as markers of active angiogenesis in endometriosis

The aim of the present study was to evaluate the expression of the neo-an-giogenic marker endoglin and its localization in tissues of normal and endo-metriotic patients as well as to compare it with one new angiogenic marker candidate – S100A13. Human recombinant S100A13 and endoglin 35mer synthetic peptide of the intracellular domain were used for the production of rabbit polyclonal antisera. The antisera were characterized for specificity, using immunoenzyme assay (ELISA), Western blot and immunohistochem-istry. Formalin-fixed, paraffin-embedded tissue sections from normal endo-metrium, adenomyosis, ovarian endometriosis, eutopic endometrium from different endometriotic specimens were tested by immunohistochemistry. No endoglin specific staining was observed on the microvessels of the normal endometrium. In adenomyosis and ovarian endometriosis, the expression pattern was different – endoglin was expressed in all microvessels, with an