[The expressions and the roles of SDF-1/CXCR-4 and SDF-1/CXCR-4 in human endometriosis].

Z Ouyang, Zhuo Ouyang, Sun Jp, J P Sun, Tian Xl, X L Tian, M X Chen, MX Chen, Zhai Jj, J J Zhai
Zhonghua yi xue za zhi · 2018 · vol. 98(23) , pp. 1854–1858 · doi:10.3760/cma.j.issn.0376-2491.2018.23.010 · PMID:29925169 · W2977521831
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

High expression of SDF-1 and CXCR-4 in endometriosis promotes endometrial stromal cell mitosis and proliferation, indicating their significant roles in the disease's pathogenesis.

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Abstract

The high expressions of SDF-1 and CXCR-4 in endometriosis as well as SDF-1 through its specific receptor CXCR-4 promoted the mitosis and proliferation of endometrial stromal cells, suggesting that SDF-1 and CXCR-4 played important roles in the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Chemokine CXCL12 Endometrium Female Humans Receptors, CXCR4 RNA, Messenger Signal Transduction Stromal Cells

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europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
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License: CC0 · commercial use OK