Electrocardiographic abnormalities and Cardiovascular outcomes in systemic autoimmune rheumatic diseases: A scoping review protocol

Objective This Scoping review seeks to carry out a global mapping of the literature on electrocardiographic abnormalities and major adverse cardiovascular outcomes in patients with systemic autoimmune rheumatic diseases.

Systemic autoimmune rheumatic diseases (SARD) constitute a heterogeneous group of inflammatory disorders. Cardiovascular involvement in SARD may result from the involvement of different structures, including the electrical system, leading to rhythm and conduction disturbances. Identifying electrocardiographic changes associated with major adverse cardiovascular events (MACE), such as heart failure, myocardial and cerebral ischemia, may contribute to increased awareness, better management strategies, and potential reduction in morbidity and mortality. Inclusion criteria This review will include articles describing electrocardiographic changes and the occurrence of MACE in adults with autoimmune rheumatic diseases, except type 1 diabetes.

The protocol will follow the JBI methodology, and the writing will follow the PRISMA-ScR guidelines. The search strategy will be carried out in the PubMed, BVS, CENTRAL, Embase, Periódicos CAPES and Google Scholar databases, including publications from the last 10 years without language restrictions. The Covidence platform will be used in the selection, identification of duplicates, two-stage review and data extraction, conducted by independent reviewers. The data will be analyzed according to the question and objectives of the scoping review, and the results will be presented in tables, charts, and a narrative summary. Final considerations It is expected that the proposed scoping review protocol will present the general state of scientific evidence and identify gaps to be clarified on the topic. - “electrocardiogram” - “rheumatic diseases” - “autoimmune diseases” Competing Interest Statement The authors have declared no competing interest. Funding Statement This study did not receive any funding Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data Availability All data produced are available online at OSF: DOI 10.17605/OSF.IO/G6QDT