Area under curve of temporal estradiol measurements for prediction of the detrimental effect of estrogen exposure on implantation

Tayfun Kutlu; Enis Özkaya; Habibe Ayvacı; Belgin Devranoğlu; İlhan Şanverdi; Yavuz Şahin; Taylan Şenol; Ateş Karateke

doi:10.1016/j.ijgo.2016.04.015

Area under curve of temporal estradiol measurements for prediction of the detrimental effect of estrogen exposure on implantation

Tayfun Kutlu, Enis Özkaya, Habibe Ayvacı, Belgin Devranoğlu, İlhan Şanverdi, Yavuz Şahin, Taylan Şenol, Ateş Karateke

In: International Journal of Gynecology & Obstetrics · 2016 · vol. 135(2) , pp. 168–171 · doi:10.1016/j.ijgo.2016.04.015 · PMID:27484925 · W2488543248

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The area under the curve of temporal estradiol measurements during assisted reproductive technology cycles was found to predict implantation failure and clinical pregnancy success.

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Abstract

OBJECTIVE: To assess whether the area under the curve of temporal estradiol measurements (AUCEM) during cycles of assisted reproductive technology (ART) can be used to predict failure of implantation and clinical pregnancy. METHODS: In a prospective study, women aged 24-39years undergoing ART at a center in Turkey were enrolled between January and December 2014. Eligible patients had a regular menstrual cycle, normal levels of serum prolactin, and no hormone treatment within the past 3months. The area under the curve of the time course of estradiol measurements was calculated for each participant, and assessed for its ability to predict successful implantation. RESULTS: Among 282 participants, 109 (38.6%) women had successful implantation. There was a significant difference between the two groups of women in AUCEM, estradiol per day (AUCEM divided by duration of stimulation), and endometrial thickness on the day of human chorionic gonadotropin administration (P<0.05 for all). CONCLUSION: The area under the curve of estradiol measurements during ART cycles might be useful for predicting failure of implantation and clinical pregnancy.

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A meta-analysis of the relationship between endometrial thickness and outcome of in vitro fertilization cycles 2011

References (28)

A meta-analysis of the relationship between endometrial thickness and outcome of in vitro fertilization cycles via openalex
doi:10.1016/j.fertnstert.2015.01.045 via openalex
doi:10.1038/nrg1808 via openalex
doi:10.1016/s0015-0282(01)02018-0 via openalex
doi:10.22074/ijfs.2021.244054 via openalex
doi:10.1371/journal.pone.0048933 via openalex
doi:10.1093/humrep/der452 via openalex
doi:10.1095/biolreprod67.4.1268 via openalex
doi:10.1016/s0015-0282(16)58337-x via openalex
doi:10.5653/cerm.2011.38.3.119 via openalex
doi:10.1098/rsob.130035 via openalex
doi:10.1530/jme-15-0254 via openalex
doi:10.1073/pnas.0530162100 via openalex
W2162416216 via openalex
W2416196378 via openalex
W4327627993 via openalex
W6622670422 via openalex
W6684162363 via openalex
W6716713832 via openalex
doi:10.1111/aji.12226 via openalex
doi:10.1016/s1043-2760(03)00084-5 via openalex
doi:10.1095/biolreprod.103.025692 via openalex
doi:10.4103/0974-1208.165153 via openalex
doi:10.1016/s0306-4530(02)00108-7 via openalex
doi:10.1093/humrep/15.2.250 via openalex
doi:10.1016/s0015-0282(98)00140-x via openalex
doi:10.1016/s0039-128x(03)00126-0 via openalex
doi:10.1093/oxfordjournals.humrep.a136313 via openalex

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[1] A meta-analysis of the relationship between endometrial thickness and outcome of in vitro fertilization cycles 2011