Influence of serotonin on progesterone and estradiol secretion of cultured human granulosa cells

József Bódis, J Bódis, A Török, Á. Török, H R Tinneberg, Hans‐Rudolf Tinneberg, V Hanf, Volker Hanf, M. Hamori, P. Cledon
Fertility and sterility · 1992 · vol. 57(5) , pp. 1008–1011 · doi:10.1016/s0015-0282(16)55017-1 · PMID:1572466 · W2414959973
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This study investigated the impact of serotonin on the secretion of progesterone and estradiol by cultured human granulosa cells.

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Abstract

OBJECTIVE: To explore the direct action of serotonin on progesterone (P) and estradiol (E2) secretion of human granulosa cells cultured in serum-free medium. DESIGN: Progesterone and E2 production was measured in the presence and absence of serotonin, propranolol, or cycloheximide using radioimmunoassays; statistical analysis of the data was performed by ANOVA. SETTING: In vitro fertilization and embryo transfer (IVF-ET) for infertility treatment at the University Women's Hospital, University of Tübingen, Germany. PATIENTS, PARTICIPANTS: Fourteen women, 30 +/- 3 years old, undergoing IVF-ET. RESULTS: Serotonin stimulated a dose-related increase in P secretion with a maximal stimulatory effect at 10(-4) M. This response was blocked specifically by the beta-receptor antagonist propranolol (10(-4) M). Estradiol secretion in response to serotonin was dose-independent stimulation, which was highest at 10(-6) M and was inhibited by 10(-4) M propranolol. The protein synthesis inhibitor cycloheximide markedly reduced the stimulatory effect of serotonin on P secretion. Estradiol production in the presence of cycloheximide was significantly reduced; serotonin had no stimulatory effect under these conditions. CONCLUSION: Serotonin may have a physiological role in the corpus hemorrhagicum, when luteinization is initiated.

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MeSH descriptors

Estradiol Granulosa Cells Progesterone Serotonin Adult Cells, Cultured Cycloheximide Cycloheximide Dose-Response Relationship, Drug Estradiol Female Granulosa Cells Humans Osmolar Concentration Progesterone Propranolol Propranolol Serotonin

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