“Synthesis and Pharmacological Assessment of Novel Amino-Anthracene -9, 10 Dione Derivatives as Potent Neuroprotective and anti-depressant agents”

“Synthesis and Pharmacological Assessment of Novel Amino-Anthracene -9, 10 Dione Derivatives as Potent Neuroprotective and anti-depressant agents” | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article “Synthesis and Pharmacological Assessment of Novel Amino-Anthracene -9, 10 Dione Derivatives as Potent Neuroprotective and anti-depressant agents” Chandrakant Suryawanshi, DR. R.D.Wagh Rajendra This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3109994/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract “Monoamine-oxidase ‘MAO’ is located at the exterior films of membrane-bound cell organelles prison cell of the liver, abdominal inner lining, brain, and additional structures.” “Monoamine-oxidase catalyzes the oxidative deamination of exogenous and endogenous ‘amines, including ‘4-(2-aminoethyl) benzene-1, 2-diol, a 5-hydroxy derivative of tryptamine, norepinephrine, ‘tyramine, and ‘tryptamine.” “Monoamine-oxidase appears as binary isozymes, ‘Monoamine-oxidase A and B.” “Monoamine-oxidase-A differently catalyzes the oxidation of ‘the 5-hydroxy derivative of tryptamine and ‘nor-epinephrine and is introverted by ‘Clorgyline. ‘Monoamine-oxidase -B selectively catalyzes the oxidation of phenyl-ethylamine and benzylamine, and it is inhibited by ‘‘Pargyline, and Deprenyl.” “Monoamine-oxidase-A is complicated in psychiatric situations, depression, and ‘Monoamine-oxidase -B in Neuro-logical illnesses such as Parkinson´s, and Alzheimer´s illnesses.” “ During a target-based airing of natural products using two isoforms of recombinant human ‘Monoamine-oxidase A, and B. ‘Purpurin, and Alizarin (a natural anthraquinone derived) were found to effectively and selectively inhibit ‘Monoamine-oxidase -A, with an Inhibitory concentration 50 value of 2.50 µM and Inhibitory concentration 50 value of 30.1 µM respectively.” 21 “The findings of this learning propose Anthraquinones ‘purpurin and alizarin are strong or influential, discriminating, reversible inhibitors of ‘Monoamine-oxidase enzyme and that they are considered a new possible lead compound for the progress of novel reversible inhibitors of ‘Monoamine-oxidase enzymes.” “In a previous study, it was also shown that 6 Anthraquinones (chrysophanol, ‘emodin, ‘aloe-emodin, ‘physcion, ‘rhein, and 1, 8-dihydroxyanthraquinone) were observed for inhibitory activity of monoamine oxidase ‘MAO ‘A and B’ from muroid rodent brain mitochondrial.” “Emodin was shown to inhibit ‘Monoamine-oxidase B in a dose-dependent approach with the Inhibitory concentration fifty data 35.4 µm.” 32 “By considering the above insights various Novel synthetic Anthraquinones, Anthracene nine, and ten-dione compounds were developed from 1 to nine.” “MAO -A and B Inhibitory activities of Synthetic Anthracene nine, ten-dione compounds 1 to nine evaluated by ‘Monoamine-oxidase inhibitory assay using black polystyrene nine6-well microtiter plates. “Compounds 1,2,5,8 and nine show significant ‘Monoamine-oxidase -A inhibitions compared to standard Clorgyline, and compounds 1,3,5,8, and nine show significant ‘Monoamine-oxidase -B inhibitions compared to standard Pargyline.” “From the above significant results, we can assume that these compounds could be worth full in Neurodegenerative illnesses such as Parkinson’s disease due to their strong selective ‘Monoamine-oxidase -B action as compared to Pargyline and anti-depressant due to selective ‘Monoamine-oxidase -inhibitions as compared to standard anti-depressant Clorgyline and could be boon in management of depression.” 15,18,30,31 . Anthraquinones Parkinson&rsquo s disease Nor-epinephrine Neurodegenerative disease etc Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3109994","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":214569177,"identity":"7979acc9-d6e7-4df5-9b4f-16595d110e8f","order_by":0,"name":"Chandrakant Suryawanshi","email":"data:image/png;base64,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","orcid":"","institution":"“OBVS’s Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule-424002, Maharashtra”, India.","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Chandrakant","middleName":"","lastName":"Suryawanshi","suffix":""},{"id":214569178,"identity":"514ef47a-b695-47f0-9983-80d4c9b28577","order_by":1,"name":"DR. R.D.Wagh Rajendra","email":"","orcid":"","institution":"“DCS’s ARA College of Pharmacy, Nagaon, Dhule-424002, Maharashtra, India”","correspondingAuthor":false,"submittingAuthor":false,"prefix":"DR.","firstName":"R.D.Wagh","middleName":"","lastName":"Rajendra","suffix":""}],"badges":[],"createdAt":"2023-06-26 09:44:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3109994/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3109994/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":40731573,"identity":"21af5ef4-3060-47dc-bdff-138aaebf086b","added_by":"auto","created_at":"2023-07-28 16:07:29","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":516970,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3109994/v1_covered_76ec942c-c82c-4db2-8fc4-bbf1fa53c11b.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"“Synthesis and Pharmacological Assessment of Novel Amino-Anthracene -9, 10 Dione Derivatives as Potent Neuroprotective and anti-depressant agents”","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Anthraquinones, Parkinson\u0026rsquo;s disease, Nor-epinephrine, Neurodegenerative disease, etc","lastPublishedDoi":"10.21203/rs.3.rs-3109994/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3109994/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u0026ldquo;Monoamine-oxidase \u0026lsquo;MAO\u0026rsquo; is located at the exterior films of membrane-bound cell organelles prison cell of the liver, abdominal inner lining, brain, and additional structures.\u0026rdquo; \u0026ldquo;Monoamine-oxidase catalyzes the oxidative deamination of exogenous and endogenous \u0026lsquo;amines, including \u0026lsquo;4-(2-aminoethyl) benzene-1, 2-diol, a 5-hydroxy derivative of tryptamine, norepinephrine, \u0026lsquo;tyramine, and \u0026lsquo;tryptamine.\u0026rdquo; \u0026ldquo;Monoamine-oxidase appears as binary isozymes, \u0026lsquo;Monoamine-oxidase A and B.\u0026rdquo; \u0026ldquo;Monoamine-oxidase-A differently catalyzes the oxidation of \u0026lsquo;the 5-hydroxy derivative of tryptamine and \u0026lsquo;nor-epinephrine and is introverted by \u0026lsquo;Clorgyline. \u0026lsquo;Monoamine-oxidase -B selectively catalyzes the oxidation of phenyl-ethylamine and benzylamine, and it is inhibited by \u0026lsquo;\u0026lsquo;Pargyline, and Deprenyl.\u0026rdquo; \u0026ldquo;Monoamine-oxidase-A is complicated in psychiatric situations, depression, and \u0026lsquo;Monoamine-oxidase -B in Neuro-logical illnesses such as Parkinson\u0026acute;s, and Alzheimer\u0026acute;s illnesses.\u0026rdquo; \u0026ldquo; During a target-based airing of natural products using two isoforms of recombinant human \u0026lsquo;Monoamine-oxidase A, and B. \u0026lsquo;Purpurin, and Alizarin (a natural anthraquinone derived) were found to effectively and selectively inhibit \u0026lsquo;Monoamine-oxidase -A, with an Inhibitory concentration 50 value of 2.50 \u0026micro;M and Inhibitory concentration 50 value of 30.1 \u0026micro;M respectively.\u0026rdquo;\u003csup\u003e21\u003c/sup\u003e \u0026ldquo;The findings of this learning propose Anthraquinones \u0026lsquo;purpurin and alizarin are strong or influential, discriminating, reversible inhibitors of \u0026lsquo;Monoamine-oxidase enzyme and that they are considered a new possible lead compound for the progress of novel reversible inhibitors of \u0026lsquo;Monoamine-oxidase enzymes.\u0026rdquo; \u0026ldquo;In a previous study, it was also shown that 6 Anthraquinones (chrysophanol, \u0026lsquo;emodin, \u0026lsquo;aloe-emodin, \u0026lsquo;physcion, \u0026lsquo;rhein, and 1, 8-dihydroxyanthraquinone) were observed for inhibitory activity of monoamine oxidase \u0026lsquo;MAO \u0026lsquo;A and B\u0026rsquo; from muroid rodent brain mitochondrial.\u0026rdquo; \u0026ldquo;Emodin was shown to inhibit \u0026lsquo;Monoamine-oxidase B in a dose-dependent approach with the Inhibitory concentration fifty data 35.4 \u0026micro;m.\u0026rdquo;\u003csup\u003e32\u003c/sup\u003e\u0026ldquo;By considering the above insights various Novel synthetic Anthraquinones, Anthracene nine, and ten-dione compounds were developed from 1 to nine.\u0026rdquo; \u0026ldquo;MAO -A and B Inhibitory activities of Synthetic Anthracene nine, ten-dione compounds 1 to nine evaluated by \u0026lsquo;Monoamine-oxidase inhibitory assay using black polystyrene nine6-well microtiter plates. \u0026ldquo;Compounds 1,2,5,8 and nine show significant \u0026lsquo;Monoamine-oxidase -A inhibitions compared to standard Clorgyline, and compounds 1,3,5,8, and nine show significant \u0026lsquo;Monoamine-oxidase -B inhibitions compared to standard Pargyline.\u0026rdquo; \u0026ldquo;From the above significant results, we can assume that these compounds could be worth full in Neurodegenerative illnesses such as Parkinson\u0026rsquo;s disease due to their strong selective \u0026lsquo;Monoamine-oxidase -B action as compared to Pargyline and anti-depressant due to selective \u0026lsquo;Monoamine-oxidase -inhibitions as compared to standard anti-depressant Clorgyline and could be boon in management of depression.\u0026rdquo; \u003csup\u003e15,18,30,31\u003c/sup\u003e.\u003c/p\u003e","manuscriptTitle":"“Synthesis and Pharmacological Assessment of Novel Amino-Anthracene -9, 10 Dione Derivatives as Potent Neuroprotective and anti-depressant agents”","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2023-07-04 09:35:28","doi":"10.21203/rs.3.rs-3109994/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"a9037f1b-0290-4060-a93c-f24344f41db1","owner":[],"postedDate":"July 4th, 2023","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-07-28T15:59:19+00:00","versionOfRecord":[],"versionCreatedAt":"2023-07-04 09:35:28","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3109994","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3109994","identity":"rs-3109994","version":["v1"]},"buildId":"-HB7Z8yhvgn0wM9Nzuekk","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}