Global sensitivity analysis for investigation of bacterial physiology in complex media with FBA-PRCC

Abstract In this paper we propose the use of FBA-PRCC approach, which is based on sampling flux space and global sensitivity analysis (GSA), for analysis of the GEM FBA solution space in the nutrient-rich environment. We identify two new modes of interaction between species and metabolites: attraction and avoidance and propose the way of their use. We have shown that sensitivity coefficients provide additional information about behavior of the bacteria in the nutrient-rich environment in comparison to standard knockouts, FVA and CoPE-FBA analysis. Competing Interest Statement The authors have declared no competing interest. Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.