\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:33.75pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFontana et al, 2005\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFrance\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBreast cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e160\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePoon \u0026nbsp;et al, 2004\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eChina\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHepatocellular Carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLiver cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAishima et al, 2002\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIntrahepatic Cholangiocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLiver cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e120\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaeda et al, 2001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAdenocarcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eColon cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eStraume et al, 2001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNorway\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCaucasian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMelanomas\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSkin cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e210\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eKodama et al, 2001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSquamous cell carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCervical cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eReported\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePCR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYou et al, 2000\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eChina\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSquamous cell carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLung cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e120\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;height:11.25pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:11.25pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.65pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYao et al, 2000\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eJapan\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:29.65pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAsian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSquamous cell carcinoma\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOral cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTissue\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.7pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIHC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"height:12.0pt;border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS, overall survival; DFS, disease-free survival; PFS, progression-free survival; SC: survival curve; IHC, Immunohistochemistry; PCR, polymerase chain reaction; ELISA, enzyme linked immunosorbent assay; N/A, not available.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable.2 HRs and 95% CIs of cancer prognosis and progression associated with TSP-1 expression in included studies\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:100.0%;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:10.92%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFirst author, Publication year\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:11.02%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCut-off value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:25.64%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNumber of cases\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:none;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:15.92%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:none;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:13.92%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDFS/RFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:14.82%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePFS/MFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:9.6%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHigh expression\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003elow expression\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.48%;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.34%;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:11.64%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHR (95% CI)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eP Value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHR (95% CI)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eP Value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHR (95% CI)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:25.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eP Value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNakamura et al, 2019\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10% \u0026nbsp;of the cells were positive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e120\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;border:none;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e206\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;border:none;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;border:none;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;border:none;border-right:solid white 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.11 (0.56-2.19)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:10.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.774\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTzeng et al, 2016\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003evalue =40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e183\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.61 (0.38-0.99)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRouanne et al, 2016\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e171\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.15 (0.03\u0026ndash;0.89)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.39 (0.10\u0026ndash;1.45)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTeraoku et al, 2016\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003escore=3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e94\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.61 (1.00-8.16)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026lt;0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.63 (0.38-1.06)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCampone et al, 2015\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003epositive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e19\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.86 (0.08-8.85)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.0364\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eEto et al, 2015\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10% \u0026nbsp;of the cells were positive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.53 (0.24-1.18)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026lt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYao et al, 2014\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.52 (0.91\u0026ndash;3.14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.088\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.62 (0.91\u0026ndash;3.76)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.112\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSharma et al, 2013\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.982 (0.541-1.784)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.953\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePectasides \u0026nbsp;et al, 2012\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e120\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.84 (1.11-3.05)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.018\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.73 (1.11-2.69)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.016\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNakao et al, 2011\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e30% \u0026nbsp;of the cells were positive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.54 (0.26-1.14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026lt;0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eZhou \u0026nbsp;et al, 2009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10 percentile\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e80\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.41 (0.07-2.38)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.042\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRandall et al, 2009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003escore=3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e112\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e166\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.44 (0.70\u0026ndash;2.75)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.30 (0.67\u0026ndash;2.54)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYang et al, 2009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003emoderate staining\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.77 (0.18-3.42)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.012\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSecord et al, 2007\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.93 (1.12-3.32)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.018\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.19 (1.29-3.71)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWada et al, 2006\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003escore=2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.85 (1.05-7.72)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.689\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSutton \u0026nbsp;et al, 2005\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedian\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e137\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e182\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.82 (1.0-3.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFontana et al, 2005\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003epositive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e77\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.25 (0.81-6.27)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePoon \u0026nbsp;et al, 2004\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.49 (0.63-9.86)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.014\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAishima et al, 2002\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e50% \u0026nbsp;of the cells were positive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.39 (0.70-2.78)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaeda et al, 2001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003epositive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e89\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e61\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e150\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.37 (1.41-3.83)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eStraume et al, 2001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003emoderate staining\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e77\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e104\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e181\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.07 (1.27-3.40)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.0001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eKodama et al, 2001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003epositive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.16 (1.25-7.98)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.015\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYou et al, 2000\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5% \u0026nbsp;of the cells were positive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.06%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.49 (0.48-4.58)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.86%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.0163\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.18%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:7.72%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.08%;padding:0in 5.4pt 0in 5.4pt;height:9.0pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN/A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:10.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYao et al, 2000\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.02%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003emoderate staining\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.6%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.22%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.82%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.6%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.06%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.75pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.81 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%;font-size:15px;font-family:DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0); font-size: 10px; font-family: Verdana, Geneva, sans-serif;\"\u003eOS, overall survival; DFS, disease-free survival; MFS, metastasis-free survival; RFS, recurrence-free survival; PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; N/A, not available.\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"TSP-1, Malignant neoplasm, Prognosis, Overall survival, Meta-analysis","lastPublishedDoi":"10.21203/rs.3.rs-20184/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-20184/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground Published studies present conflicting data regarding the impact of Thrombospondin-1 (TSP-1) expression on prognosis of various cancers. We performed this meta-analysis to illustrate the preliminary predictive value of TSP-1. \u003c/p\u003e\u003cp\u003eMethods Twenty-four studies with a total of 2379 patients were included. A comprehensive literature search was performed by using PubMed, Cochrane Library, Web of Science, Embase, and hand searches were also conducted of relevant bibliographies. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for patient survival and disease recurrence were initially identified to explore relationships between TSP-1 expression and patient prognosis. \u003c/p\u003e\u003cp\u003eResults A total of 24 eligible studies were included in this meta-analysis. Our results showed that high level of TSP-1 was correlated significantly with poor overall survival (OS) (HR=1.40, 95% CI: 1.17~1.68; P＜0.001). However, high TSP-1 expression predicted no significant impact on progression-free survival (PFS)/ metastasis-free survival (MFS) (HR=1.35, 95%CI: 0.87-2.10; P=0.176) and disease-free survival (DFS)/ recurrence-free survival (RFS) (HR = 1.40, 95%CI: 0.77–2.53; P=0.271). In addition, we performed subgroup analyses which showed that high TSP-1 expression predicted poor prognosis in breast cancer and gynecological cancer. Additionally, the relatively small number of studies on PFS/MFS and DFS/RFS is a limitation. The data extracted through Kaplan-Meier curves may not be accurate. Moreover, only English articles were included in this article, which may lead to deviations in the results.\u003c/p\u003e\u003cp\u003eConclusions Our findings indicated high TSP-1 expression may act as a promising biomarker of poor prognosis in cancers, especially in breast cancer and gynecological cancer.\u003c/p\u003e\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","manuscriptTitle":"Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2020-06-19 05:12:01","doi":"10.21203/rs.3.rs-20184/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"checksComplete","content":"","date":"2020-06-18T12:00:00+00:00","index":"","fulltext":""},{"type":"decision","content":"Accept","date":"2020-06-18T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-06-05 14:01:04","doi":"10.21203/rs.3.rs-20184/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-06-05T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-06-04T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **None**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n"},{"type":"reviewerAgreed","content":"","date":"2020-06-03T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-06-03T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **'I declare that I have no competing interests'**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n"},{"type":"reviewersInvited","content":"","date":"2020-06-02T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-06-02T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2020-06-01T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-05-31T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-05-31T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-04-01 14:58:04","doi":"10.21203/rs.3.rs-20184/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2020-05-18T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nMinor comments:\n1. In Abstract, Results section \"A total of 24 eligible studies were included in this meta-analysis. Our results showed that high level of TSP-1 was correlated significantly with poor overall survival ( OS ) (HR=1.40, 95% CI: 1.17~1.68; add p value = …………. ). However, high TSP-1 expression predicted no significant impact on progression-free survival ( PFS )/ metastasis-free survival (MFS ) (HR=1.35, 95%CI: 0.87-2.10; add p value = ………….) and disease-free survival ( DFS )/ recurrencefree survival ( RFS ) (HR = 1.40, 95%CI: 0.77-2.53; add p value = ………….).\n2. In the Background section add reference to \"Thrombospondin gene family plays a role in extensive physiological and pathological processes, including development, angiogenesis, inflammation and neoplasia (add reference). This TSP family interact with a variety of membrane proteins on the cell surface, such as proteoglycans, integrins, CD36 and CD47 (Add reference). Under the transmission 50 microscope, TSP-1 is composed of three identical peptide chains, each showing a 51 spherical amino at one end and a spherical carboxyl group at the other end, connected by a 52 slender rod-like arm in the middle (Add reference).\n3. In the results sub section OS associated with TSP-1 expression and PFS/MFS and DFS/RFS associated with TSP-1 expression add exact P value in place of P=0.000.\n4. From all figure titles delete the word notes.\n5. In the discussion part the reference are not cited properly. The Reference Kang et al is 44 in the list of references. Please check this error and rectify the same. \"In addition, Kang et al found Sphingosylphosphorylcholine induces TSP-1 secretion 268 which might play an important role in epithelial-mesenchymal transition since migration 269 and invasion are the key indicators of epithelial-mesenchymal transition [7, 43]. Then, 270 the migration and invasion of breast cancer were significantly interrupted when they 271 knocked down TSP-1. Moreover, in breast cancer patients, the high expression of 272 TSP-1 was significantly associated with poor RFS and MFS [44].\"\n6. In the table 1 column Maximum mouths of follow-up, replace the word mouths with months. Replace column Detected sample with Sample used.\n7. Table 2 replace column case Number with Number of cases\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **None**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n"},{"type":"decision","content":"Minor revision","date":"2020-05-18T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-04-30T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-04-26T12:00:00+00:00","index":1,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n\nComments to Author:\n---\nFollowings comments need to addressed for this manuscript:\nComments-\n1. PRISMA guidelines must be followed for Systematic reviews and Meta analysis. Authors should check the guidelines and do the required corrections as per them. For e.g. Limitations of the study must be added in the abstract (visit: PLoS Med.209. 6(7): e1000097. for guidelines).\nConclusion of the abstract doesn't matches with the conclusion of study (TSP-1 expression may serve as a promising biomarker of poor prognosis). Correct, if needed or provide suitable reasons for that. Who the statement is justified \"promising biomarker of poor prognosis and novel therapeutic target in cancers\"\n2. Authors should provide proper citations for the text in various sections of manuscript. Information section, Line 43-53, page 3, Line 105 and 113, page number-6 and Line 243-245). Likewise check the manuscript thoroughly and provide relevant citation wherever necessary.\n3. Authors should write abbreviations of words OS, RFS, and DFS while mentioning these words for the first time (Page-5, Line-101) and check the manuscript thoroughly for the same.\n4. Authors should include the Individual participant data for analysis.\n5. While discussing Inclusion and Exclusion criteria, authors didn't mention the gender biasness to be included or excluded. But, in table-1 only male percentage is given. Moreover, Non small cell lung cancer is usually found more in case of males (ESMO Open. 2018; 3(3): e000344) and likewise in many cancers gender does play an important role. Then why the gender biasness is excluded in this study?\n6. Authors have mentioned that TSP-1 plays a protective role as well. But, the study included the case group or patient group only. Why the control samples are not included for the comparison? How can results be justified without taking control samples?\n7. In the Study selection part of result section, the criteria mentioned for selected articles is incorrect (Line 120-122, page number 6). The mentioned points highlight the excluded articles not the included ones.\n8. The conclusion of the study states that 'TSP-1 was independently associated with adverse cancer prognosis' (Line-331, page-19). What does the independent association means?\n9. The font size in figures (2-5) is too small and isn't clearly visible. It needs to be corrected.\n10. Authors should check the format of references provided at the end. The title of the study in few references is in bold whereas for others it is normal. Why?\n11. Manuscript should be thoroughly checked for grammatical errors (For e.g. Line number 276, discussion section, 'We are divided'....)\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Unable to assess**\n* Are the conclusions drawn adequately supported by the data shown?: **No**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Needs some language corrections before being published**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: **\nI agree to the open peer review policy of the journal**\n"},{"type":"reviewerAgreed","content":"","date":"2020-04-11T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-04-06T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-03-17T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-03-16T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-03-16T12:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"","date":"2020-03-13T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"3d5ae357-98f2-4089-b4f1-d6e1ab78c5a0","owner":[],"postedDate":"June 19th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":114200,"name":"Medical Genetics"}],"tags":[],"updatedAt":"2020-07-05T15:01:24+00:00","versionOfRecord":{"articleIdentity":"rs-20184","link":"https://doi.org/10.1186/s12881-020-01073-3","journal":{"identity":"bmc-medical-genetics","isVorOnly":false,"title":"BMC Medical Genetics"},"publishedOn":"2020-06-29 12:00:00","publishedOnDateReadable":"June 29th, 2020"},"versionCreatedAt":"2020-06-19 05:12:01","video":"","vorDoi":"10.1186/s12881-020-01073-3","vorDoiUrl":"https://doi.org/10.1186/s12881-020-01073-3","workflowStages":[]},"version":"v3","identity":"rs-20184","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-20184","identity":"rs-20184","version":["v3"]},"buildId":"oE6Zbj460LM0Up2FdVbMZ","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}