Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

This study characterized uterine natural killer (NK) cells in women presenting with infertility or recurrent pregnancy loss, comparing those with associated endometriosis to those without. Using uterine tissue to examine NK cell phenotype and distribution, the authors report differences in uterine NK cell characteristics linked with the presence of endometriosis in this patient group. A key limitation is that the analysis is cross-sectional and observational, so it cannot establish whether altered uterine NK cells cause infertility or pregnancy loss. This paper is centrally about endometriosis — specifically, it characterizes uterine NK cells in women with infertility or recurrent pregnancy loss in the context of associated endometriosis.

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