Mean of CA 125 in making therapy decision in adnexal inflammatory tumors

Branka Nikolić, Nikolić B, Ana Mitrović, Mitrović A, Jelena Lazić, Lazić J
Bosnian journal of basic medical sciences · 2006 · vol. 6(2) , pp. 3–6 · doi:10.17305/bjbms.2006.3160 · PMID:16879104 · PMC7192643 · W2400714802
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In 57 patients with adnexal inflammatory tumors, elevated CA-125 levels predicted the need for operative treatment over antibiotic therapy, particularly given potential associations with endometriosis and malignancy.

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This study evaluated the utility of serum CA 125 levels in guiding therapeutic decisions for patients with adnexal inflammatory tumors. Among 57 confirmed cases, CA 125 was elevated in 27 patients, and those undergoing surgery showed a significant decrease in levels within five days post-operation, whereas only eight patients without elevation were successfully managed with antibiotics alone. The authors note that while routine testing is unnecessary, CA 125 may help clarify unclear clinical or Doppler findings to determine the need for operative intervention. This paper is centrally about endometriosis — specifically noting that inflammatory tumors can develop within endometriotic masses and that endometriosis carries a risk of malignancy, which complicates the interpretation of CA 125 levels in these cases.

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Abstract

UNLABELLED: LABORATORY FINDINGS such are white blood count and sedimentation rate are of relative value in inflammations of the upper genital tract and adnexal inflammatory tumors. Antibiotics are administrated in all cases according to the protocol but some of them need operative treatment also. Inflammatory tumors can develop in endometriotic and even in cancer adnexal masses. CA 125 is elevated in great number of patients with advanced ovarian cancer. It can also be elevated in endometriosis, inflammations and in non-gynecological malignancies. Adnexal inflammatory tumor was confirmed in 57 patients. LABORATORY FINDINGS: white blood count and sedimentation rate were in normal levels in 17 patients. CA 125 was elevated in 27 patients. 49 patients were operated and CA 125 decreased in the first 5 days after the operation. Only 8 patients without CA 125 elevation were successfully treated by mean of antibiotics. Even there is no need for routine examining of serum CA 125 in adnexal inflammatory tumors it can be examined in cases with suspected Doppler ultrasonographic findings or unclear clinical findings. Endometriosis brings some risk of malignancy. Inflammatory tumor can develop in endometriotic tumor as well as in necrotic malignant ovary tissue. These could be reasons for making decision to do the operation in cases with inflammatory tumor followed with increased CA 125, hystological assessment and serious interpretation of final results.
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Mean of CA 125 in making therapy decision in adnexal inflammatory tumors DOI: https://doi.org/10.17305/bjbms.2006.3160Keywords: Adnexal inflammatory tumor, CA 125, Resistance Index, Transvaginal Doppler ultrasonography, endometriosisAbstract Laboratory findings such are white blood count and sedimentation rate are of relative value in inflammations of the upper genital tract and adnexal inflammatory tumors. Antibiotics are administrated in all cases according to the protocol but some of them need operative treatment also. Inflammatory tumors can develop in endometriotic and even in cancer adnexal masses. CA 125 is elevated in great number of patients with advanced ovarian cancer. It can also be elevated in endometriosis, inflammations and in non-gynecological malignancies. Adnexal inflammatory tumor was confirmed in 57 patients. Laboratory findings: white blood count and sedimentation rate were in normal levels in 17 patients. CA 125 was elevated in 27 patients. 49 patients were operated and CA 125 decreased in the first 5 days after the operation. Only 8 patients without CA 125 elevation were successfully treated by mean of antibiotics. Even there is no need for routine examining of serum CA 125 in adnexal inflammatory tumors it can be examined in cases with suspected Doppler ultrasonographic findings or unclear clinical findings. Endometriosis brings some risk of malignancy. Inflammatory tumor can develop in endometriotic tumor as well as in necrotic malignant ovary tissue. These could be reasons for making decision to do the operation in cases with inflammatory tumor followed with increased CA 125, hystological assessment and serious interpretation of final results. Citations Downloads Downloads Published How to Cite Accepted 2018-02-08 Published 2006-05-20

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Condition tags

endometriosis

MeSH descriptors

Adnexal Diseases Biomarkers, Tumor CA-125 Antigen Genital Neoplasms, Female Inflammation Adnexal Diseases Adnexal Diseases Adnexal Diseases Adult Anti-Bacterial Agents Anti-Bacterial Agents Biomarkers, Tumor CA-125 Antigen Endometriosis Endometriosis Female Genital Neoplasms, Female Genital Neoplasms, Female Genital Neoplasms, Female Humans

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