Association between IL33-rs146597587 and asthma, allergic rhinitis, or endometriosis risk in the UK Biobank.

Abdou Mousas (4336705), Georgios Ntritsos (4336708), Ming-Huei Chen (73691), Ci Song (396329), Jennifer E. Huffman (220403), Ioanna Tzoulaki (257920), Paul Elliott (27295), Bruce M. Psaty (103721), Paul L. Auer (3987392), Andrew D. Johnson (150072), Evangelos Evangelou (64006), Guillaume Lettre (163230), Alexander P. Reiner (178706)
2017 · doi:10.1371/journal.pgen.1006925.t003 · W6904378094
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This study analyzed data from the UK Biobank to investigate the association between the rare coding variant IL33-rs146597587 and the risk of asthma, allergic rhinitis, or endometriosis. The researchers employed logistic models that adjusted for age, sex, principal components, and conditioning on previously associated common single nucleotide polymorphisms. The analysis focused specifically on determining whether this rare variant independently influences susceptibility to these three conditions after accounting for established genetic factors. Relevance to endometriosis: listed as one indication for genetic risk assessment alongside asthma and allergic rhinitis, though the paper's main focus is on hematological traits and broad inflammatory disease associations.

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Abstract

All analyses were corrected for age, sex, and the first 10 principal components. The direction of the odds ratio is for the rare allele (rs146597587, C-allele on forward strand). The conditional P-values were calculated in a logistic model accounting for genotypes at common single nucleotide polymorphisms (SNPs) previously associated with asthma, allergic rhinitis, or endometriosis: rs343496, rs7032572, rs72699186, rs1342326, rs2381416, rs928413, rs10975519.
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Rare coding variants pinpoint genes that control human hematological traits Table 3 Association between IL33-rs146597587 and asthma, allergic rhinitis, or endometriosis risk in the UK Biobank. All analyses were corrected for age, sex, and the first 10 principal components. The direction of the odds ratio is for the rare allele (rs146597587, C-allele on forward strand). The conditional P-values were calculated in a logistic model accounting for genotypes at common single nucleotide polymorphisms (SNPs) previously associated with asthma, allergic rhinitis, or endometriosis: rs343496, rs7032572, rs72699186, rs1342326, rs2381416, rs928413, rs10975519.

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endometriosis

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