CYP17 polymorphism and hot flushes in postmenopausal women

A.M. Massad-Costa, Naiara Correa Nogueira-de-Souza, Cristina Valletta de Carvalho, I. D. da Silva, Camila Guindalini, Roberto César Nogueira, José Maria Soares, Mauro Abi Haidar, Edmund Chada Baracat
In: Climacteric · 2008 · vol. 11(5) , pp. 404–408 · doi:10.1080/13697130802395026 · PMID:18781485 · W2120213374
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Abstract

OBJECTIVE: To investigate the association between the CYP17alpha gene polymorphism and hot flushes in postmenopausal women. METHODS: Ninety-three non-hysterectomized, postmenopausal women were enrolled in this study. Vasomotor symptoms were assessed at the baseline visit and based on information provided by each participant. The genotypic polymorphism of CYP17alpha gene was analyzed by PCR-RFLP assay using genomic DNA isolated from peripheral blood lymphocytes. RESULTS: Thirty-six women reported hot flushes of mild intensity, 25 reported hot flushes of moderate intensity and 32 of severe intensity. There was no significant difference between the severity of hot flushes and the CYP17 genotype or allele frequencies, 0.58 and 0.67 respectively. No association was found between hot flush severity and the CYP17 allele (odds ratio = 1.17, p = 0.61). CONCLUSION: The results of this study suggest that the CYP17 MspAI polymorphism was not significantly associated with an increased risk of reporting hot flushes.

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