Endometriosis-Associated Rectal Malignancies Combined With Endometrial Cancer: A Case Report

Yanfang Bai, Dongfeng Zhai, Shannon M. Fan, Sige Fan, Changqian Chen, Huihui Chen, Wei Huang
In: Clinical and Experimental Obstetrics & Gynecology · 2025 · vol. 52(7) · doi:10.31083/ceog39232 · W4413026847
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Abstract

Background: The incidence of endometriosis-associated malignancies (EAMs) is approximately 1%, with the majority occurring in the ovaries. This condition is often referred to as endometriosis-associated ovarian cancer (EAOC). However, the EAMs are rarer occurrences at other sites, such as the rectovaginal septum, abdominal wall, or perineal incision. Case: This case involves a 51-year-old female hospitalized at Zhuhai Integrated Traditional Chinese and Western Medicine Hospital with abdominal pain and constipation. Colonoscopy revealed a rectal mass, and histopathological analysis indicated adenocarcinoma, suggesting endometrial cancer metastasis. However, following total laparoscopic hysterectomy, rectal resection, and lymph node dissection, pathological examination confirmed a final diagnosis of rectal endometriosis-associated malignancy (EAM) combined with endometrial cancer. Following surgery, chemotherapy, and radiotherapy, the patient remained disease-free during a 2-year follow-up period. Conclusions: This case is rare and noteworthy, involving EAMs of the rectum combined with EC. Surgical intervention followed by adjuvant treatment could improve survival outcomes. Therefore, an accurate diagnosis is critical for effective management.

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last seen: 2026-06-10T17:14:06.276822+00:00
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