Овариальная ароматаза р450 при нормогонадотропной недостаточности яичников

The object of this study was to determine the role of ovarian aromatase р450 in the pathogenesis of primary ovarian deficiency. The study included 48 patients with normogonadotropic ovulation, associated with the external genital endometriosis (EGE) in 29 women, and polycystic ovarian syndrome (PCOS) in 19 women. The comparison group included 16 women with normal ovulatory menstrual cycles. The expression of aromatase р450 by ovarian granulose cells was determined with the help of immunohistochemical method. Ovarian biopsy materials were obtained during laparoscopy at the 10th -12th day of menstrual cycle. The survey also included pelvic organs ultrasound, detection of gonadotropins, androgens and estradiol level in the serum. According to the results of the study we may conclude that during normogonadotropic ovulation aromatase р450 expression in ovarian granulose cells is down regulated. The deficiency of aromatase р450 in EGE and PCOS patients causes inadequate preovulatory surge of estradiol in serum and anovulation.