The bony endometrium: a rare case of osseus metaplasia of endometrium

Saman Syed, Jyotsna Telugu, Shaik Sameera
In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2023 · vol. 12(11) , pp. 3420–3422 · doi:10.18203/2320-1770.ijrcog20233324 · W4387994423
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This case report describes a 22-year-old woman with secondary amenorrhea who was diagnosed with osseous metaplasia of the endometrium after hysteroscopic removal and histopathological examination of bony fragments.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This paper reports a rare case of osseous (bony) metaplasia of the endometrium in a 22-year-old woman presenting with secondary amenorrhea and associated infertility concerns. High-level workup included ultrasonography showing echogenic calcified endometrium, hysteroscopy revealing bony fragments within the uterine cavity that were removed, and histopathology confirming osseous metaplasia; the procedure was uneventful. A major limitation is that the article is a single case report, leaving the proposed pathophysiology incompletely understood. Relevance to endometriosis: the paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via keyword match in the upstream search index.

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Abstract

Osseous metaplasia of endometrium is an uncommon condition which presents as a bone in endometrium. The pathophysiology of this condition is still not understood completely. Many theories have been formulated to explain its occurrence. Most patients with this disorder present with 2o amenorrhoea or 2o infertility. Here, we present a case of 22 years old woman presenting to us with secondary amenorrhoea. Ultrasonography showed echogenic calcified endometrium suggestive of calcification. Hysteroscopy was done which revealed bony fragments in uterine cavity, which were removed, procedure went uneventful and patient was started on oestrogen and progesterone for endometrium regeneration. Histopathology report was suggestive of osseous metaplasia of endometrium.
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The bony endometrium: a rare case of osseus metaplasia of endometrium DOI: https://doi.org/10.18203/2320-1770.ijrcog20233324Keywords: Osseous Metaplasia, Secondary amenorrhoea, Ultrasound, InfertilityAbstract Osseous metaplasia of endometrium is an uncommon condition which presents as a bone in endometrium. The pathophysiology of this condition is still not understood completely. Many theories have been formulated to explain its occurrence. Most patients with this disorder present with 2o amenorrhoea or 2o infertility. Here, we present a case of 22 years old woman presenting to us with secondary amenorrhoea. Ultrasonography showed echogenic calcified endometrium suggestive of calcification. Hysteroscopy was done which revealed bony fragments in uterine cavity, which were removed, procedure went uneventful and patient was started on oestrogen and progesterone for endometrium regeneration. Histopathology report was suggestive of osseous metaplasia of endometrium. Metrics References Umashankar T, Patted S, Handigund R. Endometrial osseous metaplasia: Clinicopathological study of a case and literature review. J Hum Reprod Sci. 2010;3(2):102-4. Adamson NE Jr, Sommers SC. Endometrial ossification; report of two cases. Am J Obstet Gynecol. 1954;67(1):187-90. Bhatia NN, Hoshiko MG. Uterine Osseous Metaplasia. Obstet Gynecol. 1982;60(2):256-9. Silverberg SG, Tabbara SO. The uterine corpus. In: Silverberg SG, editor. Principles and practices of surgical pathology and cytopathology. 3rd edition. USA: Churchill Livingstone. 2015;2470-2. Cayuela E, Perez-Medina T, Vilanova J, Alejo M, Cañadas P. True osseous metaplasia of the endometrium: the bone is not from a fetus. Fertil Steril. 2009;91(4):1293.e1-4. Bahçeci M, Demirel LC. Osseous metaplasia of the endometrium: a rare cause of infertility and its hysteroscopic management. Hum Reprod. 1996;11(11):2537-9. Marcus SF, Bhattacharya J, Williams G, Brinsden P, Hamou J. Endometrial ossification: a cause of secondary infertility. Report of two cases. Am J Obstet Gynecol. 1994;170(5 Pt 1):1381-3. Shimizu M, Nakayama M. Endometrial ossification in a postmenopausal woman. J Clin Pathol. 1997;50(2):171-2. Tulandi T, Al-Sunaidi M, Arseneau J, Tonin PN, Arcand SL. Calcified tissue of fetal origin in utero. Fertil Steril. 2008;89(1):217-8. Madaan M, Suman S, Sharma R, Kapoor N, Garg P, Raj SS. Osseous metaplasia of the endometrium and successful hysteroscopic resection: a report of two cases and a review of the literature. Asian J Endosc Surg. 2015;8(1):63-6. Sugino N, Shimamura K, Takiguchi S, Tamura H, Ono M, Nakata M, et al. Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy. Hum Reprod. 1996;11(5):1073-8.

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