Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts

Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts DOI: https://doi.org/10.28932/jmh.v1i1.496Abstract Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cystDownloads Download data is not yet available. Downloads Published 2015-02-27 How to Cite 1. Anwar R, Alif M, Pribadi A. Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts. J. Med. Health [Internet]. 2015Feb.27 [cited 2026Jun.9];1(1). Available from: https://journal.maranatha.edu/index.php/jmh/article/view/496 Issue Section Articles License Authors who publish with this journal agree to the following terms: - Authors retain the copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.