Endometriosis-associated ovarian cancer

С А Леваков, Т.А. Громова, А. Г. Кедрова, Н. А. Шешукова
In: Tumors of female reproductive system · 2016 · vol. 12(4) , pp. 47–51 · doi:10.17650/1994-4098-2016-12-4-47-51 · W2586481022
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses molecular and epidemiological links between endometriosis and ovarian clear cell and endometrioid carcinomas, focusing on ARID1A mutations and PI3K/AKT pathway alterations.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This review paper examines endometriosis-associated ovarian cancer, focusing on the relationship between endometriosis and the development of ovarian malignancy and summarizing key points relevant to this cancer subtype. It synthesizes existing knowledge rather than reporting new experimental or clinical data. Because the format is an overview, it does not provide original methods, patient cohorts, or effect-size estimates, and its conclusions rely on the scope and selection of prior literature. This paper is centrally about endometriosis — specifically, endometriosis-associated ovarian cancer.

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Abstract

This article reviews recent advance in our understanding of ovarian endometriomas, with special reference of atypical epithelial features (atypical endometriosis) and its relationship to neoplasm. Mainly, two epithelial ovarian carcinoma subtypes, the ovarian clear cell carcinomas and the endometrioid ovarian carcinomas, have been molecularly and epidemiologically linked to endometriosis. The clear cell and endometrioid adenocarcinomas have common immunohistochemical markers, genetic changes are the same as atypical endometriosis. The occurrence of ARID1A mutations and alterations in the PI3K/AKT pathway in endometriosis and endometriosis-associated ovarian carcinomas, as well as the possible functional and clinical implications are discussed in this review. Therefore, development of a screening method that can detect mutations of ARID1A and activation of the PI3K/AKT pathway might enable early diagnosis of endometriosis associated ovarian cancers and endometrial cancers.
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Endometriosis-associated ovarian cancer - Authors: Levakov S.A.1, Gromova T.A.1, Kedrova A.G.2, Sheshukova N.A.1 - Affiliations: - I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia - Institute for Advanced Training, Federal Biomedical Agency of Russia - Issue: Vol 12, No 4 (2016) - Pages: 47-51 - Section: ГИНЕКОЛОГИЯ. ОБЗОР - Published: 10.11.2016 - URL: https://ojrs.abvpress.ru/ojrs/article/view/524 - DOI: https://doi.org/10.17650/1994-4098-2016-12-4-47-51 - ID: 524 Cite item Full Text Abstract About the authors S. A. Levakov I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia Author for correspondence. Department of Obstetrics and Gynecology, Institute of Professional Education, Build. 2, 8 Trubetskaya St., Moscow 119991 Russian FederationT. A. Gromova I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia Department of Obstetrics and Gynecology, Institute of Professional Education, Build. 2, 8 Trubetskaya St., Moscow 119991 Russian FederationA. G. Kedrova Institute for Advanced Training, Federal Biomedical Agency of Russia Email: [email protected] Department of Obstetrics and Gynecology, 91 Volokolamskoe Shosse, Moscow 125371 Russian FederationN. A. Sheshukova I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia Department of Obstetrics and Gynecology, Institute of Professional Education, Build. 2, 8 Trubetskaya St., Moscow 119991 Russian Federation

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endometriosis

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