Feasibility Study of Hyperspectral Colposcopy as a Novel Tool for Detecting Precancerous Cervical Lesions

Feasibility Study of Hyperspectral Colposcopy as a Novel Tool for Detecting Precancerous Cervical Lesions | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Feasibility Study of Hyperspectral Colposcopy as a Novel Tool for Detecting Precancerous Cervical Lesions Carlos Vega, Norberto Medina, Laura Quintana-Quintana, Raquel Leon, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4343232/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 04 Jan, 2025 Read the published version in Scientific Reports → Version 1 posted 11 You are reading this latest preprint version Abstract Cervical cancer remains a major global health concern, with a specially alarming incidence in younger women. Traditional detection techniques such as the Pap smear and colposcopy often lack sensitivity and specificity and are highly dependent on the experience of the gynaecologist. In response, this study proposes the use of Hyperspectral Imaging, a pioneering technology that combines traditional imaging with spectroscopy to provide detailed spatial and spectral information. Over a period of six-months, our custom-designed hyperspectral colposcope was used on 62 patients. The gathered data underwent a specialized preprocessing workflow using a PCA-based strategy for unsupervised segmentation of the cervical region. This process extracted spectral signatures from various tissue types, and our subsequent statistical analysis highlighted its ability to detect differences and alterations in the cervical tissue. This offers a promising avenue for improving the precision of cervical lesion diagnosis. Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 04 Jan, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 12 Nov, 2024 Reviews received at journal 09 Nov, 2024 Reviewers agreed at journal 25 Oct, 2024 Reviewers agreed at journal 23 Oct, 2024 Reviews received at journal 16 Sep, 2024 Reviewers agreed at journal 14 Aug, 2024 Reviewers invited by journal 29 Jul, 2024 Editor assigned by journal 25 Jul, 2024 Editor invited by journal 03 May, 2024 Submission checks completed at journal 02 May, 2024 First submitted to journal 29 Apr, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4343232","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":299919259,"identity":"fce28e33-2294-4b5e-951b-fdb03389ab28","order_by":0,"name":"Carlos Vega","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3klEQVRIiWNgGAWjYNCCCgkI/YB4LWegWhKI1sHYxkCCFv4ZyYdf/Jxnkbi2/QCbROKOWnkG9nb87pO4kZZm2btNInHbmQSgljPHDRt4zhjg1WLAc8bMgBek5QBIS9uxBAaJHPwOM+A5/83w7xyglvMPoFrkn+N3mAF7D/Nj3gaglhtgW2qAtjDgd5jE8TYzZpljEsbbbjxstkg8c8CwjScHvxb+ZubHH9/U1MluO5988MbHHXXy/OzH8TsMCNig8cjYAESHGdgIqQcC5g9wJmNDHREaRsEoGAWjYKQBAIcESM9PFv6qAAAAAElFTkSuQmCC","orcid":"","institution":"University of Las Palmas de Gran Canaria","correspondingAuthor":true,"prefix":"","firstName":"Carlos","middleName":"","lastName":"Vega","suffix":""},{"id":299919264,"identity":"1f2b41fb-db6f-47b3-91e0-f8bbd1e3e95f","order_by":1,"name":"Norberto Medina","email":"","orcid":"","institution":"Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI), Servicio Canario de Salud (SCS)","correspondingAuthor":false,"prefix":"","firstName":"Norberto","middleName":"","lastName":"Medina","suffix":""},{"id":299919267,"identity":"00f00d21-d21f-4eda-9020-42d365ea4af9","order_by":2,"name":"Laura Quintana-Quintana","email":"","orcid":"","institution":"University of Las Palmas de Gran Canaria","correspondingAuthor":false,"prefix":"","firstName":"Laura","middleName":"","lastName":"Quintana-Quintana","suffix":""},{"id":299919270,"identity":"f6338d1a-1afa-499e-9c7d-857359a030d3","order_by":3,"name":"Raquel Leon","email":"","orcid":"","institution":"University of Las Palmas de Gran Canaria","correspondingAuthor":false,"prefix":"","firstName":"Raquel","middleName":"","lastName":"Leon","suffix":""},{"id":299919274,"identity":"0969bcb6-93a8-4497-8d34-aaa1b906b0b2","order_by":4,"name":"Himar Fabelo","email":"","orcid":"","institution":"Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC)","correspondingAuthor":false,"prefix":"","firstName":"Himar","middleName":"","lastName":"Fabelo","suffix":""},{"id":299919278,"identity":"80d6e006-89ab-4a17-9939-1b0bc3ebfac9","order_by":5,"name":"Jorge Rial","email":"","orcid":"","institution":"OPTOMIC ESPAÑA S.A","correspondingAuthor":false,"prefix":"","firstName":"Jorge","middleName":"","lastName":"Rial","suffix":""},{"id":299919282,"identity":"9bcff8ba-2105-4b7d-bcd7-015432b88e6f","order_by":6,"name":"Alicia Martín","email":"","orcid":"","institution":"Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI), Servicio Canario de Salud (SCS)","correspondingAuthor":false,"prefix":"","firstName":"Alicia","middleName":"","lastName":"Martín","suffix":""},{"id":299919286,"identity":"8f9f9b00-39e4-43f0-a4c9-79634390d9b9","order_by":7,"name":"Gustavo M. 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