Expression and Significance of Cofilin in Eutopic Endometrium and Ectopic Foci in Patients with Endometriosis

Objective To explore the candidate gene and its function in the eutopic endometrium of endometriosis through detecting the expression of cofilin in endometrium and identifying the role of cofilin in the occurrence and development of endometriosis. Methods The eutopic and ectopic endometria sampled from 23 patients with endometriosis were chosen as experimental group,and the eutopic endometria from 9 patients without endometriosis was taken as control group. The expression of cofilin mRNA was detected by RT-PCR,and the correlation between cofilin expression in eutopic endometria and the severity of endometriosis was analyzed. The cofilin expressions in the proliferative and secretory phases were compared in experimental group. Results The expression of cofilin in eutopic endometria in experimental group was significantly higher than that in control group (P 0.01). In experimental group,the expression of cofilin was higher in ectopic endometria than in eutopic endometria (P 0.05),and there was significant difference in the expression of cofilin in eutopic and ectopic endometria between patients with moderate to severe endometriosis and those with mild endometriosis (P 0.05). There was no significant difference in the expression of cofilin in eutopic and ectopic endometria in experimental group and in eutopic endometria in control group between proliferative and secretory phases (P 0.05). There was significant difference in the expression of cofilin in eutopic endometria during proliferative and secretory phases between experimental and control groups (P 0.05). The difference in the expression of cofilin in eutopic and ectopic endometria was also significant between proliferative and secretory phases in experimental group (P 0.05). Conclusion The unusually high level of cofilin expression in the eutopic endometria in patients with endometriosis may play an important role in the occurrence and development of endometriosis.